A 65-Kilobase Pathogenicity Island Is Unique to Philadelphia-1 Strains of
            <i>Legionella pneumophila</i>

Brassinga, Ann Karen C.; Hiltz, Margot; Sisson, Gary; Morash, Michael G.; Hill, Nathan R.; Garduño, Elizabeth; Edelstein, Paul H.; Garduño, Rafael A.; Hoffman, Paul S.

doi:10.1128/jb.185.15.4630-4637.2003

Cited by 54 publications

(50 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high frequency of L. pneumophila serogroup 1 isolation from clinical samples, as previously observed (5,16), is not therefore linked to environmental predominance but may be due to higher infectivity or more efficient intracellular growth (1,2). The low prevalence of non-pneumophila species among clinical isolates relative to their environmental abundance suggests that these species are less pathogenic than L. pneumophila, in keeping with the observation that most confirmed infections involving non-pneumophila species occur in immunosuppressed patients (10).…”

mentioning

confidence: 49%

Clinical and Environmental Distributions of Legionella Strains in France Are Different

et al. 2004

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 49%

Clinical and Environmental Distributions of Legionella Strains in France Are Different

et al. 2004

View full text Add to dashboard Cite

show abstract

“…The region carrying the Lvh T4ASS Chien et al 2004), the 65-kb pathogenicity island (PAI) (Brassinga et al 2003), and a 100-kb region containing several genes encoding efflux transporters for heavy metals and other toxic substances (Chien et al 2004). As shown in Figure 1, these genetic elements were distributed heterogeneously among the investigated strains, indicating that they are mobile and can be exchanged by horizontal gene transfer.…”

Section: Horizontal Gene Transfer Of Mobile Genetic Elements Among Thmentioning

confidence: 98%

Multigenome analysis identifies a worldwide distributed epidemic Legionella pneumophila clone that emerged within a highly diverse species

Cazalet¹,

Jarraud²,

Ghavi-Helm³

et al. 2008

Genome Res.

157

174

View full text Add to dashboard Cite

Genomics can provide the basis for understanding the evolution of emerging, lethal human pathogens such as Legionella pneumophila, the causative agent of Legionnaires’ disease. This bacterium replicates within amoebae and persists in the environment as a free-living microbe. Among the many Legionella species described, L. pneumophila is associated with 90% of human disease and within the 15 serogroups (Sg), L. pneumophila Sg1 causes over 84% of Legionnaires’ disease worldwide. Why L. pneumophila Sg1 is so predominant is unknown. Here, we report the first comprehensive screen of the gene content of 217 L. pneumophila and 32 non-L. pneumophila strains isolated from humans and the environment using a Legionella DNA-array. Strikingly, we uncovered a high conservation of virulence- and eukaryotic-like genes, indicating strong environmental selection pressures for their preservation. No specific hybridization profile differentiated clinical and environmental strains or strains of different serogroups. Surprisingly, the gene cluster coding the determinants of the core and the O side-chain synthesis of the lipopolysaccaride (LPS cluster) determining Sg1 was present in diverse genomic backgrounds, strongly implicating the LPS of Sg1 itself as a principal cause of the high prevalence of Sg1 strains in human disease and suggesting that the LPS cluster can be transferred horizontally. Genomic analysis also revealed that L. pneumophila is a genetically diverse species, in part due to horizontal gene transfer of mobile genetic elements among L. pneumophila strains, but also between different Legionella species. However, the genomic background also plays a role in disease causation as demonstrated by the identification of a globally distributed epidemic strain exhibiting the genotype of the sequenced L. pneumophila strain Paris.

show abstract

“…The 130-kb insertion is flanked by a tRNA gene and encodes a putative integrase, suggesting a structure similar to the pathogenicity islands of enterobacteria. It contains genes encoding an ATP synthase and chemiosmotic efflux systems (cebABC, cecABC), the genes cadA1, ctpA, copA1 and copA2, which encode ATP-dependent efflux pumps and have been shown to be induced in macrophages 35 , and the prpA-lvrABC gene cluster, which is present in a 65-kb pathogenicity island in strain Philadelphia 36 . …”

Section: Physiological Adaptation and Gene Regulationmentioning

confidence: 99%

Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity

et al. 2004

View full text Add to dashboard Cite

A 65-Kilobase Pathogenicity Island Is Unique to Philadelphia-1 Strains of Legionella pneumophila

Cited by 54 publications

References 39 publications

Clinical and Environmental Distributions of Legionella Strains in France Are Different

Clinical and Environmental Distributions of Legionella Strains in France Are Different

Multigenome analysis identifies a worldwide distributed epidemic Legionella pneumophila clone that emerged within a highly diverse species

Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity

Contact Info

Product

Resources

About