A 3‐year oral health dose‐response study of sodium monofluoro‐phosphate dentifrices with and without zinc citrate: anti‐caries results

Stephen, K.W.; Creanor, S.L.; Russell, J. I.; Burchell, C.K.; Huntington, E.; Downie, Charles F. A.

doi:10.1111/j.1600-0528.1988.tb00574.x

Cited by 111 publications

(79 citation statements)

References 11 publications

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“…Some clinical studies have shown that with 1000 to 2500 ppm F toothpaste an increase of 6% is obtained in dental caries protection for each 500 ppm (23,35).…”

Section: Discussionmentioning

confidence: 99%

Effect of 1000 or More ppm Relative to 440 to 550 ppm Fluoride Toothpaste - A Systematic Review

Cadavid¹,

Hernández²,

Lince³

2012

Contemporary Approach to Dental Caries

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“…Some clinical studies have shown that with 1000 to 2500 ppm F toothpaste an increase of 6% is obtained in dental caries protection for each 500 ppm (23,35).…”

Section: Discussionmentioning

confidence: 99%

Effect of 1000 or More ppm Relative to 440 to 550 ppm Fluoride Toothpaste - A Systematic Review

Cadavid¹,

Hernández²,

Lince³

2012

Contemporary Approach to Dental Caries

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“…Data from in vitro and in situ studies support this proposition [19,20]. Overall, the effect of zinc on caries development is proposed to be neutral [6,21].…”

Section: A C C E P T E Dmentioning

confidence: 99%

Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model

Parkinson¹,

Burnett²,

Creeth³

et al. 2018

Journal of Dentistry

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Objectives: To compare and explore the dose-response of phytate-containing 1150 ppm fluoride toothpastes on model caries lesions and to determine the impact of zinc ions.Methods: This was a single-centre, randomised, blinded (examiner/laboratory analyst), sixtreatment, four-period crossover, in situ study in adults with a removable bilateral maxillary partial denture. Study treatments were toothpastes containing: 0.425% phytate/F; 0.85% phytate/F; 0.85% phytate/Zn/F; F-only; Zn/F and a 0% F placebo. Where present, F was 1150 ppm as NaF; Zn was 0.3% Clinical significance: Toothpastes may contain therapeutic or cosmetic agents that could interfere with fluoride's caries prevention efficacy. The present in situ caries study has demonstrated that phytate, added to provide enhanced extrinsic stain removal/prevention, and zinc, added to inhibit malodour, do not impair fluoride efficacy.

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“…Clinical trials indicate that within the range 1,000 to 2,500 ppm F an increase in fluoride of around 500 ppm results in an additional 6% reduction in dental caries. 17,18 In the UK 41% of the parents of young children aged 1fi to 2fi years claim to use a toothpaste containing less than 600 ppm F. 10 Toothpastes containing higher concentrations of fluoride confer greater protection against dental caries but increase the risk of fluorosis. In contrast, low fluoride toothpastes provide less protection against dental caries but reduce the risk of fluorosis.…”

Section: Discussionmentioning

confidence: 99%

Fluoride ingestion from toothpaste by young children

Bentley¹,

Ellwood²,

Davies³

1999

Br Dent J

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RESEARCH oral hygieneThe aim of this study was to investigate the reported and observed brushing habits of children aged 30 months and determine the amount of fluoride retained and ingested after brushing with a fluoride toothpaste. MethodIn 1997, 50 children, aged 30 months, who were participating in a community dental health programme, were randomly selected from three districts in the North West Region of England. The homes were visited and parents were first asked about their child's brushing habits. Each child was weighed clothed, but without shoes, on household scales. Parents were then provided with a new, childsize brush (Colgate My First) and a weighed tube of toothpaste and asked to brush their child's teeth in the usual manner. Half the children used a children's toothpaste containing 400 ppm F (Colgate 0-6 Gel) and half used a family toothpaste containing 1,450 ppm F (Colgate Great Regular Flavour). The orifice of both tubes was 8 mm but that of Colgate 0-6 Gel had a star-shaped nozzle. The weight of toothpaste applied per brushing was measured and the method of brushing was observed and recorded.In order to determine the amount of toothpaste and fluoride retained in the mouth after brushing, the amount of toothpaste retained on the brush and collected in rinsing fluids was measured. Care was taken to ensure that toothpaste was not retained on the lips, face and hands of subjects. If this occurred the data for the subject were to be discarded. All waste toothpaste and fluids were stored and placed in a secure container together with the toothbrush. The amount of fluoride from toothpaste remaining on the toothbrush and in the waste fluids was then determined by gas chromatography. 11 The difference between the amount of toothpaste applied to the brush and that recovered after brushing was estimated to be the amount of toothpaste ingested. Results Reported and observed toothbrushing behaviourWhen interviewed, 48 mothers reported that they always put the toothpaste on the child's brush and only two said that their child usually did so. However, five children were observed to dispense their own toothpaste.Thirty-four mothers reported that toothbrushing usually involved both the parent and child, 12 stated that they always brushed their child's teeth and four said that their child brushed their own teeth. However, it was observed that in 21 instances toothbrushing involved both parent and child, 17 parents brushed their child's teeth and 12 children brushed without help.The mothers of 17 children reported that their child spat out toothpaste, although only five were observed to do so. When observed 38 children washed the brush under a running tap and then sucked and swallowed the water from the brush. Although 15 children were reported to use a cup of water, only three did so when observed and these children then spat the water out. Spitting ability was reported by the parents to be a recent phenomenon. TwentyObjective To investigate the reported and observed brushing habits of young children and their in...

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A 3‐year oral health dose‐response study of sodium monofluoro‐phosphate dentifrices with and without zinc citrate: anti‐caries results

Cited by 111 publications

References 11 publications

Effect of 1000 or More ppm Relative to 440 to 550 ppm Fluoride Toothpaste - A Systematic Review

Effect of 1000 or More ppm Relative to 440 to 550 ppm Fluoride Toothpaste - A Systematic Review

Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model

Fluoride ingestion from toothpaste by young children

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