performance limitations of the siliconbased flash memory, such as slow switching speed and poor endurance. [1−4] However, memristors based on conventional bulk metal oxides suffer from high off-current, low reliability, and the use of a relatively thick oxide layer. [5−8] Low dimensional semiconductors have been considered as potential building blocks for a range of novel electronic and optoelectronic applications due to their unique properties, including excellent electrical conductivity, a high on/off current ratio, good flexibility, and strong light-matter interaction. [9−16] In particular, memristors based on these materials have emerged as an ideal platform for logic gates, imaging sensors, and artificial synapses for neuromorphic learning. [16−19] Despite their excellent performances, two-terminal optoelectronic memristors can respond to only one input signal from voltage bias, which restricts their applications for multilevel resistive switching memories and complex learning networks. [20] Tremendous efforts have been made to achieve both memristive switching of the memristor and gate tunability of fieldeffect transistors, the so-called memtransistor, to provide an additional degree of freedom to control bistable resistance states. [21−24] Most popular technical approaches are associated with the manipulation of defects and grain boundaries in resistive switching materials. As a good example, resistance states in MoS 2 -based memtransistors are controlled via electrically manipulating the migration of defects or sulfur vacancies. [21,22] However, the operating voltage is remarkably high (from 40 to 80 V), and the switching ratio is relatively small (10 2 -10 4 ). Moreover, repeated generation and manipulation of defects can deteriorate device performance and reliability. Another attempt to achieve memtransistors based on halide perovskites is in progress and has to address some issues such as their low on-off ratio, instability, and toxicity. [25] Thus, it would be beneficial and advantageous to develop a predictable device design-based memtransistor structure that is material-independent, scalable, and conducive to increasing the integration of the circuit for neuromorphic computing. [26,27] Van der Waals (vdW) heterostructures based on 2D materials including graphene and TMDs are highly desirable for The exploration of memtransistors as a combination of a memristor and a transistor has recently attracted intensive attention because it offers a promising candidate for next-generation multilevel nonvolatile memories and synaptic devices. However, the present state-of-the-art memtransistors, which are based on a single material, such as MoS 2 or perovskite, exhibit a relatively low switching ratio, require extremely high electric fields to modulate bistable resistance states and do not perform multifunctional operations. Here, the realization of an electrically and optically controllable p-n junction memtransistor using an Al 2 O 3 encapsulated 2D Te/ReS 2 van der Waals heterostructure is reported. Th...