A 3-Year Clinical Trial of Calcium Carbonate Dentifrice Containing Calcium Glycerophosphate and Sodium Monofluorophosphate

Monofluorophosphate (MFP) dentifrices have been tested extensively in clinical trials in the last 2 decades. This paper reviews findings in these studies. The average benefit seems to be about 25% and has not changed with time. The benefit is the same in fluoridated and nonfluoridated areas. MFP is compatible with calcium-containing abrasives and calcium ion. There is a possibility that use of calcium-containing MFP dentifrices of optimal formulation may be particularly beneficial. There seems to be a relationship between F concentration and benefit derived. Supervised and unsupervised use of MFP dentifrices results in comparable benefits. The relative efficacy of NaF and MFP dentifrices is not known. It may be advantageous to combine MFP and NaF in one dentifrice formulation or to combine use of MFP dentifrice with a NaF rinse.

Section: Williamsonmentioning

confidence: 99%

Section: Williamsonmentioning

confidence: 99%

Clinical Studies of Monofluorophosphate Dentifrices

DePaola¹

1983

“…As the plaque becomes acidic, calcium and phosphate are released at the expense of hydrogen ions and protect the enamel against demineralization by common ion effects [Dawes and Jenkins, 1962;Kleinberg et al, 1983]. Fluoride has been suggested as an agent to stimulate plaque mineralization [Pearce, 1981], There is clinical evidence for an additive cariesinhibitory effect of calcium glycerophosphate and fluoride [Naylor and Glass, 1979;Mainwaring and Naylor, 1983]. This effect is likely to be explained by increased mineralization of plaque [Duke et al, 1979] and increased uptake of fluoride by dental enamel [Chowet al, 1981;Mellberg and Chomicki, 1985], Similarly, calcium lactate and fluoride were found to have additive protective effects on caries develop ment in rats [van der Hoeven, 1985].…”

Section: Discussionmentioning

confidence: 99%

Effect of a Mouthrinse Containing Calcium Lactate on the Formation and Mineralization of Dental Plaque

Hoeven¹,

Schaeken²,

Creugers³

1989

In this study, a mouthrinse containing calcium lactate was tested for its effect on the accumulation of dental plaque and on the concentrations of calcium and phosphorus therein. Human volunteers rinsed four times per day with a calcium lactate (165 mmol/l) solution for 1 week. Plaque samples, collected 16 h after the last rinse, were analyzed chemically. Calcium lactate rinses had no effect on the plaque score, but resulted in approximately twofold increases of calcium and phosphorus in plaque. The incorporation of monofluorophosphate (5 mmol/l) into the rinsing solution failed to show any significant influence on calcium, phosphorus, and fluoride levels in plaque. Increased mineral deposition in the plaque may provide an explanation for the reduced caries development earlier observed in rats fed a diet containing calcium lactate.

“…These studies, amongst others, fi rmly established the anti-caries properties of CaGP. Subsequently, CaGP was included in a number of dentifrice formulations as a component of the anti-caries system, usually in conjunction with fl uoride as sodium monofl uorophosphate (SMFP), and caries clinical studies have been conducted to assess the anti-caries effi cacy of the system [Naylor and Glass, 1979;Mainwaring and Naylor, 1983].Several possible mechanisms for the anti-caries properties of CaGP have been investigated. These include elevation of plaque calcium and phosphate concentrations [Duke et al, 1979], plaque pH buffering [Bowen, 1972],…”

mentioning

confidence: 99%

Effect of Calcium Glycerophosphate on Demineralization in an in vitro Biofilm Model

Lynch

Cate

2006

The aim was to investigate the anti-caries properties of calcium glycerophosphate (CaGP) using an in vitro bacterial flow cell model. Four flow cells, inoculated from a chemostat containing a seven-organism bacterial consortium, were pulsed with sucrose twice daily, to provide an acidic challenge and pH-cycling conditions. Blocks of enamel and dentine were mounted in each flow cell. In a study on the effect of CaGP concentration, CaGP was pulsed into three of the flow cells, at the same time as the sucrose, to give concentrations of 0.10, 0.25 and 0.50%. Water was pulsed into the fourth flow cell with the sucrose. Microradiography revealed a significant dose response of decreasing demineralization as CaGP concentration increased. Reductions at 0.25 and 0.5% were significant when compared to the control. A second study investigated the effect of timing of CaGP pulsing, relative to sucrose, on enamel and dentine demineralization. CaGP (flow cell concentration 0.2%), was pulsed 1 h before, during or 1 h after the sucrose pulse; a water control was employed. In enamel, pulsing CaGP before the sucrose reduced demineralization significantly compared to concurrent pulsing, which in turn gave a significant reduction compared to pulsing after sucrose, which did not reduce demineralization significantly compared to the water control. In dentine, CaGP reduced demineralization significantly only when pulsed before the sucrose. The findings suggest that in vivo, the anti-caries potential of CaGP may be greater if it is applied before a cariogenic challenge.