962. Congeners of pyridine-4-carboxyhydrazide. Part II. Derivatives of 1,2,3-thiadiazole

Synthesis of substituted 2λ4δ2-[1,2,3]thiadiazolo[3,4-c]benzimidazoles and 2λ4δ2-[1,2,3,5]thiatriazolo[3,4-c]benzimidazoles

“…14 To determine the properties of compounds 1 and Table 1. Data of the bromination reactions of 3-chloro [1,2,3]thiadiazolo [3,4-c]benzimidazole (1) and [1,2,3,5]thiatriazolo [3,4- …”

“…6,7 1,2,3-Thiadiazoles are also valuable as synthetic intermediates for substituted acetylenes, [8][9][10] thioamides, 11 5-aryloxy(thio)-1,2,3-thiadiazoles 12 and other heterocyclic systems. 13 We have reported previously the synthesis of the first representatives of a fused heterocyclic system containing the 1,2,3-thiadiazole moiety - [1,2,3]thiadiazolo [3,4-c]benzimidazole. 14 The aim of this study is to investigate the synthesis and reactivity of 3-chloro [1,2,3]thiadiazolo [3,4-c]benzimidazole (1) and its aza-analog, [1,2,3,5]thiatriazolo [3,4-c]benzimidazole 15 (2), with substituents on the benzene ring.…”

“…1,2,3-Thiadiazoles are of substantial interest in medicinal chemistry for treatment of thromboses, 1 as antibacterials, [2][3][4] platelet-activating factors, 5 in agricultural chemistry as plant growth activators, and inducers of systemic acquired resistance (SAR) in plants. 6,7 1,2,3-Thiadiazoles are also valuable as synthetic intermediates for substituted acetylenes, [8][9][10] thioamides, 11 5-aryloxy(thio)-1,2,3-thiadiazoles 12 and other heterocyclic systems.…”

Thiadiazoles

“…Thus, 1,2,3-triazolo [4,5-b] [55], or by hydrolysis of the corresponding esters [56]. The acids can be easily converted by standard procedures into the corresponding esters, chlorides, amides, hydrazides, azides, thioamides, and nitriles [36,57].…”

Synthesis and antibacterial activity of some new pyrazolone dyes

“…In addition, both thia-and selenadiazoles are known through their antibacterial activities. [4][5][6] In spite of many reports on the synthesis and biological activity of pyrazolone d y e~,~-l~ none of these dyes involved the 1,2,3-thia-or selenadiazole ring in its structure. Consequently, it seemed of interest to synthesise these latter dyes in the hope that some of them might show improved antimicrobial properties.…”