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Hashimoto, Yoshiya; Moriguchi, Y; Oda, Hiroshi; Nishikawa, J; Nishihara, Tsutomu; Nakamura, Masaaki

doi:10.1023/a:1013009006522

Cited by 20 publications

(2 citation statements)

References 18 publications

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“…36 In another study, BPA, but neither bis-GMA nor TEGDMA, showed estrogenic activity. 57 Other studies have revealed that only BPA and bis-DMA, but not bis-GMA, interacted with the estrogen receptor. 25 More recently, BPA and bis-DMA were shown to be estrogen agonists, androgen antagonists, and inhibitors of aromatase activity at the receptor level.…”

Section: Estrogenic Activity Of Bpa and Bpa Derivativesmentioning

confidence: 96%

Bisphenol A and Related Compounds in Dental Materials

et al. 2010

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CONTEXT Dental sealants and composite filling materials containing bisphenol A (BPA) derivatives are increasingly used in childhood dentistry. Evidence is accumulating that BPA and some BPA derivatives can pose health risks attributable to their endocrine-disrupting, estrogenic properties. OBJECTIVES To systematically compile and critically evaluate the literature characterizing BPA content of dental materials; to assess BPA exposures from dental materials and potential health risks; and to develop evidence-based guidance for reducing BPA exposures while promoting oral health. METHODS The extant toxicological literature and material safety data sheets were used as data sources. RESULTS BPA is released from dental resins through salivary enzymatic hydrolysis of BPA derivatives, and BPA is detectable in saliva for up to 3 hours after resin placement. The quantity and duration of systemic BPA absorption is not clear from the available data. Dental products containing the bisphenol A derivative glycidyl dimethacrylate (bis-GMA) are less likely to be hydrolyzed to BPA and have less estrogenicity than those containing bisphenol A dimethacrylate (bis-DMA). Most other BPA derivatives used in dental materials have not been evaluated for estrogenicity. BPA exposure can be reduced by cleaning and rinsing surfaces of sealants and composites immediately after placement. CONCLUSIONS On the basis of the proven benefits of resin-based dental materials and the brevity of BPA exposure, we recommend continued use with strict adherence to precautionary application techniques. Use of these materials should be minimized during pregnancy whenever possible. Manufacturers should be required to report complete information on the chemical composition of dental products and encouraged to develop materials with less estrogenic potential.

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Section: Estrogenic Activity Of Bpa and Bpa Derivativesmentioning

confidence: 96%

Bisphenol A and Related Compounds in Dental Materials

et al. 2010

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“…Although the estrogenicity of BPA has been demonstrated in vitro and in vivo, only a few studies have examined the estrogenicity of BPA derivatives. These studies have primarily been performed in vitro and have found bis-DMA but not bis-GMA (the more common ingredient of most dental resins) to be estrogenic (26, 27). …”

Section: Discussionmentioning

confidence: 99%

Salivary Bisphenol-A Levels due to Dental Sealant/Resin: A Case-Control Study in Korean Children

et al. 2012

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Dental sealants and composite filling materials containing bisphenol-A (BPA) derivatives are increasingly used in children. The aim of this study was to evaluate the association between salivary BPA and the number of tooth surfaces filled with dental sealant, and to determine a cutoff BPA level. Salivary BPA concentration and the number of tooth surfaces filled with dental sealant/resin were determined in 124 age and gender matched children: 62 controls had no dental sealant/resin on their tooth surfaces and 62 cases had more than 4 tooth surfaces with dental sealant/resin. Analysis of covariance (ANCOVA) and conditional logistic regression were performed after controlling for age, gender, salivary flow rate, salivary buffer capacity, frequency of snacking, and frequency of tooth brushing. Salivary BPA levels were 0.002 to 8.305 µg/L. The BPA level of control (0.40 µg/L) was significantly lower than that of case (0.92 µg/L) after controlling for confounders (P = 0.026). Although the 90th BPA percentile had an adjusted OR of 4.58 (95% CI 1.04-20.26, P = 0.045), the significance disappeared in the conditional logistic model. There may be a relationship between salivary BPA level and dental sealant/resin.

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Establishment of a transgenic yeast screening system for estrogenicity and identification of the anti‐estrogenic activity of malachite green

Jiao

Yeung

Chan

et al. 2008

J of Cellular Biochemistry

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Endocrine disruptors refer to chemical compounds in the environment which interfere with the endocrine systems of organisms. Among them, environmental estrogens pose serious problems to aquatic organisms, in particular fish. It is therefore important and necessary to have a fast and low-cost system to screen the large number of different chemical compounds in the aquatic environment for their potential endocrine disrupting actions. In this study, a screening platform was developed to detect xenoestrogens in the aquatic environment using the fission yeast Schizosaccharomyces pombe, and applied for compound screening. The aim was to demonstrate any significant potential differences between the fish screening system and the human screening system. To this end, a yeast expression vector harboring a fish estrogen receptor alpha and a reporter vector containing the estrogen responsive element fused with the Escherichia coli LacZ gene were constructed. After transformation with these two vectors, the transformed yeast clones were confirmed by Western blotting and selected on the basis of the beta-galactosidase activity. In this transgenic yeast system, the natural estrogen (estradiol) and other known xenoestrogens such as diethylstilbestrol, bisphenol A, genistein and dichloro-diphenyl-trichloroethane exhibited dose-dependent activities. Using this system, more than 40 putative endocrine disruptors including phytoestrogens, pesticides, herbicides, industrial dyes and other industrial chemicals were screened. Ten of them were demonstrated to exhibit estrogenic actions. Industrial dyes such as malachite green (MG) that disrupt thyroid hormone synthesis are extensively used and are widely distributed in the aquatic environment. Using this system, MG did not show any estrogenic action, but was demonstrated to exhibit anti-estrogenic activity.

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Untitled

Cited by 20 publications

References 18 publications

Bisphenol A and Related Compounds in Dental Materials

Bisphenol A and Related Compounds in Dental Materials

Salivary Bisphenol-A Levels due to Dental Sealant/Resin: A Case-Control Study in Korean Children

Establishment of a transgenic yeast screening system for estrogenicity and identification of the anti‐estrogenic activity of malachite green

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