A case of pulmonary aspergilloma cured by intracavitary infusion of 5-fluorocytosine (5-FC).

Pulmonary Aspergillosis

“…Arterial embolization 99,100 or cavernoscopic evacuation of aspergilloma 97,101 may offer an alternative method of palliation in patients at high risk for resection. Medical treatment with intravenous amphotericin B or 5-flucytosine (5-FC) is ineffective, 94,102-104 but local endobronchial or intracavitary installation of amphotericin B, [103][104][105] sodium iodide, 85,106 natamycin, 102,107 miconazole, 108 ketoconazole 102 and 5-FC 109,110 have been tried with encouraging results, although prolonged installation and recurrence even with successful lysis of the aspergilloma are common.…”

Treatment and Developmental Therapeutics in Aspergillosis. 2. Azoles and Other Antifungal Drugs

“…[80,81], In this respect, exo genously supplied purines, pyrimidines and some of their nucleoside analogues are known for their ability to antag onize the fungistatic activity of 5-FC [82,83], At doses of 100 itM, neither allopurinol nor oxypurinol altered the MIC values of 5-FC against 18 pathogenic fungal isolates [83]. Watanabe et al [84] reported the successful treat ment of 1 patient with pulmonary aspergillosis by intracav itary infusion of 5-FC. The toxic side effects of 5-FC in cluded nausea, vomiting, hcpatotoxicity and bone marrow depression [85].…”