A Clinical and Microbiological Profile of Urinary Tract Infection in Diabetes Mellitus Patients, a South India Perceptive

Abstract

Introduction:Asymptomatic bladder infection that is detected by a positive urine culture is also common among diabetes mellitus patient which progress to symptomatic infection and subsequent complication. Therefore it becomes essential to screen urinary tract infection in diabetes mellitus patient so that its progress to complication can be prevented. Hence present study has been designated to know the clinical, microbiological profile and antimicrobial sensitivity pattern of organism that causes UTI in diabetes mellitus patient. Material and methods: Based on exclusion and inclusion criteria 100 patients were included in this study, A detailed history of the patient were taken with respect to duration of diabetes and its symptoms complication, type and treatment. Regarding urinary tract infection, history was taken with respect to dysuria, burning, suprapubic pain; urgency, increased frequency and haematuria fever with chill rigor and vomiting suggestive of acute pylonephritis. Result: Out of 100 patients 36 patients have bacteriuria and 64 patients were without bacteriuria. Patient with HbA1C% above 10, who were suffering from UTI were 43, out of them 21 having bacteria in urine. The P value was 0.0642 and chisquare statistic was 5.496, which is not significant. Regarding relation between FPG and UTI, those patient whose FPG was less than 110mg/dl., five of them have UTI and four have bacteria in urine and one were without bacteriuria. Conclusion: bacteriuria was more common in female then male and patient above 50 year of age are more affected then younger one. Patient with type 2 diabetes mellitus and treated with oral hypoglycaemic agent are effected more frequently. Bacteriuria was more common in patient whose glycocylated haemoglobin was more than 10% and fasting plasma glucose was more than 200mg/dl. Patients having neuropathy are more prone to UTI. Most common organism isolate were E.Coli and were sensitive to cephalosporins and aminoglycosides.

Urinary tract infection and Diabetes Mellitus—Etio-clinical profile and antibiogram

“…The antimicrobial resistance pattern was similar in participants of both the groups with maximum sensitivity to Colistin and minimum sensitivity to Amoxicillin. This is in agreement with the other Indian[ 15 16 17 21 23 24 25 ] and South Asian studies. [ 18 26 27 28 ] Diabetics had relatively lesser symptoms and more severe forms of UTI at presentation and less favorable outcomes.…”

The occurrence of urinary tract infection and determinant factors among diabetic patients at Dessie Referral Hospital, South Wollo, Northeast Ethiopia

“…In the meantime, the finding was higher in another study cited from Ethiopia Gondar University Hospital, Gondar (17.4%), Debre Tabor General Hospital (10.1%), five hospitals in Harar (15.4%), Hawassa University Referral Hospital (13.8%), Nekemte Referral Hospital (NRH; 16.1%), Metu Karl Heinz Referral Hospital (16.7%), 14,16,21,[28][29][30] and in abroad, Mbarara Regional Referral Hospital in Uganda (13.3%), 10 Nanjing First Hospital in China (11.2%), 31 Tamil Nadu, India (12.2%), 32 Timisoara Hospital of Romania (12%), 33 General Hospital in Pakistan (13.6%), 34 and a study conducted in Dodoma Regional Referral Hospital, Tanzania (15.5%). 35 The variation in magnitude might be due to differences in socio-demographic characteristics of the study setting.…”

“…This was based on previous studies conducted in Harar, south Ethiopia, Debre Tabor General Hospital, Arba Minch Hospital, Metu Karl Heinz, and Hawassa University Referral Hospital, 13,14,16,28,30 Malaysia, Pakistan, and Tanzania. 4,[33][34][35] The higher risk of infection in females might be due to the fact women are vulnerable to UTIs due to their anatomy and reproductive physiology. Short urethra and closer to a perirectal area where pathogen colonizes easier, absence of bacteriostatic prostatic secretions and sexual intercourse may force bacteria into the female bladder.…”