A 15-year series of gastrointestinal non-Hodgkin's lymphomas: a population-based study

Ducreux, Michel; Boutron, M C; Piard, F; Carli, P. M.; Faivre, Jean

doi:10.1038/bjc.1998.82

Cited by 47 publications

(26 citation statements)

References 25 publications

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“…In regard to the frequencies of the primary extranodal presentation our study demonstrated that the stomach was the most commonly involved site as reported by many studies [20, 21, 22]. The analysis of the histological distribution of the various WHO classification subtypes, among extranodal places, showed that MALT B cell lymphomas were found in almost half of the patients with GI tract lymphomas, whereas in all other extranodal places DLCL was the predominant histological subtype.…”

Section: Discussionsupporting

confidence: 56%

Non-Hodgkin’s Lymphomas in Greece according to the WHO Classification of Lymphoid Neoplasms

et al. 2005

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The purpose of this retrospective study, the largest unselected series in our country, was to illustrate the clinicopathological features of non-Hodgkin’s lymphoma (NHL) classified according to the World Health Organization (WHO) classification of lymphoid neoplasms. A retrospective analysis was conducted and clinical features of histological subtypes were established in 810 patients (age ≧15 years) with NHL who were treated at 8 major centers representative of Greece. There were 435 males and 375 females 95% of them aged >30 years. B symptoms were present in 34% of the patients, while 45.3% had stages I–II and 54.6% had stages III–IV. LDH was increased in 37% of the patients. B cell lymphomas formed 88% of the cases whereas T cell lymphomas formed 12% of the total. Indolent lymphomas accounted for 31.1%, aggressive ones for 66.7% and very aggressive ones for 2.4% of all NHLs. Among indolent lymphomas extranodal ones (MALT B cell lymphoma) were the most common subset while follicular lymphoma grade I and II and small lymphocytic ones presented with equal frequency. Among the aggressive lymphomas diffuse large cell lymphoma (DLCL) was the most common subtype; this entity along with large-cell immunoblastic lymphomas accounted for 45.2% of all B cell lymphomas. Among the T cell lymphomas, peripheral T cell lymphomas and anaplastic large cell lymphomas of the T/null-cell type were the most common subtypes. The most common extranodal presentation was the gastrointestinal tract (GI). Next in frequency were primary extranodal NHL of the head and neck region. MALT B cell lymphomas were found in almost half of the patients with GI tract NHL, whereas in all other extranodal places DLCL was the predominant histological subtype. The median survival for indolent and aggressive NHL was 123.5 and 55.5 months, respectively. This is the first report of a large series of malignant lymphomas in Greece using the WHO classification. It appears that there are no significant differences between NHL in Greece and other large series as far as clinical and extranodal presentation is concerned. The frequency of follicular lymphoma in the current study is comparable to that reported from Asian countries and mainland Europe, but lower than that of US and Northern European series. There were no important differences in the incidence of the remaining histological subtypes between Greece and other European countries.

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Section: Discussionsupporting

confidence: 56%

Non-Hodgkin’s Lymphomas in Greece according to the WHO Classification of Lymphoid Neoplasms

et al. 2005

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“…The principal disadvantages are those shared by similar studies in that it is not known whether all extranodal disease has been included, the site may be vague in some cases and it is not always possible to distinguish a nodal condition infiltrating into the bowel from primary bowel disease. The incidence rates found in this study for gastrointestinal NHL in parts of England and Wales are lower than those reported by previous population-based studies in France, central Finland and Denmark (D'Amore et al, 1994;Halme et al, 1997;Ducreux et al, 1998). This difference is more marked for gastric NHL, where incidence is less than half that found in other European countries, than for intestinal NHL where the rates are more similar to those reported.…”

