A carbon nanofiber based biosensor for simultaneous detection of dopamine and serotonin in the presence of ascorbicacid

Abstract

A biosensor based on an array of vertically aligned carbon nanofibers (CNFs) grown by plasma enhanced chemical vapor deposition is found to be effective for the simultaneous detection of dopamine (DA) and serotonin (5-HT) in the presence of excess ascorbic acid (AA). The CNF electrode outperforms the conventional glassy carbon electrode (GCE) for both selectivity and sensitivity. Using differential pulse voltammetry (DPV), three distinct peaks are seen for the CNF electrode at 0.13 V, 0.45 V, and 0.70 V for the ternary mixture of AA, DA, and 5-HT. In contrast, the analytes are indistinguishable in a mixture using a GCE. For the CNF electrode, the detection limits are 50 nM for DA and 250 nM for 5-HT.

Integrated Carbon Nanostructures for Detection of Neurotransmitters

“…There is a significant difference with published results in the literature when the sensitivity of plain CNF electrode towards DA has been found to be as low as 50 nM [15]. The reasons for the relatively poor sensitivity of the hybrid material here are not clear at present.…”

“…The promising results on CNF sensitivity and selectivity towards different neurotransmitters published earlier [15] suggest that the integration of CNFs on ta-C surfaces may be as advantageous as it was observed for ta-C + CNT hybrids. To study such a plausible option, we synthesized novel hybrids of ta-C and CNF using a very similar approach to that for the CNT hybrid structures.…”

Nitrogen-doped carbon nanospheres derived from cocoon silk as metal-free electrocatalyst for glucose sensing

“…The performance was rather comparable to leading literature results, which are summarized in Table 4. This finding demonstrates that the present electrode has satisfied detection limit, linear range and sensitivity 12 compared to the earlier reports. For example, it displays better sensitivity than the glucose biosensor based on MWCNT [42,43] and gold nanoparticles decorated MWCNT [41], and the linear range for the determination of glucose is even wider than CuNP-SWCNT-Nafion/GCE sensing platform [44].…”

“…The oxidation treatment of carbon nanotubes (CNTs), carbon nanofiber (CNF) and graphene using acid can produce a range of oxygen-rich groups on their surface, which lead to better dispersion and wettability of the materials. In addition, the edge sites produced from the acid treatment accelerate the electron transfer of electroactive analytes, which is the key in preparing effective electrodes [10][11][12]. Till now, a series of modified electrodes based on CNF [13], CNTs [14] and reduced graphene oxide [15] have been developed for detecting dissolved oxygen.…”

Electrochemical nanoprobes for the chemical detection of neurotransmitters

“…The Koehne lab has developed such arrays 85–89 (Fig. 5a and b) using plasma enhanced chemical vapor deposition to grow vertical carbon nanofibers on silicon substrates.…”