A Case Report of Metastatic Gallbladder Cancer as The Cause of Acute Appendicitis

Aksade, Artun; Ewing, Edward; Benavides, Francisco; Marchese, Valentina

doi:10.31487/j.jso.2019.03.02

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…Primary appendiceal neoplasms are incidentally found in 1-2% of appendectomies, with mucinous neoplasm (0.6%) and carcinoids (0.3-0.9) being the most common lesions [ 10 , 11 ]. Metastatic involvement of the appendix presenting as acute appendicitis is an even rarer entity, with few case reports documenting such incidences from carcinoma of breast, ovary, prostate, lung, kidney, stomach, colon, and hepatobiliary tract [ 12 – 18 ]. Unlike the growth pattern typical of primary appendiceal carcinoma, which starts from the mucosa and progresses outward, metastasis to the appendix involves the serosa first, followed by inward infiltration [ 14 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

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A Unique Presentation of Metastatic Gallbladder Carcinoma

Tian

Luu

Carpenter

et al. 2021

Case Reports in Surgery

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Gallbladder carcinoma can be challenging to diagnose and treat and usually leads to poor outcome, due to its aggressive nature and the nonspecific clinical presentation at early stage. We describe an interesting case of a 60-year-old female who presented with stage 3 appendiceal carcinoma after appendectomy was performed outside hospital. Further imaging workup demonstrated enlarged ovarian cysts and porcelain gallbladder. Upon exploration, she was found to have carcinomatosis and we proceeded with cytoreductive surgery (CRS) and hyperthermic intraperitoneal therapy (HIPEC). Final pathology demonstrated carcinoma from gallbladder primary.

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Section: Discussionmentioning

confidence: 99%

“…There are only two case reports found in the literature documenting gallbladder cancer metastasis to the appendix and only one of them presented as acute appendicitis clinically [ 16 , 18 ]. Another case report described a metastatic cholangiocarcinoma mimicking acute appendicitis [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

A Unique Presentation of Metastatic Gallbladder Carcinoma

Tian

Luu

Carpenter

et al. 2021

Case Reports in Surgery

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“…There was one low-grade serous ovarian carcinoma metastasis [67] causing perforated appendicitis. The other cases included hepatocellular carcinoma [68], choriocarcinoma of the mediastinum [69] granular cell tumor [70] acute promyelocytic leukemia [71], nasopharyngeal carcinoma [72], non-seminomatous testicular cancer [73], testicular seminoma [74], inflammatory myofibroblastic tumour [75], two cases of Kaposi's sarcoma [76,77] a natural killer cell/ T cell lymphoma [78], two cases of appendiceal schwannoma [79,80], two cases of cholangiocarcinoma [81,82], a case of metastatic gallbladder carcinoma [83,84], and two cases of pancreatic adenocarcinoma [85,86]. In our results, there was a total of 46%(n=34) of individuals with complicated appendicitis, 54%(n=40) with uncomplicated appendicitis, and 4 cases did not have degree of inflammation documented.…”

Section: Othersmentioning

confidence: 99%

Acute Appendicitis Secondary to Metastatic Malignancy - A Review of 78 Cases in Literature

2023

J Surg

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Background: Acute appendicitis is one of the most common causes of acute abdomen presentation to the emergency department. Appendicectomy is one of the most common emergency operations performed. Appendicitis is attributed to lymphoid hyperplasia or faecolith causing obstruction of the appendiceal lumen. Other causes include helminth infection, primary appendiceal tumours, malignancy, and calculi. Metastatic malignancy causing acute appendicitis is very uncommon. In this article, we review the literature that exists reporting acute appendicitis attributed to metastatic diseases of the appendix, the malignancies that were identified, and the nature of the presentation. Methods:This study was performed following the Scale for the Assessment of Narrative Review Articles (SANRA). A literature review of existing case reports, abstracts, and studies was performed. PubMed and Google Scholar were used to search for the articles. Several cases were identified using the 'snowball method' where references were used to identify additional published literature.Results: Seventy-eight cases of acute appendicitis secondary to metastatic malignancies were identified. The most commonly reported metastatic malignancy causing appendicitis were breast, lung, gastric, and prostate. There was a total of n=34 (46%) of individuals with complicated appendicitis, n=40 (54%) with uncomplicated appendicitis, and four cases did not have degree of inflammation documented. The mean age of the patients was 57 years old. Conclusion:Appendicitis secondary to metastatic disease is a rare entity. This literature review has collated data identifying known primary malignancies that are associated with metastatic disease to the appendix. The most common have been identified as breast, lung, gastric and prostate primary malignancies. The mean age of patients in this review is 57. Patients presented with more complicated disease in comparison to the general population with acute appendicitis without malignancy. While rare, it important to be cognizant to the patient's previous malignancies even after the surveillance period has been completed. In this article we review the literature that exists reporting acute appendicitis attributed to secondary metastatic disease of the appendix, the malignancies that were identified and the nature of the presentation. When considering management of appendicitis, it is important to be cognizant as to whether the patient has had previous malignancies even after the surveillance period is over.

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“…En una revisión de la literatura, que evaluó retrospectivamente los hallazgos histopatológicos de apendicetomías, solo 7 pacientes evidenciaron compromiso metastásico, de un total de 80 698 (7) , cifra muy significativa y que pone en perspectiva lo inusual de dicha presentación. De los sitios primarios de metástasis en este estudio no se reportó la vía biliar, siendo esta una presentación atípica (8) .…”

Section: Reporte De Casounclassified

Reporte de caso de neoplasia biliar metastásica como causa inusual de apendicitis

Amaya

López

Marrugo

et al. 2022

Rev. colomb. Gastroenterol.

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Introducción: se describe el caso de una paciente con una metástasis apendicular como primera manifestación encontrada de un colangiocarcinoma. Síntomas principales: expresado con dolor abdominal, ictericia, hiporexia y coluria. Métodos y resultados: se documentó un plastrón apendicular histológicamente compatible con adenocarcinoma apendicular metastásico, estrechez del conducto hepático común, con alta sospecha de colangiocarcinoma, corroborado luego con la realización de una colangiopancreatografía retrógrada endoscópica. Conclusiones: los tumores apendiculares metastásicos son una presentación infrecuente y poco estudiada, donde los secundarios a neoplasia de vía biliar se han reportados de forma muy escasa en la literatura.

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A Case Report of Metastatic Gallbladder Cancer as The Cause of Acute Appendicitis

Cited by 3 publications

References 8 publications

A Unique Presentation of Metastatic Gallbladder Carcinoma

A Unique Presentation of Metastatic Gallbladder Carcinoma

Acute Appendicitis Secondary to Metastatic Malignancy - A Review of 78 Cases in Literature

Reporte de caso de neoplasia biliar metastásica como causa inusual de apendicitis

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