Descriptive epidemiology of gastrointestinal non-Hodgkin’s lymphoma in a population-based registry

Abstract

SummaryThe incidence of non-Hodgkin's lymphoma (NHL), particularly at certain extranodal sites, has been demonstrated to be rising, at least in the USA, more than for any other malignancy. One of the major sites of extranodal NHL is the gastrointestinal tract, though little is known of its epidemiological characteristics. Over an 8-year period (1986 to 1993) 1069 primary gastrointestinal NHL cases were reported to the Leukaemia Research Fund Data Collection Survey which covers many parts of England and Wales. Age-standardized incidence rates of gastrointestinal NHL at all sites (0.58/10 5 per year), gastric (0.24/10 5 per year), small bowel (0.17/10 5 per year) and large bowel (0.06/10 5 per year) confirmed that the UK has the lowest rates of gastrointestinal NHL in Europe. An excess of males was observed at all ages and for all sites. Time-trend analyses showed annual increases in incidence rates for gastric (6.3%) and small bowel (5.9%) NHL although a concomitant decrease in gastrointestinal NHL of unknown site suggested that at least part of these increases had resulted from more accurate diagnoses. Overall, the incidence of gastrointestinal NHL significantly increased by 2.7% per annum and was limited to the population aged over 50 years in this series.

Primary gastrointestinal lymphoma in Japan

“…However, most of these studies analyzed a small number of subjects and only five recruited more than 300 patients. 2,17,[23][24][25] The current study is the second largest series, which follows an earlier study by Freeman et al 2 Table 6 shows the primary site of gastrointestinal lymphoma in five studies, 2,17,[23][24][25] together with a larger population-based report by Gurney et al 37 The most common primary site was the stomach with a frequency ranging from 44% to 75%. In our series, the gastric group comprised 75% of all patients.…”

“…2,23,24,37 Geographic variations in the prevalence of H. pylori infection, celiac disease, or other environmental factors may be the cause of the difference. 35,38,39 In Middle Eastern countries, the frequency of intestinal lymphoma is high (range, 49 -81%).…”

“…Increasing exposure or susceptibility to risk factors, such as H. pylori infection, ultraviolet light, chemicals, and excessive protein or fat in the diet, also may have contributed to this increase. 37,38 In Period C (1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002), both the number and the proportion of low-grade B-cell lymphoma increased. This is attributable to an increase in the diagnosis of gastric MALT lymphoma by endoscopy with biopsy.…”

Complete remission of gastric Burkitt’s lymphoma aftereradication of Helicobacter pylori

“…The stomach is the most common site of extranodal malignant lymphomas, constituting 30%-45% of all extranodal malignant lymphoma and 1%-7% of all gastric malignancies [1] . The most common gastric lymphomas are extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue (MALT), characterized by an infiltration of the mucosa by centrocyte-like B-cells associated with lymphoepithelial lesions, and diffuse large B cell lymphomas (DLBCL) [2] .…”

Primary gastrointestinal Non Hodgkin′s lymphoma chemotherapy alone an effective treatment modality: Experience from a single centre in India

“…[ Table 5] summarizes anatomic location of the initial disease in the GI tract reported in recent studies. [2,3,8,9,22,23] In the majority of the studies, stomach is the commonest site of involvement. With the introduction of the entity MALT lymphoma by Issacson, more and more gastric MALT lymphomas are diagnosed.…”