A Capacitive MEMS Viscometric Sensor for Affinity Detection of Glucose

Huang, Xian; Li, Siqi; Schultz, Jerome S.; Wang, Qin; Lin, Qiao

doi:10.1109/jmems.2009.2034869

Cited by 30 publications

(8 citation statements)

References 23 publications

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“…However, with a high concentration of boronic acid moieties (which was the case for our hydrogel), boronic acid can bind with glucose at a 2:1 ratio 35–37 . We exploited this property in previous work and developed solution-phase, viscometrically based affinity microsensors 37, 38 . In this work, we postulate that the existence of 2:1 binding between glucose and boronic acid moieties played a major role in the microsensor response, by causing additional crosslinking of the hydrogel that could lead to the augmentation of elastic resistance to electric field-induced dipole reorientation.…”

Section: Resultsmentioning

confidence: 99%

A hydrogel-based glucose affinity microsensor

Shang

Yan

Zhang

et al. 2016

Sensors and Actuators B: Chemical

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We present a hydrogel-based affinity microsensor for continuous glucose measurements. The microsensor is based on microelectromechanical systems (MEMS) technology, and incorporates a synthetic hydrogel that is attached to the device surface via in situ polymerization. Glucose molecules that diffuses into and out of the device binds reversibly with boronic acid groups in the hydrogel via affinity binding, and causes changes in the dielectric properties of the hydrogel, which can be measured using a MEMS capacitive transducer to determine the glucose concentration. The use of the in situ polymerized hydrogel eliminates mechanical moving parts found in other types of affinity microsensors, as well as mechanical barriers such as semipermeable membranes that are otherwise required to hold the glucose-sensitive material. This facilitates the miniaturization and robust operation of the microsensor, and can potentially improve the tolerance of the device, when implanted subcutaneously, to biofouling. Experimental results demonstrate that in a glucose concentration range of 0–500 mg/dL and with a resolution of 0.35 mg/dL or better, the microsensor exhibits a repeatable and reversible response, and can potentially be useful for continuous glucose monitoring in diabetes care.

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Section: Resultsmentioning

confidence: 99%

A hydrogel-based glucose affinity microsensor

Shang

Yan

Zhang

et al. 2016

Sensors and Actuators B: Chemical

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“…The capacitive biosensors measure the changes in dielectric properties at the interface between the electrode and electrolyte when the analyte interacts with the immobilized receptors on the isolated dielectric layer [ 12 ]. The use of capacitive biosensors in glucose detection has been reported by several researchers [ 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Glucose Sensing Using Capacitive Biosensor Based on Polyvinylidene Fluoride Thin Film

2018

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A polyvinylidene fluoride (PVDF) film-based capacitive biosensor was developed for glucose sensing. This device consists of a PVDF film sandwiched between two electrodes. A capacitive biosensor measures the dielectric properties of the dielectric layers at the interface between the electrolyte and the electrode. A glucose oxidase (GOx) enzyme was immobilized onto the electrode to oxidize glucose. In practice, the biochemical reaction of glucose with the GOx enzyme generates free electron carriers. Consequently, the potential difference between the electrodes is increased, resulting in a measurable voltage output of the biosensor. The device was tested for various glucose concentrations in the range of 0.013 to 5.85 M, and various GOx enzyme concentrations between 4882.8 and 2.5 million units/L. We found that the sensor output increased with increasing glucose concentration up to 5.85 M. These results indicate that the PVDF film-based capacitive biosensors can be properly applied to glucose sensing and provide opportunities for the low-cost fabrication of glucose-based biosensors based on PVDF materials.

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“…The MEMS differential affinity glucose sensor is based on a pair of surface-machined freestanding diaphragms that vibrate under an external ac magnetic field [26] and are each situated inside a microchamber (figure 1). One chamber (the sensing chamber) is filled with a solution of a glucose-affinity polymer (the sensing solution), while the other chamber (the reference chamber) contains a solution of a polymer that does not bind with glucose (the reference solution).…”

Section: Principle and Designmentioning

confidence: 99%

“…Affinity glucose sensors based on microelectromechanical systems (MEMS) technology hold the potential for glucose sensing, enabling miniaturization that would lead to improved measurement time response and minimized invasiveness. MEMS sensors have been used to measure glucoseinduced changes in fluorescence intensity [23,24], viscosity [25][26][27], hydrogen swelling [28], conductivity [29] and permittivity [30]. In addition, MEMS technology has also demonstrated interstitial fluid (ISF) sampling devices, which, with potential application to affinity glucose detection, employ microdialysis [31,32], microneedles [33], sohophoresis [34] and microablation [35].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, MEMS technology has also demonstrated interstitial fluid (ISF) sampling devices, which, with potential application to affinity glucose detection, employ microdialysis [31,32], microneedles [33], sohophoresis [34] and microablation [35]. We have previously reported affinity glucose sensors based on a vibrational cantilever [25] or diaphragm [26]. These devices each contain a single glucosedetection module that measures the glucose-induced viscosity change in a solution of a glucose-sensitive polymer, and have demonstrated the feasibility of MEMS-based affinity sensors for CGM.…”

Section: Introductionmentioning

confidence: 99%

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A MEMS differential viscometric sensor for affinity glucose detection in continuous glucose monitoring

Huang¹,

Li²,

Davis³

et al. 2013

J. Micromech. Microeng.

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Micromachined viscometric affinity glucose sensors have been previously demonstrated using vibrational cantilever and diaphragm. These devices featured a single glucose detection module that determines glucose concentrations through viscosity changes of glucose-sensitive polymer solutions. However, fluctuations in temperature and other environmental parameters might potentially affect the stability and reliability of these devices, creating complexity in their applications in subcutaneously implanted continuous glucose monitoring (CGM). To address these issues, we present a MEMS differential sensor that can effectively reject environmental disturbances while allowing accurate glucose detection. The sensor consists of two magnetically driven vibrating diaphragms situated inside microchambers filled with a boronic-acid based glucose-sensing solution and a reference solution insensitive to glucose. Glucose concentrations can be accurately determined by characteristics of the diaphragm vibration through differential capacitive detection. Our in-vitro and preliminary in-vivo experimental data demonstrate the potential of this sensor for highly stable subcutaneous CGM applications.

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A Capacitive MEMS Viscometric Sensor for Affinity Detection of Glucose

Cited by 30 publications

References 23 publications

A hydrogel-based glucose affinity microsensor

A hydrogel-based glucose affinity microsensor

Glucose Sensing Using Capacitive Biosensor Based on Polyvinylidene Fluoride Thin Film

A MEMS differential viscometric sensor for affinity glucose detection in continuous glucose monitoring

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