A 20-week randomized controlled trial of estradiol replacement therapy for women aged 70 years and older: Effect on mood, cognition and quality of life

Almeida, Osvaldo P.; Lautenschlager, Nicola T.; Vasikaran, Samuel; Leedman, Peter; Gelavis, Anna; Flicker, Leon

doi:10.1016/j.neurobiolaging.2004.12.012

Cited by 107 publications

(82 citation statements)

References 36 publications

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“…[32][33][34][35] Finally, a series of case-control and cohort studies evaluated the effect of estrogen treatment after menopause, regardless of the cause of menopause. They reported a 20-40% reduction in the risk of Alzheimer's disease for women starting estrogen therapy early after menopause compared with those not taking estrogen.…”

Section: Cognitive Impairment or Dementiamentioning

confidence: 99%

Prophylactic oophorectomy in premenopausal women and long-term health

Shuster¹,

Gostout²,

Grossardt³

et al. 2008

Menopause International

218

136

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Objective-To review the data on long-term outcomes in women who underwent prophylactic bilateral oophorectomy, a common surgical procedure that has more than doubled in frequency since the 1960s.Study design-Literature review of published data on consequences of prophylactic bilateral oophorectomy. Special emphasis was given to the Mayo Clinic Cohort Study of Oophorectomy and Aging.Main outcome measures-Overall mortality, cardiovascular disease, cognitive impairment and dementia, parkinsonism, osteoporosis, psychological well-being, and sexual function.Results-There is a growing body of evidence suggesting that the premature loss of ovarian function caused by bilateral oophorectomy performed before natural menopause is associated with several negative outcomes. In particular, studies have revealed an increased risk of premature death, cardiovascular disease, cognitive impairment or dementia, parkinsonism, osteoporosis and bone fractures, decline in psychological well-being, and decline in sexual function. The effects involve different organs (e.g., heart, bone, or brain), and different functions within organs (e.g., cognitive, motor, or emotional brain functions). Estrogen treatment may prevent some of these negative outcomes, but not all. Conclusion-The potential adverse effects of prophylactic bilateral oophorectomy on heart health, neurologic health, bone health, and quality of life should be carefully weighed against its potential benefits for cancer risk reduction in women at average risk of ovarian cancer.

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Section: Cognitive Impairment or Dementiamentioning

confidence: 99%

Prophylactic oophorectomy in premenopausal women and long-term health

Shuster¹,

Gostout²,

Grossardt³

et al. 2008

Menopause International

218

136

View full text Add to dashboard Cite

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“…In prior studies where the subjects were younger than 65 when they started estrogen therapy, beneficial effects were seen (Joffe et al 2006;Phillips and Sherwin 1992;Shaywitz et al 2003;Sherwin 1996;Woo et al 2003). In addition to the WHI/WHIMS study, other studies with women over 65 have shown no benefit of estrogen treatment (Almeida et al 2006;Viscoli et al 2005;Yaffe et al 2006). These findings have led to the proposal of a critical period for an estrogen benefit on cognition (Maki 2006;Resnick and Henderson 2002;Sherwin 2007).…”

Section: Introductionmentioning

confidence: 98%

Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: Evidence for the critical period hypothesis

Dumas

Hancur-Bucci

Naylor

et al. 2008

Hormones and Behavior

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Estradiol has been shown to interact with the cholinergic system to affect cognition in postmenopausal women. This study further investigated the interaction of estradiol and cholinergic system functioning on verbal memory and attention in two groups of healthy younger (ages 50-62) and older (ages 70-80) postmenopausal women. Twenty-two postmenopausal women were randomly and blindly placed on 1 mg of 17-beta estradiol orally for one month then 2 mg for two months or matching placebo pills after which they participated in three anticholinergic challenge sessions when verbal memory performance was assessed. Subjects were administered either the antimuscarinic drug scopolamine (SCOP), the antinicotinic drug mecamylamine (MECA) or placebo. After the first challenge phase, they were crossed over to the other hormone treatment for another three months and repeated the challenges. Results showed that estradiol pretreatment significantly attenuated the anticholinergic drug-induced impairments on a test of episodic memory (the Buschke Selective Reminding test) for the younger group only, while estradiol treatment impaired performance of the older group. The results suggest that younger subjects may experience more cholinergic benefit from estradiol treatment than older subjects, supporting the concept of a critical period for postmenopausal estrogen use.

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“…The results of previous studies suggest that estrogen replacement therapy may be associated with better mood, cognitive function and quality of life through promoting neuronal sprouting, enhancing cholinergic activity, decreasing brain and plasma levels of betaamyloid as discussed before (Almeida et al, 2006). Estrogen probably may have a protective role in cognitive decline in AD (Jamshed et al, 2014).…”

Section: Discussionmentioning

confidence: 95%

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

Ghofrani

Joghataei

Mohseni

et al. 2015

European Journal of Pharmacology

151

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Alzheimer's disease (AD) is one of the prevalent neurological disorders of the central nervous system hallmarked by increased beta-amyloid (Aβ) deposition and ensuing learning and memory deficit. In the present study, the beneficial effect of naringenin on improvement of learning and memory was evaluated in an Alzheimer's disease rat model. The Aβ-injected rats showed a lower alternation score in Y-maze task, impairment of retention and recall capability in passive avoidance test, and lower correct choices and higher errors in radial arm maze (RAM) task as compared to sham group in addition to enhanced oxidative stress and apoptosis. Naringenin, but not a combination of naringenin and fulverstrant (an estrogenic receptor antagonist) significantly improved the performance of Aβ-injected rats in passive avoidance and RAM tasks. Naringenin pretreatment of Aβ-injected rats also lowered hippocampal malondialdehyde (MDA) with no significant effect on nitrite and superoxide dismutase (SOD) activity in addition to lowering apoptosis. These results suggest naringenin pretreatment attenuates Aβ-induced impairment of learning and memory through mitigation of lipid peroxidation and apoptosis and its beneficial effect is somewhat mediated via estrogenic pathway.

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A 20-week randomized controlled trial of estradiol replacement therapy for women aged 70 years and older: Effect on mood, cognition and quality of life

Cited by 107 publications

References 36 publications

Prophylactic oophorectomy in premenopausal women and long-term health

Prophylactic oophorectomy in premenopausal women and long-term health

Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: Evidence for the critical period hypothesis

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

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