A case-control study of diet and social factors in cancer of the esophagus in transkei

Sammon, Alastair M.

doi:10.1002/1097-0142(19920215)69:4<860::aid-cncr2820690404>3.0.co;2-y

Cited by 32 publications

(29 citation statements)

References 10 publications

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“…There are other potential explanations for the high incidence of esophageal squamous cell cancer in western Kenya. These include the presence of fungal toxins in stored grain, 29 diet, 30 micronutrient deficiencies, 31 exposure to smoke from cooking fires inside homes and other toxic and genetic factors. Traditional risk factors such as cigarette smoke and alcohol may play a role in pathogenesis as well, but are unlikely to explain the high incidence of disease in this region, especially among women.…”

Section: Discussionmentioning

confidence: 99%

Absence of human papillomavirus in esophageal carcinomas from southwestern Kenya

White

Mungatana

Mutuma

et al. 2005

Diseases of the Esophagus

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Esophageal squamous cell cancer is highly prevalent in south-western Kenya. The role of human papillomavirus (HPV) in esophageal cancers from this region was evaluated. Biopsies of 29 esophageal squamous cell cancers were assayed for HPV DNA sequences by reverse line blot polymerase chain reaction, using 27 HPV type-specific probes. Viral sequences were found in none of the specimens. These results suggest the HPV is unlikely to be an etiologic factor for esophageal squamous cell cancers in this region.

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Section: Discussionmentioning

confidence: 99%

Absence of human papillomavirus in esophageal carcinomas from southwestern Kenya

White

Mungatana

Mutuma

et al. 2005

Diseases of the Esophagus

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“…the finding of a predominant role for tobacco smoking has been observed in several hospital-based case-control studies from South Africa. The earliest (Bradshaw and Schonland, 1969) (Sammon. 1992).…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with oesophageal cancer in Bulawayo, Zimbabwe

Vizcaino

Parkin²,

Skinner³

1995

Br J Cancer

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SununrThis report presents information on n'sk factors for oesophageal cancer in Bulawayo. Zimbabwe. The data analysed were from the Cancer Registry of Bulawayo for the years . when all registered patients were interviewed using a standard questionnaire. The age-standardised incidence rates in the urban population of Bulawayo in the first 10 year period were 58.6 per 100 000 in men and 8.1 in women. The distribution of risk factors was assessed in 881 oesophageal cancer cases (826 male. 55 female) and a control group comprising other non-tobacco-and non-alcohol-related cancer (5238) Cancer of the oesophagus varies widely in incidence between different parts of the world. One area of high risk is in southern and eastern Africa, where it constitutes 11.5% of cancers in men, corresponding to an annual age-standardised incidence rate of 20.7 10-5 . Previous reviews (Oettle. 1964: Cook, 1971) have drawn attention to the male excess (ranging from 1.5 to 12 in different series). and the apparent increase in incidence over time, with hospital series from the 1930s and 1940s suggesting that it was at that time a relatively rare condition. Within east and southern Africa, areas of high and low incidence are intermingled, and the sharp geographic gradients in nrsk suggest a predominant role for environmental carcinogens in the aetiology (Day and Mufioz. 1982).In al., 1970, 1976. 1993 Odds ratios (ORs) for each risk factor, with 95% confidence limits, were estimated. while controlling for potential confounding variables, by multivariate regression. using the GLIM software package (Baker and Nelder, 1978). Subjects with missing values for the variables studied were included in the analyses as a separate category. Individuals non-resident in Zimbabwe were excluded from the analysis. P-values for trend were calculated by categorising and scoring the exposure variable and treating it as continuous. ResultsNot all of the patients (or their relatives) could be interviewed, and in those who were, the questionnaire was not always completed. Overall, a complete interview was obtained in 72.6% of oesophageal cancer cases, and in 71.3% of the control group cancers.

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“…A evidente relação dose-resposta para os diferentes níveis de exposição ao fumo e à bebida fortalece a hipótese de que esses fatores têm importante papel na etiologia dessa doença. Achados semelhantes foram encontrados por outros pesquisadores 1,16,23,24,27,32,34 . Tuyns 30 (1990) destaca que o álcool é um dos poucos exemplos de substâncias químicas que parecem estar claramente envolvidas em certos tipos de câncer em humanos, especialmente os de boca, laringe, hipofaringe e esôfago, sem ter sido possível demonstrar esse fato em estudos experimentais.…”

Section: Comentáriosunclassified

“…1,16,23,27,32,34 Esteve e col. 10 (1984) afirmam que agentes cancerígenos, tanto indutores como promotores, são encontrados no tabaco e essa presença é suficiente para explicar a indução do câncer no homem.…”

Section: Comentáriosunclassified

Fatores de risco para o câncer de esôfago: estudo caso-controle em área metropolitana da região Sudeste do Brasil

et al. 1995

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O câncer de esôfago pode ser visto como um dos mais importantes sob o ponto de vista médico, devido à sua alta fatalidade e à freqüência com que ocorre em todo o mundo. É um câncer comum no norte da China, no cinturão que se estende da Rússia européia ao nordeste do Mar Cáspio, Turquia, Irã, até o centro da Ásia. É também comum na população negra do Sudeste da África. Taxas intermediárias são encontradas entre negros americanos, em regiões da França, Suíça, Japão e Separatas/Reprints:

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A case-control study of diet and social factors in cancer of the esophagus in transkei

Cited by 32 publications

References 10 publications

Absence of human papillomavirus in esophageal carcinomas from southwestern Kenya

Absence of human papillomavirus in esophageal carcinomas from southwestern Kenya

Risk factors associated with oesophageal cancer in Bulawayo, Zimbabwe

Fatores de risco para o câncer de esôfago: estudo caso-controle em área metropolitana da região Sudeste do Brasil

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