A cell-free therapy for articular cartilage repair based on synergistic delivery of SDF-1 &amp; KGN with HA injectable scaffold

Wu, Huachu; Shen, Liang; Zhu, Zhu; Luo, Xiang; Zhai, Yishu; Hua, Xiaobin; Zhao, Shicheng; Chen, Lian; Zhang, Zhibing

doi:10.1016/j.cej.2020.124649

Cited by 43 publications

(34 citation statements)

References 42 publications

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“…83,207 In addition, microfluidic technology has been used to form core-shell microspheres. 208 This technique enables multiple drugs to be loaded simultaneously for the microspheres to serve as sites for tissue regeneration with long-lasting efficacy. In one study, researchers coencapsulated SDF-1 and KGN within core-shell microspheres FIG.…”

Section: Controlled Sustained-release Delivery Strategiesmentioning

confidence: 99%

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Advanced Polymer-Based Drug Delivery Strategies for Meniscal Regeneration

Yang

et al. 2021

Tissue Engineering Part B: Reviews

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The meniscus plays a critical role in maintaining knee joint homeostasis. Injuries to the meniscus, especially considering the limited self-healing capacity of the avascular region, continue to be a challenge and are often treated by (partial) meniscectomy, which has been identified to cause osteoarthritis. Currently, meniscus tissue engineering focuses on providing extracellular matrix (ECM)-mimicking scaffolds to direct the inherent meniscal regeneration process, and it has been found that various stimuli are essential. Numerous bioactive factors present benefits in regulating cell fate, tissue development, and healing, but lack an optimal delivery system. More recently, bioengineers have developed various polymer-based drug delivery systems (PDDSs), which are beneficial in terms of the favorable properties of polymers as well as novel delivery strategies. Engineered PDDSs aim to provide not only an ECM-mimicking microenvironment but also the controlled release of bioactive factors with release profiles tailored according to the biological concerns and properties of the factors. In this review, both different polymers and bioactive factors involved in meniscal regeneration are discussed, as well as potential candidate systems, with examples of recent progress. This article aims to summarize drug delivery strategies in meniscal regeneration, with a focus on novel delivery strategies rather than on specific delivery carriers. The current challenges and future prospects for the structural and functional regeneration of the meniscus are also discussed.

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Section: Controlled Sustained-release Delivery Strategiesmentioning

confidence: 99%

“…The injectable scaffold was tested in a rabbit articular cartilage defect model and presented efficient therapeutic effects for cartilage regeneration; thus, this approach may also serve as a novel cell-free therapy for meniscal regeneration. 208 Preprogrammed delivery strategies…”

Section: Controlled Sustained-release Delivery Strategiesmentioning

confidence: 99%

Advanced Polymer-Based Drug Delivery Strategies for Meniscal Regeneration

Yang

et al. 2021

Tissue Engineering Part B: Reviews

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“…Depending on the purpose, these core-shell particles have varying core shapes, internal structures, shell thicknesses, and surface morphologies. These factors are the key determinants of loading efficiency and release kinetics [8]. The size of the microspheres usually ranges between 10-200 µm because too small microspheres (< 10 µm) will get engulfed by immune cells and too big microspheres (> 200 µm) will cause inflammation [8].…”

Section: Introductionmentioning

confidence: 99%

“…These factors are the key determinants of loading efficiency and release kinetics [8]. The size of the microspheres usually ranges between 10-200 µm because too small microspheres (< 10 µm) will get engulfed by immune cells and too big microspheres (> 200 µm) will cause inflammation [8]. Numerous techniques for synthesizing core-shell microspheres are developed, including polymerization, spray drying, solvent evaporation, and self-assembly [9].…”

Section: Introductionmentioning

confidence: 99%

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PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application

Patel

2021

Polymers

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Core–shell particles are very well known for their unique features. Their distinctive inner core and outer shell structure allowed promising biomedical applications at both nanometer and micrometer scales. The primary role of core–shell particles is to deliver the loaded drugs as they are capable of sequence-controlled release and provide protection of drugs. Among other biomedical polymers, poly (lactic-co-glycolic acid) (PLGA), a food and drug administration (FDA)-approved polymer, has been recognized for the vehicle material. This review introduces PLGA core–shell nano/microparticles and summarizes various drug-delivery systems based on these particles for cancer therapy and tissue regeneration. Tissue regeneration mainly includes bone, cartilage, and periodontal regeneration.

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Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

et al. 2023

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Cartilage degeneration is among the fundamental reasons behind disability and pain across the globe. Numerous approaches have been employed to treat cartilage diseases. Nevertheless, none have shown acceptable outcomes in the long run. In this regard, the convergence of tissue engineering and microfabrication principles can allow developing more advanced microfluidic technologies, thus offering attractive alternatives to current treatments and traditional constructs used in tissue engineering applications. Herein, the current developments involving microfluidic hydrogel‐based scaffolds, promising structures for cartilage regeneration, ranging from hydrogels with microfluidic channels to hydrogels prepared by the microfluidic devices, that enable therapeutic delivery of cells, drugs, and growth factors, as well as cartilage‐related organ‐on‐chips are reviewed. Thereafter, cartilage anatomy and types of damages, and present treatment options are briefly overviewed. Various hydrogels are introduced, and the advantages of microfluidic hydrogel‐based scaffolds over traditional hydrogels are thoroughly discussed. Furthermore, available technologies for fabricating microfluidic hydrogel‐based scaffolds and microfluidic chips are presented. The preclinical and clinical applications of microfluidic hydrogel‐based scaffolds in cartilage regeneration and the development of cartilage‐related microfluidic chips over time are further explained. The current developments, recent key challenges, and attractive prospects that should be considered so as to develop microfluidic systems in cartilage repair are highlighted.

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A cell-free therapy for articular cartilage repair based on synergistic delivery of SDF-1 & KGN with HA injectable scaffold

Cited by 43 publications

References 42 publications

Advanced Polymer-Based Drug Delivery Strategies for Meniscal Regeneration

Advanced Polymer-Based Drug Delivery Strategies for Meniscal Regeneration

PLGA Core-Shell Nano/Microparticle Delivery System for Biomedical Application

Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

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