5 The Pharmacology of Vitamin E

Mj, Kelly

doi:10.1016/s0079-6468(08)70280-7

Cited by 11 publications

(6 citation statements)

References 183 publications

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“…Vitamin E is located at various sites in cell membranes, and in close proximity to membranebound enzymes that can generate free radicals (Kelly, 1988). This substance acts as a free-radical scavenger, helping to protect the cell against lipid peroxidation (Yanardag et al, 2001;Packer, 1991;McCay, 1985;Ura et al, 1987).…”

Section: Vitamin Ementioning

confidence: 99%

Prophylactic effects of magnesium and vitamin E in rat spinal cord radiation damage: evaluation based on lipid peroxidation levels

et al. 2004

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Section: Vitamin Ementioning

confidence: 99%

Prophylactic effects of magnesium and vitamin E in rat spinal cord radiation damage: evaluation based on lipid peroxidation levels

et al. 2004

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“…Reports of a degree of structural specificity suggest the possibility of a mechanism other than that involving the known anti-oxidant capacity of the vitamin. A study of the mechanism of protection produced by vitamin E in guineapig isolated portal vein using four spasmogenic agents, methoxamine, acetylcholine, histamine and potassium, each with a different mechanism of action, produced responses which were reduced by hypoxia but were then not protected by the presence of vitamin E (Kelly 1988) as noradrenalineinduced responses are in this study. This lack of general effectiveness of the vitamin in protecting hypoxic vascular tissue argues against an antioxidant mechanism.…”

Section: Discussionmentioning

confidence: 68%

Characteristics of the Protective Action of α‐Tocopherol in Vascular Hypoxia

Richardson

1996

Pharmacology & Toxicology

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The functioning of the guinea-pig isolated portal vein was monitored by measuring spontaneous mechanical activity, responses to electrical stimulation and administered noradrenaline in normoxic conditions. The effect of hypoxia, induced by bubbling the physiological bathing solution with a 95% N(2)/5% CO(2) gas mixture, on the mechanical performance of the vein was then assessed. Spontaneous activity declined in hypoxia, with mean contraction tension reduced by 55 + or - 8.8%. The responses to electrical field stimulation (2-32 Hz, 0.7 msec. 70 V) were lowered by 14 + or - 4.6% but contractions produced by a range of noradrenaline concentrations (0.01-160 mu M) were unaffected by hypoxia. Substitution of glucose in the bathing solution with sucrose, a substrate unavailable to the cells for energy generation, produced a marked enhancement of the effect of hypoxia. Spontaneous activity was reduced by 76 + or - 8.3%, electrically-induced activity by 80 + or - 14.4% and noradrenaline-induced responses by 85 + or - 6.8%. Although in normoxia the activity and responses of the portal vein were unaffected by the presence of alpha-tocopherol, it significantly protected the functioning of the vein in hypoxic conditions. This effect was concentration-dependent within the range 10-160 mu M and was most marked when glucose was replaced by sucrose in the bathing solution.

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“…The relative safety of nutritional antioxidants has led to increasing research into their use for a variety of age-related and degenerative diseases in which oxidative stress has been implicated. Pharmacological [57] and supplemental use of antioxi dant micronutrients, e.g. vitamin E and selenium, may be of some value in the treatment of geriatric subjects [58].…”

Section: Discussionmentioning

confidence: 99%

Aluminosilicate-lnduced Free Radical Generation by Murine Brain Glial Cells in vitro: Potential Significance in the Aetiopathogenesis of Alzheimer's Dementia

Evans

Peterhans

Bürge

et al. 1992

Dement Geriatr Cogn Disord

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While previous studies have identified aluminosilicate deposits within the senile plaque cores from subjects with Alzheimer''s dementia, their possible role in the aetiopathogenesis of the disease remains unknown. In the present in vitro chemiluminescent study, we show that cultured murine glial cells exhibit the capacity to generate free radical and related oxygen-derived metabolites when exposed to various natural and synthetic model aluminosilicate particulate samples of differing particle size, morphology and composition. These results, if applicable to the proposed analogous in vivo situation in humans, suggest that further research into the biochemical and cellular mechanisms influencing the production and modulation of tissue-injurious free radical oxygen-derived metabolites within the brain, could have significant implications in the pathogenesis, prevention and treatment of Alzheimer''s disease.

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5 The Pharmacology of Vitamin E

Cited by 11 publications

References 183 publications

Prophylactic effects of magnesium and vitamin E in rat spinal cord radiation damage: evaluation based on lipid peroxidation levels

Prophylactic effects of magnesium and vitamin E in rat spinal cord radiation damage: evaluation based on lipid peroxidation levels

Characteristics of the Protective Action of α‐Tocopherol in Vascular Hypoxia

Aluminosilicate-lnduced Free Radical Generation by Murine Brain Glial Cells in vitro: Potential Significance in the Aetiopathogenesis of Alzheimer's Dementia

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