5-(Pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Abstract

In the title compound, C11H9N5O, the pyrazolo­pyrimidin-4-one ring system is almost planar, with a maximum deviation of 0.0546 (13) Å for the O atom. The crystal packing is stabilized by inter­molecular N—H⋯N, C—H⋯O and C—H⋯N hydrogen bonds. In addition, π–π stacking is found between the pyridine ring and the pyrazolo­pyrimidin-4-one ring systems, with centroid–centroid distances in the range 3.9627 (12)–4.6781 (12) Å.

Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives

“…In continuation of our work on the synthesis of the excess of allopurinol [16][17][18][19][20][21][22][23], we have envisioned the synthesis new pyrazolo [3,4-b]pyridine derivatives by thionation, alkylation and 1,3-dipolar cycloaddition reactions in order to evaluate their inhibitory effect of α-amylase and α-glucosidase. The melting points were taken on an electrothermal capillary melting point apparatus.…”

Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives

“…In continuation of our work on the synthesis of the excess of allopurinol [23][24][25][26][27][28], compounds 2 and 2a-b have been synthesized by using reported methods [29][30][31]. Herein we report simple efficient synthesis of spiro thiadiazoline-(pyrazolo [3,4-…”