Section: Discussioncontrasting

confidence: 55%

“…A hospital-based series reviewed by Weingrad et al (1982) found that 73% of patients had a primary gastric lymphoma but this series did not include children who typically have relatively more intestinal disease than adults. In other studies, a greater proportion of large bowel to small bowel NHL probably reflects the inclusion of mesenteric presentations in the former group, whilst in this study these have been recorded as nodal disease and have not been included in the analyses for gastrointestinal NHL (Otter et al, 1989b;Ducreux et al, 1998). In addition, there is considerable evidence that geographical variation exists.…”

Section: Discussionmentioning

confidence: 83%

Descriptive epidemiology of gastrointestinal non-Hodgkin’s lymphoma in a population-based registry

1999

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SummaryThe incidence of non-Hodgkin's lymphoma (NHL), particularly at certain extranodal sites, has been demonstrated to be rising, at least in the USA, more than for any other malignancy. One of the major sites of extranodal NHL is the gastrointestinal tract, though little is known of its epidemiological characteristics. Over an 8-year period (1986 to 1993) 1069 primary gastrointestinal NHL cases were reported to the Leukaemia Research Fund Data Collection Survey which covers many parts of England and Wales. Age-standardized incidence rates of gastrointestinal NHL at all sites (0.58/10 5 per year), gastric (0.24/10 5 per year), small bowel (0.17/10 5 per year) and large bowel (0.06/10 5 per year) confirmed that the UK has the lowest rates of gastrointestinal NHL in Europe. An excess of males was observed at all ages and for all sites. Time-trend analyses showed annual increases in incidence rates for gastric (6.3%) and small bowel (5.9%) NHL although a concomitant decrease in gastrointestinal NHL of unknown site suggested that at least part of these increases had resulted from more accurate diagnoses. Overall, the incidence of gastrointestinal NHL significantly increased by 2.7% per annum and was limited to the population aged over 50 years in this series.

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“…Only lymphoma of the thyroid was more common in women (0.4:1) excluding sex-specific sites. For gastrointestinal NHL [22], found in a 15-year series in France, an age-standardized incidence rate of 0.94 per 100,000 for men, and a significantly smaller increase of 0.54 per 100,000 for women was seen. In our study the male to female ratio, both in the adult age group (2.1:1) and in the pediatric group (2.0:1), was shifted towards a significantly higher percentage of male patients.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Features of Extranodal Lymphomas: Kuwait Experience

et al. 2004

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A total of 935 patients with extranodal non-Hodgkin lymphoma (NHL) diagnosed in the period between January 1985 and December 2000 in Kuwait Cancer Center, serving the whole population of Kuwait, were used to describe the clinicopathological and epidemiological features of extranodal lymphomas in Kuwait. Extranodal lymphomas accounted for 45% of all NHL observed during this time. All NHL cases from Kuwait Cancer registry were analyzed and pathologically reclassified using the latest WHO (2000) classification. The most common lymphoma observed was diffuse large B-cell lymphoma (58.60%) followed by Burkitt´s lymphoma (BL) (3.80%). In the pediatric group, BL comprises more than two thirds of all patients (77.20%). The most common extranodal sites were stomach (19.70%) and skin (17.80%) in the adult group, large intestine (29.80%) and small intestine (19.30%) in the pediatric age group. The majority (73.40%) of adult extranodal lymphomas was in stage IE–IIE and had a very good prognosis. On the contrary, the majority of pediatric extranodal lymphomas were found to be in stage III and IV. Variations in treatment policies (single agent or combined chemotherapy, radiotherapy, combined modality treatment) adopted and changed during the time period of 16 years of this retrospective study were documented.

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A 15-year series of gastrointestinal non-Hodgkin's lymphomas: a population-based study

Cited by 47 publications

References 25 publications

Non-Hodgkin’s Lymphomas in Greece according to the WHO Classification of Lymphoid Neoplasms

Non-Hodgkin’s Lymphomas in Greece according to the WHO Classification of Lymphoid Neoplasms

Descriptive epidemiology of gastrointestinal non-Hodgkin’s lymphoma in a population-based registry

Clinicopathological Features of Extranodal Lymphomas: Kuwait Experience

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