A 12-month study of policosanol oral toxicity in Sprague Dawley rats

Alemán, Celia; R, Más; Hernández, Caridad; Rodeiro, Idania; Cerejido, E; Noa, Miríam; Capote, Amelia; Menéndez, Roberto; Amor, Ana María; Fraga, V.

doi:10.1016/0378-4274(94)90147-3

Cited by 90 publications

(47 citation statements)

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“…Given the range and breadth of actions of Metadichol the results suggest that it mimics the effects of 1,25-dihydroxy Vitamin D3 but without the toxic effect secondary to Calcemia that has its use as a pharmaceutical agent [30]. Metadichol is the first example of a smart molecule that can simultaneously modulate multiple targets which can with Metadichol can lead potentially to a successful treatment of many of these challenging diseases [31][32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Rheumatoid Arthritis and Osteoporosis: A Case Study

Raghavan¹

2017

J Arthritis

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Metadichol ® is a Nano emulsion of long-chain alcohols called as Policosanol and is present in foods such as rice, sugar cane, wheat, and peanuts. Metadichol ® acts on Nuclear Vitamin D receptors (VDR) that are present in cells throughout the body to stimulate the immune system and inhibit a variety of disease processes, resulting from inflammation to infection [1].We present a case study of a patient with Rheumatoid arthritis with the high levels of RF antibodies, CRP and ESR levels, and low bone mineral density leading to osteoporosis. The case report shows how Metadichol ® by its actions on the VDR has affected key biomarkers and mitigated the disease conditions without any side effects. Also, his bone density improved dramatically.Metadichol ® is safe because it consists of natural components of conventional foods and has no known adverse side effects. Its constituents are present in many foods that we consume every day.Metadichol ® has the potential to serve as a novel, safe solution to help patients with RA and other autoimmune diseases that confront the world today.

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Section: Discussionmentioning

confidence: 99%

Rheumatoid Arthritis and Osteoporosis: A Case Study

Raghavan¹

2017

J Arthritis

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“…Metadichol has the potential to be an anti-inflammatory molecule with a broad spectrum of activity. Its constituents (long-chain lipid alcohols) are present in foods commonly consumed on a daily basis and with no toxicity seen even with doses of up to 5000 mg/kg [18][19]. Metadichol could be used as a nutritional…”

Section: Discussionmentioning

confidence: 99%

“…All the three patients have shown improvements in various biomarkers like Creatinine, PTH, and ferritin and will be reported in due course. No adverse side effects have since Metadichol® is a natural food-based product that is completely safe [18][19].…”

Section: Discussionmentioning

confidence: 99%

Metadichol® and Red Cell Distribution Width (RDW) in CKD patients

PR¹

2017

J Stem Cell Res Ther

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“…To our knowledge, this is the first basic research on the pharmacodynamic action of octacosanol in neurodegenerative diseases such as PD and our studies provide strong evidences for the novel theory that the proNGF-p75NTR-Sortilin signalling complex may provide a new molecular target for the therapeutic treatment of Parkinson's disease. And furthermore, because of the non-toxicity in animal studies [55] and its excellent tolerability in clinical trials [56] , it would be feasible and beneficial for the healthy general population to use octacosanol without major side effects or regular physician monitoring. Thus, octacosanol may be a neuroprotective and promising agent for PD treatment.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling

et al. 2010

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Aim: To investigate the protective effects of octacosanol in 6-hydroxydopamine-induced Parkinsonian rats and find whether octacosanol has effects on pro nerve growth factor (pro-NGF), NGF and the downstream effector proteins. Methods: Behavioral tests, enzymatic assay, tyrosine hydroxylase immunohistochemistry, TUNEL and Western blot were used to investigate the effects of octacosanol in this rat model of PD. Results: Oral administration of octacosanol (35-70 mg/kg, po for 14 d) significantly improved the behavioral impairments in rats induced by 6-OHDA and dose-dependently preserved the free radical scavenging capability of the striatum. Octacosanol treatment also effectively ameliorated morphological appearances of TH-positive neuronal cells in nigrostriatal systems and decreased the apoptotic cells induced by 6-OHDA in striatum. In addition, octacosanol strikingly blocked the 6-OHDA-induced increased expression of proNGFp75NTR-sortilin death signaling complex and its downstream effector proteins. Meantime, octacosanol prevented the decreased levels of NGF, its receptors TrkA and p-Akt which together mediated the cell survival pathway. Conclusion: The findings implicated that the anti-parkinsonism effects afforded by octacosanol might be mediated by its neuro-microenvironment improving potency through retrieving the ratios of proNGF:NGF and the respective receptors p75NTR:TrkA in vivo. Due to its excellent tolerability and non-toxicity, octacosanol may be a promising agent for PD treatment.

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A 12-month study of policosanol oral toxicity in Sprague Dawley rats

Cited by 90 publications

References 0 publications

Rheumatoid Arthritis and Osteoporosis: A Case Study

Rheumatoid Arthritis and Osteoporosis: A Case Study

Metadichol® and Red Cell Distribution Width (RDW) in CKD patients

Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling

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