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Giron, D.; Goldbronn, C.; Mutz, Michael; Pfeffer, Sabine; Piéchon, Philippe; Schwab, P. A.

doi:10.1023/a:1016031517430

Cited by 112 publications

(32 citation statements)

References 21 publications

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“…Furthermore, drug substances and drug products are submitted to different temperatures and relative humidities during storage (namely, due to climatic conditions), giving rise to unexpected hydration or dehydration aging phenomena that are known to affect several drug properties, such as solubility, dissolution rate, stability, and bioavailability. 12,44 As described above, the exposure to extreme RH values (0 and 100%) results in total NCa $ NCh interconversion in substantially less than 2 weeks. However, at intermediate RH values, the same processes were found to occur in a much larger time scale.…”

Section: Critical Rh For Hydration/dehydration Processmentioning

confidence: 88%

Pseudopolymorphic transitions of niclosamide monitored by Raman spectroscopy

Sardo¹,

Amado²,

Ribeiro‐Claro³

2008

J Raman Spectroscopy

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Niclosamide suffers pseudopolymorphic transformations when exposed to different ambient conditions, which can lead to changes in its bioavailability. In this study, the kinetics of the pseudopolymorphic transitions of niclosamide crystals are characterized. FT-Raman spectroscopy is used to quantify the anhydrate and hydrate forms of niclosamide crystals, mostly because of its high sensitivity to the strong intermolecular interactions present in these systems. The samples are exposed to well-characterized relative humidity (RH) conditions during different periods of time and both water diffusion and polymorphic changes are monitored from the corresponding changes observed in the vibrational spectra. Both hydration and dehydration were found to be single-step processes, with a half-life time of ca. 142 and 63 h, respectively, at 24°C.

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Section: Critical Rh For Hydration/dehydration Processmentioning

confidence: 88%

Pseudopolymorphic transitions of niclosamide monitored by Raman spectroscopy

Sardo¹,

Amado²,

Ribeiro‐Claro³

2008

J Raman Spectroscopy

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“…It was observed that for the TG performed at 1 • C min −1 the water content was released at a lower temperature (90-125 • C; DTG peak 117.49 • C). Since the intermolecular force (hydrogen bonding) can lead to very strong water-solid interactions, a slower heating rate facilitates the dehydration process [29].…”

Section: Thermal Analysismentioning

confidence: 99%

Physico-chemical solid-state characterization of omeprazole sodium: Thermal, spectroscopic and crystallinity studies

Murakami

Lang

Mendes

et al. 2009

Journal of Pharmaceutical and Biomedical Analysis

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“…During processing into tablets or capsules, APIs are subjected to different humidities, pressures, and temperatures that may alter their solid form. 1, 8 Choosing the most soluble form of a drug may allow it to change forms once processed and could lead to non-uniformity of dosage. For example, the use of moxifloxacin hydrochloride led to inconsistent active content during administration, a problem that was overcome with use of a novel hydrate.…”

mentioning

confidence: 99%