A case of undifferentiated carcinoma arising in the mandible.

Ishii, Teruhisa; Tanaka, Takayoshi; Koizumi, Mayumi; Sakurai, Kimie; Matsuda, Yukiko; Tanaka, Haruko; Yoshimura, N.; Komiyama, Kanki

doi:10.2334/josnusd1959.32.93

Cited by 2 publications

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“…As mentioned earlier, LEC does occur in the salivary glands, and it is known to have a good prognosis with a high degree of association with EBV infection, especially in the Asian continent [5,7,9,10]. We suggest that the histogenetic origin of the tumor we describe is probably from the salivary gland inclusions in the mandible.…”

Section: Discussionsupporting

confidence: 69%

“…For example, LEC of salivary glands has better survival (an actuarial 5-year survival rate of 79.8%) [7] than LEC of the nasopharynx. With the description of the present case, the mandible is confirmed as yet another novel site for LEC/undifferentiated carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Lymphoepithelioma-like carcinoma or undifferentiated carcinoma can occur at different sites, and at each of these sites LEC has a different prognostic behavior. For example, LEC of salivary glands has better survival (an actuarial 5-year survival rate of 79.8%) [7] than LEC of the nasopharynx. With the description of the present case, the mandible is confirmed as yet another novel site for LEC/undifferentiated carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Epstein-Barr Virus–Associated Lymphoepithelioma-like Carcinoma of Mandible

et al. 2009

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We describe the first case of an lymphoepithelioma-like carcinoma (LEC) of the mandible with a view to discuss probable histogenesis from salivary gland inclusions in the mandible, effective therapy, the unusual pattern of nodal metastases, and association with the Epstein-Barr virus. An 11-year-old boy presented with a lytic lesion in the left mandible and bilateral neck node enlargement. Histologically, the biopsied metastatic neck nodes showed sinusoids distended with histiocytes and single large atypical cells that mimicked Hodgkin lymphoma. The mandibular tumor on biopsy showed morphology similar to an undifferentiated carcinoma or LEC of nasopharynx with nuclear Epstein-Barr virus-associated in situ hybridization signals. The patient received ifosfamide, cisplatin, and etoposide chemotherapy followed by a hemimandibulectomy, which did not reveal any residual tumor. Postoperative radiotherapy was completed, and 3 years later the patient is alive and free of disease.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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