A Chromosomal Gene for Chloramphenicol Acetyltransferase in Streptomyces acrimycini

Wright, Helen; Hopwood, David A.

doi:10.1099/00221287-102-2-417

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…No chemical investigation of the S. acrimycini secondary metabolites has been previously reported, but only genetic and morphological descriptions. [8][9][10][11] Although there is abundant literature data about dipeptides isolated from microbial sources, 12,16 their true origin remains controversial. Some authors suggest that dipeptides are fermentation artifacts, generated by hydrolysis of proteins present in the growth media.…”

Section: Resultsmentioning

confidence: 99%

Dipeptide metabolites from the marine derived bacterium Streptomyces acrymicini

Hernandez¹,

Macedo²,

Berlinck³

et al. 2004

J. Braz. Chem. Soc.

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A investigação química do extrato bruto obtido a partir do meio de crescimento do actinomiceto Streptomyces acrimycini isolado de sedimentos marinhos levou ao isolamento de dois dipeptídeos: a 8-amino-[1,4]diazonano-2,5-diona (1) e leucil-4-hidroxiprolina (3). Os compostos foram isolados a partir do seu meio de crescimento por uma série de etapas cromatográficas e identificados pela análise de seus dados espectroscópicos. O esqueleto macrocíclico da 8-amino-[1,4]diazonano-2,5-diona foi descrito apenas uma vez nas marinobactinas, sideróforos isolados a partir de uma bactéria marinha do gênero Marinobacter.The chemical investigation of the crude extract obtained from the growth media of the marinederived actinomycete Streptomyces acrimycini isolated from marine sediments led to the isolation of two new dipeptide derivatives: 8-amino-[1,4]diazonane-2,5-dione (1) and leucyl-4-hydroxyproline (3). The dipeptides were isolated from the growth media by a series of chromatographic steps, and identified by analysis of spectroscopic data. The macrocyclic carbon backbone of 8-amino-[1,4]diazonane-2,5-dione has been previously reported only once in marinobactins, siderophores isolated from the marine bacterium Marinobacter sp.

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Section: Resultsmentioning

confidence: 99%

Dipeptide metabolites from the marine derived bacterium Streptomyces acrymicini

Hernandez¹,

Macedo²,

Berlinck³

et al. 2004

J. Braz. Chem. Soc.

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“…In a study initiated with a different objective, Wright & Hopwood (1977) found that the same strain of S. acrimycini gave rise to Cmls variants at a similar frequency (e.g. 1 % spontaneously and 4 yo after U.V.…”

Section: R E S U L T Smentioning

confidence: 99%