5-Aminolevulinic acid-mediated photodynamic therapy for oral cancers and precancers

Chen, Hsin‐Ming; Yu, Chuan‐Hang; Lin, Hung-Pin; Cheng, Shih‐Jung; Chiang, Chun-Pin

doi:10.1016/j.jds.2012.03.023

Cited by 38 publications

(18 citation statements)

References 54 publications

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“…For three common oral precancerous lesions, topical ALA is more effective for oral erythroleukoplakia (OEL) and oral verrucous hyperplasia (OVH) lesions but less effective for oral leukoplakia (OL). The different outcomes are due to the thinner keratin layer in OEL and OVH compared with OL (Chen, Yu, Lin, Cheng, & Chiang, ; Zhang et al, ).…”

Section: Discussionmentioning

confidence: 99%

MAL‐PDT inhibits oral precancerous cells and lesions via autophagic cell death

Chen

et al. 2019

Oral Diseases

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Background: Oral cancer is a common cancer with a high mortality rate. While surgery is the most effective treatment for oral cancer, it frequently causes deformity and dysfunction in the orofacial region. In this study, methyl aminolevulinate photodynamic therapy (MAL-PDT) as a prevention tool against progression of precancerous lesion to oral cancer was explored. Methods:For in vitro studies, we evaluated the effects of MAL-PDT on viability of DOK oral precancerous cells by XTT, cell morphology by TEM, and intracellular signaling pathways by flow cytometry, Western blotting, and immunofluorescence. For in vivo study, DMBA was used to induce oral precancerous lesions in hamsters followed by MAL-PDT treatment. We measured tumor size and body weight weekly. After sacrifice, buccal pouch lesions were processed for H&E stain and immunohistochemistry analysis. Results: MAL-PDT induced autophagic cell death in DOK oral precancerous cells. The autophagy-related markers LC3II and p62/SQSTM1 and autophagosome formation in DOK cells were increased after MAL-PDT treatment. In vivo, Metvix ® -PDT treatment decreased tumor growth and enhanced LC3II expression in hamster buccal pouch tumors induced by DMBA.

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Section: Discussionmentioning

confidence: 99%

MAL‐PDT inhibits oral precancerous cells and lesions via autophagic cell death

Chen

et al. 2019

Oral Diseases

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“…Although oral leukoplakia lesions can be eradicated by surgical excision, laser surgery (2), and photodynamic therapy (3), cryotherapy is also an effective and alternative treatment modality for oral leukoplakia lesions (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Cryotherapy is a method which locally destroys lesional tissues by freezing in situ (17).…”

Section: Introductionmentioning

confidence: 99%

Cryogun cryotherapy for oral leukoplakia and adjacent melanosis lesions

Chen

Cheng

Lin

et al. 2014

J Oral Pathology Medicine

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“…Similarly, ALA-PDT was developed in the 1990s for the treatment of nonmalignant skin disorders and has gradually been applied to the treatment of CA in recent years [3,10]. 5-ALA is a precursor of protoporphyrin IX and is an efficient photosensitizer [11]. HPV infection causes cells to rapidly proliferate and to preferentially accumulate protoporphyrin IX compared with the surrounding noninfected cells.…”

Section: Introductionmentioning

confidence: 99%

Clinical Analysis of Five Methods Used to Treat Condylomata Acuminata

Shi

Zhang²,

Ma³

et al. 2013

Dermatology

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Objective: Treatments for condylomata acuminata (CA) include pharmacotherapy and surgical therapies, but each treatment has its limitations. The aim of this study was to investigate the virus clearance rate, wart cure rate and safety of 5 methods on CA. Methods: 361 patients diagnosed with CA were divided into groups A (<0.5 cm), B (0.5-2.0 cm) and C (>2.0-4.0 cm) according to the maximum diameter of their lesion. Five treatments were compared in each group, and the clinical outcomes were evaluated during follow-ups. Results: A 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is preferred if the maximum lesion diameter is <0.5 cm and an ALA-PDT plus cryotherapy treatment is preferred for lesions 0.5-2.0 cm. For lesions >2.0- 4.0 cm, an ALA-PDT retreatment (after cryotherapy or CO₂ laser treatment) should be the first choice. Conclusions: The treatments for CA should be chosen according to the maximum diameter of each patient's lesion.

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5-Aminolevulinic acid-mediated photodynamic therapy for oral cancers and precancers

Cited by 38 publications

References 54 publications

MAL‐PDT inhibits oral precancerous cells and lesions via autophagic cell death

MAL‐PDT inhibits oral precancerous cells and lesions via autophagic cell death

Cryogun cryotherapy for oral leukoplakia and adjacent melanosis lesions

Clinical Analysis of Five Methods Used to Treat Condylomata Acuminata

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