A biomaterials approach to Schwann cell development in neural tissue engineering

Lotfi, Leila; Khakbiz, Mehrdad; Moghaddam, Mehrdad Moosazadeh; Bonakdar, Shahin

doi:10.1002/jbm.a.36749

Cited by 32 publications

(37 citation statements)

References 130 publications

(231 reference statements)

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“…Besides, SCs exhibit durotaxis and are able to transduce mechanical signals via multiple molecular mechanisms [2]. In recent years, researchers have explored the use of biomaterials with altered chemical, topographical and mechanical characteristics to more closely mimic the properties of peripheral nerve tissues to direct cell fate and promote regeneration [143].…”

Section: Soluble Mitogens Are Axon-mimetics That Maintain the Sc Phenmentioning

confidence: 99%

Schwann Cell Cultures: Biology, Technology and Therapeutics

Monje

2020

Cells

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Schwann cell (SC) cultures from experimental animals and human donors can be prepared using nearly any type of nerve at any stage of maturation to render stage- and patient-specific populations. Methods to isolate, purify, expand in number, and differentiate SCs from adult, postnatal and embryonic sources are efficient and reproducible as these have resulted from accumulated refinements introduced over many decades of work. Albeit some exceptions, SCs can be passaged extensively while maintaining their normal proliferation and differentiation controls. Due to their lineage commitment and strong resistance to tumorigenic transformation, SCs are safe for use in therapeutic approaches in the peripheral and central nervous systems. This review summarizes the evolution of work that led to the robust technologies used today in SC culturing along with the main features of the primary and expanded SCs that make them irreplaceable models to understand SC biology in health and disease. Traditional and emerging approaches in SC culture are discussed in light of their prospective applications. Lastly, some basic assumptions in vitro SC models are identified in an attempt to uncover the combined value of old and new trends in culture protocols and the cellular products that are derived.

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Section: Soluble Mitogens Are Axon-mimetics That Maintain the Sc Phenmentioning

confidence: 99%

Schwann Cell Cultures: Biology, Technology and Therapeutics

Monje

2020

Cells

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“…Properties such as biocompatibility, non-immunogenic, allowing the diffusion of matter (nutrients, oxygen etc. ), and promoting cell migration and proliferation are provided to the scaffold by biomaterials [129,130]. dECM, scaffolds, and hydrogels made from natural and synthetic polymers are used for CNS regeneration [130][131][132][133].…”

Section: Biomaterials Used For Neural Damagesmentioning

confidence: 99%

“…For example, acellular scaffolds facilitate axonal regeneration, accelerating functional recovery [134]. It also offers the closest 3D structure to the natural ECM structure [130]. Collagen, hyaluronic acid (HA), chitosan, gelatin, agarose, alginate, and fibrin are the most commonly used natural polymers [130][131][132].…”

Section: Biomaterials Used For Neural Damagesmentioning

confidence: 99%

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Combating COVID-19 with tissue engineering: a review

et al. 2020

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The ongoing COVID-19 pandemic triggered by SARS-CoV-2 emerged from Wuhan, China, firstly in December 2019, as well spread to almost all around the world rapidly. The main reason why this disease spreads so many people in a short time is that the virus could be transmitted from an infected person to another by infected droplets. The new emergence of diseases usually may affect multiple organs; moreover, this disease is such an example. Numerous reported studies focus on acute or chronic organ damage caused by the virus. At this point, tissue engineering (TE) strategies can be used to treat the damages with its interdisciplinary approaches. Tissue engineers could design drug delivery systems, scaffolds, and especially biomaterials for the damaged tissue and organs. In this review, brief information about SARS-CoV-2, COVID-19, and epidemiology of the disease will be given at first. After that, the symptoms, the tissue damages in specific organs, and cytokine effect caused by COVID-19 will be described in detail. Finally, it will be attempted to summarize and suggest the appropriate treatments with suitable biomaterials for the damages via TE approaches. The aim of this review is to serve as a summary of currently available tissue damage treatments after COVID-19.

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“…These fabricated geometrical cues are designed to resemble the geometrical cues that cells are subjected to in vivo, in the form of both native tissue and biomimetic scaffolds, which are known to influence various cellular responses. For example, neuron growth is strongly guided by the directions of scaffold fibers, leading to various approaches to induce nerve repair by tuning the properties of biomaterials and scaffolds [41,42]. Another example is in the case of (micro)vascular tissue engineering, where multiple cell types need to organize in different configurations (e.g., endothelial cells in a concave tubular construct, wrapped around by pericytes) to ensure function within the microvasculature [43,44].…”

Section: Introductionmentioning

confidence: 99%

Cellular Geometry Sensing at Different Length Scales and its Implications for Scaffold Design

2020

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Geometrical cues provided by the intrinsic architecture of tissues and implanted biomaterials have a high relevance in controlling cellular behavior. Knowledge of how cells sense and subsequently respond to complex geometrical cues of various sizes and origins is needed to understand the role of the architecture of the extracellular environment as a cell-instructive parameter. This is of particular interest in the field of tissue engineering, where the success of scaffold-guided tissue regeneration largely depends on the formation of new tissue in a native-like organization in order to ensure proper tissue function. A well-considered internal scaffold design (i.e., the inner architecture of the porous structure) can largely contribute to the desired cell and tissue organization. Advances in scaffold production techniques for tissue engineering purposes in the last years have provided the possibility to accurately create scaffolds with defined macroscale external and microscale internal architectures. Using the knowledge of how cells sense geometrical cues of different size ranges can drive the rational design of scaffolds that control cellular and tissue architecture. This concise review addresses the recently gained knowledge of the sensory mechanisms of cells towards geometrical cues of different sizes (from the nanometer to millimeter scale) and points out how this insight can contribute to informed architectural scaffold designs.

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A biomaterials approach to Schwann cell development in neural tissue engineering

Cited by 32 publications

References 130 publications

Schwann Cell Cultures: Biology, Technology and Therapeutics

Schwann Cell Cultures: Biology, Technology and Therapeutics

Combating COVID-19 with tissue engineering: a review

Cellular Geometry Sensing at Different Length Scales and its Implications for Scaffold Design

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