A Case of Primary Cutaneous Histoplasmosis in a Patient with Diabetes and Multi‐Infarct Dementia

Abstract

We report a case of primary cutaneous histoplasmosis in a fifty-year-old African-American woman with diabetes and multi-infarct dementia. The patient developed fever and crusted, nodulo-ulcerative lesions of the skin after accidental superficial trauma to the forehead. The biopsy revealed suppurative granulomatous inflammation with intracellular and extracellular yeast-like cells with associated clear halo measuring 3-4 mm in size. Systemic involvement was not found. The lesions cleared after treatment with itraconazole 200 mg twice a day for 3 weeks. The medication was continued for a total period of 3 months, with no signs of recurrence after one-year of follow-up.

Interdigital Involvement in a Case of Primary Cutaneous Canine Histoplasmosis in Japan

“…However, this route of infection is doubtful for cutaneous canine histoplasmosis in the absence of a concomitant pulmonary disease. In the present case, as previously described in sporadic human cases with primary cutaneous histoplasmosis (Tesh and Schneidau, 1966; Krunic et al., 1995; Romano et al., 2000; Krunic et al., 2002), the possibility of percutaneous entry of micro‐organism via previous wounds on paws of the outbreed dog may need to be considered. The present case also suggested the existence of the organism in the environment (e.g.…”

Disseminated Cutaneous Histoplasmosis in an Immunocompetent Child, Relapsed with Itraconazole, Successfully Treated with Voriconazole

“…However, there have been many reports of disseminated cutaneous histoplasmosis without systemic involvement both in immunocompromised and immunocompetent patients, though more commonly in the former group (1). None of the recently reported cases in the literature (2–4) was resistant to itraconazole.…”

Cutaneous ulcer in an immunosuppressed patient with adult onset Still's disease: primary cutaneous histoplasmosis?

“…3 Although PCH has been well described in immunocompetent individuals, an increasing number of reports have accounted for the occurrence of PCH in immunocompromised adults, including in cases of diabetes mellitus. 4-6 The only description of PCH in a rheumatic autoimmune disorder dates from 2000, when a patient with rheumatoid arthritis on long-standing corticotherapy developed, like the patient in this study, an ulcerative form of the disease. 7 …”