A Case Report of Melanoma as Acute Mastoiditis in a 10-Month-Old Female Child

Chrysouli, Konstantina; Tsakanikos, Michael; Stamataki, Sofia

doi:10.1155/2019/9641945

Cited by 4 publications

(7 citation statements)

References 18 publications

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“…Twenty-three publications were based on a pooled total of 24 children (<18 years old) with diseases mimicking AM ( Table 2 ). 3,4,8-28 Age ranged from 10 weeks to 16 years with a male predominance (14 males, 8 females, 2 not reported). In total, 11 unique diseases were cited: acute myelogenous leukemia (AML), angiosarcoma, cranial fasciitis, Ewing sarcoma, Kawasaki disease, Langerhans cell histiocytosis (LCH), liposarcoma, melanoma, non-Hodgkin B- and T-cell lymphoma (NHL), and RMS.…”

Section: Resultsmentioning

confidence: 99%

“…Further history revealed that the girl’s mother died from melanoma when the girl was 3 months old; therefore, her melanoma likely represented fetal metastasis. Her disease underwent spontaneous regression, and she remained disease free at 4‐year follow‐up 22 …”

Section: Discussionmentioning

confidence: 96%

“…Her disease underwent spontaneous regression, and she remained disease free at 4-year follow-up. 22 Nasopharyngeal Carcinoma. NPC was identified in 3 adults.…”

Section: Solid Tumorsmentioning

confidence: 99%

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A Review of Noninfectious Diseases Masquerading as Acute Mastoiditis

Wong

Arrighi‐Allisan

Fan

et al. 2021

Otolaryngol.--head neck surg.

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Objective Acute mastoiditis is commonly attributed to infection. Rarely do clinicians encounter cases that do not respond to traditional antibiotics or surgical management. The goal of this study was to systematically review the literature to characterize diseases masquerading as acute infectious mastoiditis. Data Sources PubMed, Embase, and Scopus. Review Methods A systematic review was performed to identify all publications that reported on diseases with presentations mimicking acute mastoiditis, defined as postauricular redness, swelling, and tenderness. We included clinical prospective studies, retrospective studies, and case series/reports. Exclusion criteria included non-English articles, letters/commentaries, abstracts, and review articles. Results Out of 3339 results, 35 studies met final inclusion criteria. In children, 11 diseases were reported to mimic mastoiditis, including solid tumors, hematologic diseases, and autoimmune/inflammatory diseases. The most common disease in children was Langerhans cell histiocytosis, followed by rhabdomyosarcoma and acute myelogenous leukemia. In adults, 8 additional diseases were reported. The most common disease in adults was squamous cell carcinoma, followed by nasopharyngeal carcinoma and Langerhans cell histiocytosis. Presenting symptoms are reviewed, as well as characteristic radiographic, laboratory, and intraoperative features that may assist with diagnosis. A diagnostic algorithm for atypical cases of acute mastoiditis is proposed. Conclusion A small but significant group of diseases in children and adults can mimic acute mastoiditis. In such cases, history and examination alone may be insufficient to reach a diagnosis, and further investigation may be necessary. Otolaryngologists should always be mindful of the possibility that noninfectious pathologies may present with a constellation of symptoms similar to mastoiditis.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

A Review of Noninfectious Diseases Masquerading as Acute Mastoiditis

Wong

Arrighi‐Allisan

Fan

et al. 2021

Otolaryngol.--head neck surg.

