A Biomimetic Drug Delivery System by Integrating Grapefruit Extracellular Vesicles and Doxorubicin-Loaded Heparin-Based Nanoparticles for Glioma Therapy

Niu, Wenbo; Xiao, Qian; Wang, Xuejiao; Zhu, Junqiao; Li, Jin‐Heng; Liang, Xiaomei; Peng, Yingming; Wu, Chentian; Lu, Ruojing; Pan, Yao; Luo, Jiamao; Zhong, Xinxian; He, Haoqi; Rong, Zhili; Fan, Jun‐Bing; Wang, Ying

doi:10.1021/acs.nanolett.0c04753

Cited by 199 publications

(145 citation statements)

References 37 publications

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“…EVs themselves have proved to be good drug carriers, so combining them with nanoparticles would only increase the efficacy for a drug delivery system. In 2021, Niu and co-authors [ 93 ] developed a nanocomplex based on heparin-based nanoparticles, loaded with doxorubicin, and then patched with extracellular vesicles, in order to improve doxorubicin’s efficacy on glioma cells. The complex managed to surpass the blood–brain barrier and accumulated in a high amount at the tumor site, thus offering another potential use for extracellular vesicles.…”

Section: Nanoparticles and Extracellular Vesiclesmentioning

confidence: 99%

Tetraspanins: Physiology, Colorectal Cancer Development, and Nanomediated Applications

Ţîţu

Grapa

Mocan

et al. 2021

Cancers

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Tetraspanins are transmembrane proteins expressed in a multitude of cells throughout the organism. They contribute to many processes that surround cell–cell interactions and are associated with the progress of some diseases, including cancer. Their crucial role in cell physiology is often understated. Furthermore, recent studies have shown their great potential in being used as targeting molecules. Data have suggested the potential of tetraspanins as a targeting vector for nanomediated distribution and delivery for colorectal cancer applications. Our aim is to provide a review on the important part that tetraspanins play in the human organism and highlight their potential use for drug delivery systems using nanotechnology.

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Section: Nanoparticles and Extracellular Vesiclesmentioning

confidence: 99%

Tetraspanins: Physiology, Colorectal Cancer Development, and Nanomediated Applications

Ţîţu

Grapa

Mocan

et al. 2021

Cancers

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“…Table 2 summarizes different examples of NPs coated with EVs, their coating mechanisms, and the unique features of this strategy for drug delivery applications. [105,106,119,137,[146][147][148][149][150][151][152][153][154][155]…”

Section: Evs-mesoporous Silica Npsmentioning

confidence: 99%

Extracellular Vesicle Nanoarchitectonics for Novel Drug Delivery Applications

Sharma

Masud

Kaneti

et al. 2021

Small

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Extracellular vesicles (EVs) can transfer intercellular messages in various (patho)physiological processes and transport biomolecules to recipient cells. EVs possess the capacity to evade the immune system and remain stable over long periods, identifying them as natural carriers for drugs and biologics. However, the challenges associated with EVs isolation, heterogeneity, coexistence with homologous biomolecules, and lack of site‐specific delivery, have impeded their potential. In recent years, the amalgamation of EVs with rationally engineered nanostructures has been proposed for achieving effective drug loading and site‐specific delivery. With the advancement of nanotechnology and nanoarchitectonics, different nanostructures with tunable size, shapes, and surface properties can be integrated with EVs for drug loading, target binding, efficient delivery, and therapeutics. Such integration may enable improved cellular targeting and the protection of encapsulated drugs for enhanced and specific delivery to target cells. This review summarizes the recent development of nanostructure amalgamated EVs for drug delivery, therapeutics, and real‐time monitoring of disease progression. With a specific focus on the exosomal cargo, diverse drug delivery system, and biomimetic nanostructures based on EVs for selective drug delivery, this review also chronicles the needs and challenges of EV‐based biomimetic nanostructures and provides a future outlook on the strategies posed.

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“…Exosomes from human hepatocarcinoma Doxorubicin-loaded biomimetic porous silicon NPs Cytotoxicity against bulk cancer cells and cancer stem cells [300] Grapefruit EVs Doxorubicin-loaded heparin-based NPs Glioma treatment [301] Exosomes from melanoma cells…”

Section: Parental Cell Cargo Application Referencementioning

confidence: 99%

Lipid-Based Nanovesicular Drug Delivery Systems

et al. 2021

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In designing a new drug, considering the preferred route of administration, various requirements must be fulfilled. Active molecules pharmacokinetics should be reliable with a valuable drug profile as well as well-tolerated. Over the past 20 years, nanotechnologies have provided alternative and complementary solutions to those of an exclusively pharmaceutical chemical nature since scientists and clinicians invested in the optimization of materials and methods capable of regulating effective drug delivery at the nanometer scale. Among the many drug delivery carriers, lipid nano vesicular ones successfully support clinical candidates approaching such problems as insolubility, biodegradation, and difficulty in overcoming the skin and biological barriers such as the blood–brain one. In this review, the authors discussed the structure, the biochemical composition, and the drug delivery applications of lipid nanovesicular carriers, namely, niosomes, proniosomes, ethosomes, transferosomes, pharmacosomes, ufasomes, phytosomes, catanionic vesicles, and extracellular vesicles.

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A Biomimetic Drug Delivery System by Integrating Grapefruit Extracellular Vesicles and Doxorubicin-Loaded Heparin-Based Nanoparticles for Glioma Therapy

Cited by 199 publications

References 37 publications

Tetraspanins: Physiology, Colorectal Cancer Development, and Nanomediated Applications

Tetraspanins: Physiology, Colorectal Cancer Development, and Nanomediated Applications

Extracellular Vesicle Nanoarchitectonics for Novel Drug Delivery Applications

Lipid-Based Nanovesicular Drug Delivery Systems

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