2008
DOI: 10.5021/ad.2008.20.4.267
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A Case of Acantholytic Squamous Cell Carcinoma

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Cited by 4 publications
(11 citation statements)
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“…However, later it was accepted as an uncommon variant of squamous cell carcinoma [4]. It represents 2-4% of all cutaneous squamous cell carcinoma [5], and it is usually found on the sunexposed areas of elderly patients with notable male predominance [2]. However, an increased incidence of acantholytic SCC has been recorded in organ transplant patients [6].The lesions typically arise on the head and neck as a nodule or ulcer, particularly on and around the ears and face, de novo or may develop from an actinic keratosis [5], although other less-sun-exposed locations have been reported [1], including the vulva, penis, oral mucosa, nasopharynx, and breast [2].…”
Section: Discussionmentioning
confidence: 99%
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“…However, later it was accepted as an uncommon variant of squamous cell carcinoma [4]. It represents 2-4% of all cutaneous squamous cell carcinoma [5], and it is usually found on the sunexposed areas of elderly patients with notable male predominance [2]. However, an increased incidence of acantholytic SCC has been recorded in organ transplant patients [6].The lesions typically arise on the head and neck as a nodule or ulcer, particularly on and around the ears and face, de novo or may develop from an actinic keratosis [5], although other less-sun-exposed locations have been reported [1], including the vulva, penis, oral mucosa, nasopharynx, and breast [2].…”
Section: Discussionmentioning
confidence: 99%
“…Clinicaly, it presents as a nodular, flesh colored to red, scaling, crusted, and ulcerated lesion [1], with a slow growing pattern [5]. Therefore, histological examination is necessary for making the accurate diagnosis [2].Histological characteristics include typical squamous differentiation with discrete or diffuse areas of keratinocytic acantholysis with a pseudoglandular appearance [1]. In fact, the lesional keratinocytes show a variable degree of desmosomal disruption [3], resulting in rounded free-floating single cells or small clusters of cells [6], arranged in tubular and gland-like structures, which is referred to as a "pseudoglandular" appearance [2].…”
Section: Discussionmentioning
confidence: 99%
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