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show abstract

“…We selected 8 cases from 10 articles (two articles described the same cases) reporting transplacental transmission of melanoma, which are summarized in Table S5. [280][281][282][283][284][285][286][287][288][289] The mean age at diagnosis was 5.3 months (range: 0.37-10), six were males, most of them presenting multiple localisations of melanoma metastasis at diagnosis. The number of melanoma-related deaths was 5, and three patients underwent spontaneous regression.…”

Section: Transplacental Melanomamentioning

confidence: 99%

Melanoma in children: A systematic review and individual patient meta‐analysis

Pampena

Piccolo²,

Mellai³

et al. 2023

Acad Dermatol Venereol

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The current evidence on paediatric melanoma is heterogeneous, especially regarding the prognosis of different histological subtypes. We sought to systematically review the evidence on paediatric melanoma, highlighting the major sources of heterogeneity and focusing on available data on single patients. A systematic search was performed from 1948 to 25 January 2021. Only studies reporting at least one case of cutaneous melanoma in patients aged ≤18 years were included. Unknown primary and uncertain malignant melanomas were excluded. Three couples of authors independently performed title/abstract screening and two different authors reviewed all the relevant full texts. The selected articles were manually cross‐checked for overlapping data for qualitative synthesis. Subsequently data on single patients were extracted to perform a patient‐level meta‐analysis. PROSPERO registration number: CRD42021233248. The main outcomes were melanoma‐specific survival (MSS) and progression‐free survival (PFS) outcomes. Separate analyses were done of cases with complete information on histologic subtype, focusing on superficial spreading (SSM), nodular (NM) and spitzoid melanomas, as well as of those classified as de‐novo (DNM) and acquired or congenital nevus‐associated melanomas (NAM). The qualitative synthesis covered 266 studies; however, data on single patients were available from 213 studies including 1002 patients. Among histologic subtypes, NM had a lower MSS than both SSM and spitzoid melanoma, and a lower PFS than SSM. Spitzoid melanoma had a significantly higher progression risk than SSM and trended toward lower mortality. Focusing on nevus‐associated status, DNM demonstrated better MSS after progression than congenital NAM, and no differences were highlighted in PFS. Our findings describe the existence of different biological patterns in paediatric melanoma. Specifically, spitzoid melanomas demonstrated intermediate behaviour between SSM and NM and showed a high risk of nodal progression but low mortality. This raises the question of whether spitzoid lesions are being over‐diagnosed as melanoma in childhood.

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“…These malignancies can erode through the temporal bone, inducing cranial nerve (CN) impairment, hearing loss, vertigo, or otalgia (8). Because of the rarity, insidious nature, and nonspecific presentation of temporal bone MM, patients may experience delays in diagnosis and treatment, as this condition may be initially misdiagnosed as serous otitis media or otomastoiditis (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Primary Temporal Bone Mucosal Melanoma

et al. 2022

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Objective: Temporal bone mucosal melanomas (MMs) are rare, and patients may experience delays in diagnosis and treatment. Our objective was to better characterize the presentation, diagnosis, treatment modalities, and outcomes of this process. Data Sources: PubMed/Medline, CINAHL (EBSCOhost), and Web of Science databases were searched in all languages without restriction of publication dates. Study Selection: Inclusion criteria included that the article was either a case report or a case series with individual case data. All non-English articles were excluded if the corresponding abstract lacked data on demographics, initial presentation, and clinical management. Data Extraction: After full-text analysis, data pertaining to demographics, diagnosis, medical and surgical management modalities, and outcomes were extracted.Data Synthesis: Data were qualitatively synthesized, and means and averages were obtained for all continuous variables. Overall survival was measured by the Kaplan-Meier method, and significance was measured through log-rank testing. Conclusions: Clinicians should suspect temporal bone MM in the differential diagnosis of patients with bloody otorrhea in the context of a chronic serous otitis media or an associated cranial nerve palsy. If suspected, physicians should not delay the acquisition of a biopsy or imaging studies. Management is highly variable and must be decided on a case-by-case basis. Outcomes remain poor because of the high propensity for MM to metastasize.

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A Case Report of Melanoma as Acute Mastoiditis in a 10-Month-Old Female Child

Cited by 4 publications

References 18 publications

A Review of Noninfectious Diseases Masquerading as Acute Mastoiditis

A Review of Noninfectious Diseases Masquerading as Acute Mastoiditis

Melanoma in children: A systematic review and individual patient meta‐analysis

A Systematic Review of Primary Temporal Bone Mucosal Melanoma

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