99MTc-diphosphonate uptake in neuroblastoma

Imaging of neuroblastoma: an overview

“…At least 60% of patients with neuroblastoma will have primary tumor uptake of Tc-99m-labeled phosphate compounds (Fig.10B). The mechanism of this is not known but it does not correlate with extent of calcification or degree of tissue necrosis [4,52,53,56,63,78]. If there is uptake of skeletal tracer by an abdominal or thoracic mass, the possibility of neuroblastoma should be strongly considered.…”

Bone Scanning in Clinical Practice

“…What little evidence is available suggests that this is an unimportant consideration (McCartney et al 1976).…”