900 MHz pulse-modulated radiofrequency radiation induces oxidative stress on heart, lung, testis and liver tissue

Eşmekaya, Meriç Arda; Özer, Çiğdem; Seyhan, Nesrin

doi:10.4149/gpb_2011_01_84

Cited by 83 publications

(50 citation statements)

References 28 publications

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“…Malondialdehyde level was found to be increased in various organs of animals exposed to MWs (19)(20)(21)24,25) including liver (22,26,27). Our results show as well, that MDA levelsare increased in liver tissue of rats exposed to microwaves after prolonged exposition period (40 and 60 days).…”

Section: Disscusionsupporting

confidence: 70%

“…The observed increase in MDA level was, according to our results, dependent on the exposure duration. However, we failed to demonstrate the signifi cant change in MDA level in animals exposed to MWs for 20 days, previously reported by (27), probably due to the differences in average SAR (0,09 W/ kg vs 1,2 W/kg) and experimental set up. Melatonin administration to irradiated animals ameliorated the radiation effect on lipid peroxidation in the liver tissuein a signifi cant level.Changes in MDA level in group both irradiated and treated with melatonin occurred simultaneously with the increase in MDA level in irradiated group.…”

Section: Disscusioncontrasting

confidence: 50%

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The effect of melatonin on the liver of rats exposed to microwave radiation

Djordjević¹,

Sokolović²,

Kocić³

et al. 2015

BLL

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Abstract:Objectives: We aimed to clarify if melatonin treatment (2 mg/kg i.p.) may favorably impact the liver tissue in rats exposed to microwave radiation. The experiment was performed on 84 six-weeks-old Wistar male rats exposed for 4h a day, for 20, 40 and 60 days, respectively, to microwaves (900 MHz, 100-300 microT, 54-160 V/m). Rats were divided in to four groups: I (control) -rats treated with saline, II (Mel) -rats treated with melatonin, III (MWs) -microwave exposed rats, IV (MWs + Mel) -MWs exposed rats treated with melatonin. We evaluated oxidative stress parameters (malondialdehyde and carbonyl group content), catalase, xanthine oxidase, deoxyribonuclease I and II activity. Background: Oxidative stress is the key mechanism of the microwave induced tissue injury. Melatonin, a lipophilic indoleamine primarily synthesized and released from the pineal gland is a powerful antioxidant. Results: Exposure to microwaves caused an increase in malondialdehyde after 40 (p < 0.01), protein carbonyl content after 20 (p < 0.05), catalase (p < 0.05) and xantine oxidase activity (p < 0.05) after 40 days. Increase in deoxyribonuclease I activity was observed after 60 days (p < 0.05), while deoxyribonuclease II activity was unaffected. Melatonin treatment led to malondialdehyde decrease after 40 days (p< 0.05), but surprisingly had no effect on other analyzed parameters. Conclusion: Melatonin exerts certain antioxidant effects in the liver of rats exposed to microwaves, by diminishing the intensity of lipid peroxidation (Fig. 6, Ref. 32).Text in PDF www.elis.sk.

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Section: Disscusionsupporting

confidence: 70%

Section: Disscusioncontrasting

confidence: 50%

The effect of melatonin on the liver of rats exposed to microwave radiation

Djordjević¹,

Sokolović²,

Kocić³

et al. 2015

BLL

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“…Therefore, stimulation of the immune system may be a key mechanism for the induction of adaptive response. On the other hand, some recent studies showed that radiofrequency radiation causes oxidative injury in different tissues mediated by lipid peroxidation, increased level of nitric oxide (NO), and suppression of antioxidant defense mechanism (Esmekaya et al 2011, Ozgur et al 2010. Feinendegen et al (1996Feinendegen et al ( , 1999, in their previous studies, proposed that adaptive response could be induced by reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Non-Linear Adaptive Phenomena which Decrease the Risk of Infection after Pre-Exposure to Radiofrequency Radiation

et al. 2013

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Substantial evidence indicates that adaptive response induced by low doses of ionizing radiation can result in resistance to the damage caused by a subsequently high-dose radiation or cause cross-resistance to other non-radiation stressors. Adaptive response contradicts the linear-non-threshold (LNT) dose-response model for ionizing radiation. We have previously reported that exposure of laboratory animals to radiofrequency radiation can induce a survival adaptive response. Furthermore, we have indicated that pre-exposure of mice to radiofrequency radiation emitted by a GSM mobile phone increased their resistance to a subsequent Escherichia coli infection. In this study, the survival rates in animals receiving both adapting (radiofrequency) and challenge dose (bacteria) and the animals receiving only the challenge dose (bacteria) were 56% and 20%, respectively. In this light, our findings contribute to the assumption that radiofrequency-induced adaptive response can be used as an efficient method for decreasing the risk of infection in immunosuppressed irradiated individuals. The implication of this phenomenon in human's long term stay in the space is also discussed.

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“…EMF inhibited MnSOD expression in the rat testis and induced oxidative stress on heart, lung, testis and liver tissues and testicular apoptosis [32][33][34]. Related animal study has also shown that exposure to ELF induced males mice spermatagonial cells apoptosis [35].…”

Section: Discussionmentioning

confidence: 99%

Effects of extremely low-frequency electromagnetic fields (ELF-EMF) exposure on B6C3F1 mice

Zuo

Zhou

et al. 2015

Environ Health Prev Med

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Objective Long-term exposure study was conducted to investigate the effects of extremely low-frequency electromagnetic field on the tumor promotion process and fertility. Methods Ten pregnant C57BL/6NCrj mice were exposed to 50 Hz field 500 mG for 1 week (12 h per day), and 24 male and 42 female B6C3F1mice born from them were further exposed up to 15.5 months. As a control group, 10 pregnant mice were bred without exposure, and 30 produced male and 32 female mice were observed without exposure for the same period. Results Mean body weights of exposed groups of male and female mice were decreased significantly than those of the control groups. In exposed mice, there was no increased incidence of liver and lung tumor. In female mice, the incidence of chronic myeloid leukemia [3/42 (7 %)] in the exposed group was significantly greater than in the control group. The size of seminiferous tubules in the EMF exposed groups were significantly less than the control group. Conclusions These data support the hypothesis that longterm exposure of 50 Hz magnetic fields is a significant risk factor for neoplastic development and fertility in mice.

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900 MHz pulse-modulated radiofrequency radiation induces oxidative stress on heart, lung, testis and liver tissue

Cited by 83 publications

References 28 publications

The effect of melatonin on the liver of rats exposed to microwave radiation

The effect of melatonin on the liver of rats exposed to microwave radiation

Non-Linear Adaptive Phenomena which Decrease the Risk of Infection after Pre-Exposure to Radiofrequency Radiation

Effects of extremely low-frequency electromagnetic fields (ELF-EMF) exposure on B6C3F1 mice

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