2021
DOI: 10.1016/j.biomaterials.2021.120762
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4D spatiotemporal modulation of biomolecules distribution in anisotropic corrugated microwrinkles via electrically manipulated microcapsules within hierarchical hydrogel for spinal cord regeneration

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Cited by 18 publications
(18 citation statements)
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“…Moreover, regenerated axons aligned along the axis of host axons, mimicking well the native structures in the spinal cord. As well as 3D hydrogel, 4D dynamic hydrogel can be generated using hybrid GelMA-microcapsule hydrogel (HGMH) with sinuate microwrinkles according to asymmetric water swelling ( Chiang et al, 2021 ). Poly- (lactic-co-glycolic acid) (PLGA) microcapsules, which were aligned on HGMH, loaded with NT-3 arrayed into triangle pattern by dielectrophoresis and produced a gradient of NT-3 to modulate cell differentiation and growth.…”
Section: Applications Of Nsc Transplantation Therapy To Treat Scimentioning
confidence: 99%
“…Moreover, regenerated axons aligned along the axis of host axons, mimicking well the native structures in the spinal cord. As well as 3D hydrogel, 4D dynamic hydrogel can be generated using hybrid GelMA-microcapsule hydrogel (HGMH) with sinuate microwrinkles according to asymmetric water swelling ( Chiang et al, 2021 ). Poly- (lactic-co-glycolic acid) (PLGA) microcapsules, which were aligned on HGMH, loaded with NT-3 arrayed into triangle pattern by dielectrophoresis and produced a gradient of NT-3 to modulate cell differentiation and growth.…”
Section: Applications Of Nsc Transplantation Therapy To Treat Scimentioning
confidence: 99%
“…First, neurons can be directly mixed with different types of cells and grown in Petri dishes in a predefined proportion to establish a 2D co-culture system of primary neuron. Since it takes a certain amount of time for neurons to adhere and develop neurites, neurons could be seeded in the Petri dish before other cells while other types of cells could be seeded at a desired time point (Natunen et al, 2019;Wang Y. S. et al, 2021). Similarly, the sandwich culture is another method to establish a 2D co-culture system of primary neurons and also creates a microenvironment of neuro-glial interactions.…”
Section: Modalitiesmentioning
confidence: 99%
“…2D Co-culture system of primary neuron A 2D co-culture system of primary neurons established by directly mixing different types of cells or sandwich culture is suitable for exploring the interaction between neurons and glial cells, immune cells, and other different types of cells (Mai et al, 2020). For example, a 2D co-culture system of primary neuron and glial cells were applied in the study of neuro-glial synaptic connection (Wang Y. S. et al, 2021). A major application of 2D co-culture system of primary neurons is to study the effects of other types of cells on primary neurons under specific pathological conditions and to develop potential therapies.…”
Section: Modalitiesmentioning
confidence: 99%
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“…However, the effective repair of long-distance peripheral injuries using artificial nerve grafts remains a great challenge (69)(70)(71)(72). For CNS injury, the current strategies are even limited to achieving desirable nerve repair and functional recovery (73)(74)(75). In addition to therapies that directly promote rapid axon growth, recent studies have focused on creating a favorable microenvironment at injury sites by regulating the immune response (76)(77)(78).…”
Section: T Cell-mediated Therapies For Nerve Injuriesmentioning
confidence: 99%