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Ig, Makarenko; Mv, Ugriumov; Kalas, A.

doi:10.1023/a:1013873012416

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…without discrimination between OT and AVP) fibers in the posterior pituitary. Another study by the Michael Ugrumov and André Calas groups (Makarenko et al, 2000, 2002), employing DiI-based retrograde tracing in fixed brains, showed certain dynamics of these projections: first connections between the main part of the SON and pituitary are established earlier (detected at E15—earliest time point of the experiment), while the PVN and retrochiasmatic parts of the SON project to the pituitary later—at E17 (Makarenko et al, 2000). Intriguingly, the AN, composed mostly of OT neurons, projects to the pituitary only after birth (Makarenko et al, 2002).…”

Section: Establishment Of Ot Circuitrymentioning

confidence: 99%

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Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders

et al. 2015

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Oxytocin (OT), the main neuropeptide of sociality, is expressed in neurons exclusively localized in the hypothalamus. During the last decade, a plethora of neuroendocrine, metabolic, autonomic and behavioral effects of OT has been reported. In the urgency to find treatments to syndromes as invalidating as autism, many clinical trials have been launched in which OT is administered to patients, including adolescents and children. However, the impact of OT on the developing brain and in particular on the embryonic and early postnatal maturation of OT neurons, has been only poorly investigated. In the present review we summarize available (although limited) literature on general features of ontogenetic transformation of the OT system, including determination, migration and differentiation of OT neurons. Next, we discuss trajectories of OT receptors (OTR) in the perinatal period. Furthermore, we provide evidence that early alterations, from birth, in the central OT system lead to severe neurodevelopmental diseases such as feeding deficit in infancy and severe defects in social behavior in adulthood, as described in Prader-Willi syndrome (PWS). Our review intends to propose a hypothesis about developmental dynamics of central OT pathways, which are essential for survival right after birth and for the acquisition of social skills later on. A better understanding of the embryonic and early postnatal maturation of the OT system may lead to better OT-based treatments in PWS or autism.

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Section: Establishment Of Ot Circuitrymentioning

confidence: 99%

“…Furthermore, many OT neurons project axons to the posterior pituitary only after birth (Makarenko et al, 2002) and no collaterals of OT axons have been reported in extrahypothalamic brain regions of neonates in contrast to those in adult rodents (Knobloch and Grinevich, 2014). …”

Section: Ot Pathways In Perinatal Ontogenesis: Physiology Pathologymentioning

confidence: 99%