A biotin-conjugated photo-activated CO-releasing molecule (biotinCORM): efficient CO-release from an avidin–biotinCORM protein adduct

Ward, Jonathan S.; Palo, Alice De; Aucott, Benjamin J.; Moir, James; Lynam, Jason M.; Fairlamb, Ian J. S.

doi:10.1039/c9dt03429c

Cited by 6 publications

(2 citation statements)

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“…Fairlamb, Lynam, and co-workers synthesized a series of biotin-conjugated Mn I -based photo-CORMs 255 (R = biotin; Table 16) that release CO upon irradiation at 400 nm and bind efficiently to avidin. 1174 Fluorescent dansylimidazole-substituted complex 256a (Table 16) released CO upon irradiation with visible light. 1175 Its analog 256b exhibited strong green luminescence that could be visualized in vitro.…”

Section: Photorelease Of Gasotransmittersmentioning

confidence: 99%

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Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

et al. 2020

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Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable) protecting groups (PPGs), also known as caged or photocaged compounds, are used to enable non-invasive spatiotemporal photochemical control over the release of species of interest. Recent years have seen the development of PPGs activatable by biologically and chemically benign visible and near-infrared (NIR) light. These long-wavelength-absorbing moieties expand the applicability of this powerful method and its accessibility to non-specialist users. This review comprehensively covers organic and transition metal-containing photoactivatable compounds (complexes) that absorb in the visible- and NIR-range to release various leaving groups and gasotransmitters (carbon monoxide, nitric oxide, and hydrogen sulfide). The text also covers visible- and NIR-light-induced photosensitized release using molecular sensitizers, quantum dots, and upconversion and second-harmonic nanoparticles, as well as release via photodynamic (photooxygenation by singlet oxygen) and photothermal effects. Release from photoactivatable polymers, micelles, vesicles, and photoswitches, along with the related emerging field of photopharmacology, is discussed at the end of the review.

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Section: Photorelease Of Gasotransmittersmentioning

confidence: 99%

“…As a result, the photoCORMs become anionic and are trapped inside the cells. Fairlamb, Lynam, and co-workers synthesized a series of biotin-conjugated Mn I -based photoCORMs 255 (R = biotin; Table ) that release CO upon irradiation at 400 nm and bind efficiently to avidin …”

Section: Photorelease Of Gasotransmittersmentioning

confidence: 99%