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Prayitno, Adi

doi:10.1186/1477-3163-5-13

Cited by 30 publications

(24 citation statements)

References 7 publications

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“…Of interest, EBV was detected also in CC specimens from Indonesian patients, and 68% of analysed cases are co-infected with HPV and EBV [16]. In our study, HPV and EBV co-infection seems to be less frequent in NPC.…”

Section: Discussionsupporting

confidence: 46%

“…Similarly, HPV has been found to interact with p53, suggesting that this interaction promotes cell growth and thereby enhance viral replication [27]. Targeting p53 may be a common requirement for the replication of many types of DNA viruses [16]. In addition, B cells transfected with EBV latent membrane protein lost the regulatory effects of the retinoblastoma (RB) protein, and the HPV E7 transcript has been shown to immunoprecipitate the RB protein [28].…”

Section: Discussionmentioning

confidence: 99%

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Human papillomavirus detection in moroccan patients with nasopharyngeal carcinoma

Laantri

Attaleb

Kandil

et al. 2011

Infect Agents Cancer

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BackgroundNasopharyngeal carcinoma (NPC) is a malignant tumor which arises in surface epithelium of the posterior wall of the nasopharynx. There's is evidence that Epstein Barr virus (EBV) is associated to NPC development. However, many epidemiologic studies point to a connection between viral infections by the human papillomavirus (HPV) and NPC.MethodSeventy Moroccan patients with NPC were screened for EBV and HPV. EBV detection was performed by PCR amplification of BZLF1 gene, encoding the ZEBRA (Z Epstein-Barr Virus Replication Activator) protein, and HPV infection was screened by PCR amplification with subsequent typing by hybridization with specific oligonucleotides for HPV types 16, 18, 31, 33, 35, 45 and 59.ResultsThe age distribution of our patients revealed a bimodal pattern. Sixty two cases (88.9%) were classified as type 3 (undifferentiated carcinoma), 6 (8.6%) as type 2 (non keratinizing NPC) and only 2 (2.9%) cases were classified as type 1 (keratinizing NPC). EBV was detected in all NPC tumors, whereas HPV DNA was revealed in 34% of cases (24/70). Molecular analysis showed that 20.8% (5/24) were infected with HPV31, and the remaining were infected with other oncogenic types (i.e., HPV59, 16, 18, 33, 35 and 45). In addition, statistical analysis showed that there's no association between sex or age and HPV infection (P > 0.1).ConclusionOur data indicated that EBV is commonly associated with NPC in Moroccan patients and show for the first time that NPC tumours from Moroccan patients harbour high risk HPV genotypes.

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Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Human papillomavirus detection in moroccan patients with nasopharyngeal carcinoma

Laantri

Attaleb

Kandil

et al. 2011

Infect Agents Cancer

View full text Add to dashboard Cite

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“…The association of HMSN1 with MS has been reported [45,46,47] and it is possible that the trinucleotide expansion increases susceptibility to epithelial tumours or to EBV. Some suggest a link between cervical cancer and EBV infection [48,49] although this is not fully accepted [50]. …”

Section: Discussionmentioning

confidence: 99%

Multiple Sclerosis, Lymphoma and Nasopharyngeal Carcinoma: The Central Role of Epstein-Barr Virus?

Rolls

Giovannoni²,

Constantinescu³

et al. 2009

Eur Neurol

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Background: Multiple sclerosis (MS) and Hodgkin lymphoma (HL) share epidemiologic characteristics suggesting a possible common etiology. Epstein-Barr virus (EBV) is associated with HL, Burkitt lymphoma, some varieties of non-Hodgkin lymphoma (NHL) and nasopharyngeal carcinoma (NPC).Method:Patients were located through MS databases for (a) Barking and Havering, NE London; catchment ∼400,000; MS patient number 751, and (b) Nottingham, catchment ∼2,000,000; MS patient number 1,236. Search was undertaken for lymphoma or NPC and diagnosis of MS verified by McDonald criteria. Results: We identified five UK-born and resident patients of interest: (1) male with onset HL aged 20 years developing relapsing-remitting MS 11 years later; (2) female with severe relapsing-remitting MS whose partner developed NHL, 5 years after MS diagnosis; (3) female with secondary progressive MS beginning at age 38 years who developed NHL 25 years later; (4) female diagnosed with MS aged 19 years who developed HL 4 years later, and (5) female with hereditary motor and sensory neuropathy developing cervical cancer at the age of 32 years, NPC at 33 years, and RR MS at 36 years. Conclusion: Our study supports a possible association between MS, HL, NHL, and perhaps NPC all of which are associated with EBV infection.

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“…The pathogenesis of cervical cancer is pointed to Human Papilloma Virus (HPV) [3]. HPV infection is associated with malignancies of urogenital tract and anus.…”

Section: Introduction a Cervix Cancermentioning

confidence: 99%

Pattern recognition on 2D cervical cytological digital images for early detection of cervix cancer

Ane

Pandjaitan

Steinberg³

2009

2009 World Congress on Nature &Amp; Biologically Inspired Computing (NaBIC)

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To date, cancer of the uterine cervix is still a leading cause of cancer-related deaths in women in the world. Papanicolau smear test is a well-known screening method of detecting abnormalities in the uterine cervix cells. In Indonesia, Pap smear test is mostly still done conventionally. Due to the small number of skilled and experienced cytologists, the screening procedure becomes time consuming and highly prone to human errors. Coping with these issues, an automated recognition system is developed to enable automatic identification of anomaly in the cervix cells. Recognition of patterns inside a cervix cell is based on the cell morphological features, in terms of size, shape, and color. Therefore, three parameters are employed, i.e. N/C ratio, wavelet approximation coefficients, and color intensity. Based on thorough observation upon the selected parameters, it can be recognized that the cancerous cells follow certain patterns and highly distinguishable from the normal cells.

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Cited by 30 publications

References 7 publications

Human papillomavirus detection in moroccan patients with nasopharyngeal carcinoma

Human papillomavirus detection in moroccan patients with nasopharyngeal carcinoma

Multiple Sclerosis, Lymphoma and Nasopharyngeal Carcinoma: The Central Role of Epstein-Barr Virus?

Pattern recognition on 2D cervical cytological digital images for early detection of cervix cancer

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