The proliferation of personal artificial intelligence (AI) -assistant technologies with speech-based conversational AI interfaces is driving the exponential growth in the consumer Internet of Things (IoT) market. As these technologies are being applied to keyword spotting (KWS), automatic speech recognition (ASR), natural language processing (NLP), and text-to-speech (TTS) applications, it is of paramount importance that they provide uncompromising performance for context learning in long sequences, which is a key benefit of the attention mechanism, and that they work seamlessly in polyphonic environments. In this work, we present a 25-mm 2 system-on-chip (SoC) in 16-nm FinFET technology, codenamed SM6, which executes end-to-end speech-enhancing attention-based ASR and NLP workloads. The SoC includes: 1) FlexASR, a highly reconfigurable NLP inference processor optimized for whole-model acceleration of bidirectional attention-based sequence-to-sequence (seq2seq) deep neural networks (DNNs); 2) a Markov random field source separation engine (MSSE), a probabilistic graphical model accelerator for unsupervised inference via Gibbs sampling, used for sound source separation; 3) a dual-core Arm Cortex A53 CPU cluster, which provides on-demand single Instruction/multiple data (SIMD) fast fourier transform (FFT) processing and performs various application logic (e.g., expectation-maximization (EM) algorithm and 8-bit floating-point (FP8) quantization); and 4) an always-ON M0 subsystem for audio detection and power management. Measurement results demonstrate the efficiency ranges of 2.6-7.8 TFLOPs/W and 4.33-17.6 Gsamples/s/W for FlexASR and MSSE, respectively; MSSE denoising performance allowing Manuscript