A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission

Ooi, Jun; Iseki, Tohru; Takahashi, Satoshi; Tomonari, Akira; Nagayama, Hitomi; Ishii, K.; Itō, Kiyoshi; Sato, Hiroyuki; Takahashi, Tsutomu; Shindo, Motohiro; Sekine, Rieko; Ohno, Nobuhiro; Uchimaru, Kaoru; Nagamura, Fumitaka; Shirafuji, Naoki; Tojo, Arinobu; Tani, Kenzaburo; Asano, Shigetaka

doi:10.1046/j.1365-2141.2002.03650.x

Cited by 51 publications

(28 citation statements)

References 12 publications

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“…Outcomes after unrelated CBT in adults are comparable to those obtained after unrelated BMT 55,56 and poorer than those obtained in children. 40,49 Best results have been achieved in young adults in the early phase of their disease.…”

Section: Unrelated Cbt In Adultssupporting

confidence: 50%

Hematopoietic stem cell transplantation using umbilical cord blood progenitors: review of current clinical results

Benito

Díaz

González‐Vicent

et al. 2004

Bone Marrow Transplant

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Summary:Umbilical cord blood (CB) has been rapidly established as an alternative source of stem cells to bone marrow for allogeneic-related and unrelated hematopoietic transplantation. To date, almost 70 000 CB units are available for transplantation and more than 2000 CB transplants (CBT) have been performed, mostly in children, for the treatment of a variety of malignant and nonmalignant conditions. Considerable experience has been rapidly accumulated in this field and many aspects of CBT have been elucidated, while other questions remain unresolved. A concise review of the clinical results achieved after related and unrelated CBT is presented and discussed.

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Section: Unrelated Cbt In Adultssupporting

confidence: 50%

Hematopoietic stem cell transplantation using umbilical cord blood progenitors: review of current clinical results

Benito

Díaz

González‐Vicent

et al. 2004

Bone Marrow Transplant

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“…This may be one of the possible reasons for our favorable result. Although several studies have suggested the promising results of unrelated CBT for adult patients, [16][17][18] the role of unrelated cord blood as an alternative stem cell source is not well defined in adult MDS patients. Therefore, we updated the results of unrelated CBT for adult MDS patients.…”

Section: Resultsmentioning

confidence: 99%

Unrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome

Ooi

Iseki

Takahashi

et al. 2003

Blood

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We report the results of unrelated cord blood transplantation (CBT) for 13 adult patients with advanced myelodysplastic syndrome (MDS). The median age was 40 years, the median weight was 51 kg, and the median number of infused nucleated cells was 2.43 ؋ 10 7 /kg. Twelve patients had myeloid reconstitution, and the median time to more than 0.5 ؋ 10 9 /L (5 ؋ 10 8 /L) absolute neutrophil count was 22.5 days. A self-sustained platelet count more than 50 ؋ 10 9 /L was achieved in 11 patients at a median time of 49 days. Acute graft versus host disease (GVHD) occurred in 9 of 12 evaluable patients and chronic GVHD in 8 of 11 evaluable patients. Ten patients are alive and free of disease at between 171 and 1558 days after transplantation. The probability of disease-free survival at 2 years was 76.2%.

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“…More rapid hematopoietic recovery in UCB recipients of higher cell doses was reported. [14][15][16] Wagner Table 3 Univariate analyses of transplant-related parameters in the cohort of 65 patients Patient characteristics n Graft failure Acute GvHD Xgrade II a Transplant-related mortality at day 100 b 6-year survival b n/n (%) P n/n (%) P n /n (%) P n /n (%) P et al 13 noted a high survival rate in recipients of no more than two HLA-mismatched UCB grafts that contained at least 1.7 Â 10 5 CD34 þ cells/kg of recipient body weight. Gluckman et al 17 observed no correlations of the number of HLA disparities to the treatment-related mortality and the overall survival of UCB recipients, despite the fact that the higher the number of HLA disparities, the higher the probability of acute GvHD grades III and IV and the lower the risk of relapse.…”

Section: Discussionmentioning

confidence: 99%

Indiscernible benefit of high-resolution HLA typing in improving long-term clinical outcome of unrelated umbilical cord blood transplant

Liao

et al. 2007

Bone Marrow Transplant

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The success of allogeneic hematopoietic stem cell transplantation depends in part on the accuracy of human leukocyte antigen (HLA) matching between the donorrecipient pair. The higher the number of matching HLA alleles, the smaller the chance that the transplant recipient will develop complications. Umbilical cord blood (UCB) transplantation was noted to result in a remarkably low frequency and severity of graft-versus-host disease (GvHD) and graft rejection compared to that in unrelated bone marrow transplant recipients. At present most banks match UCB donors for respective recipients by HLA-A, -B low-resolution typing and -DRB1 high-resolution typing. We retrospectively conducted high-resolution sequence-based HLA typing on DNA samples available from 65 Chinese UCB-recipient pairs typed previously by using low-resolution sequence-specific oligonucleotide probes and sequence-specific primers, and evaluated the clinical outcome. High-resolution typing revealed imperceptible HLA alleles that were hardly identified in lowresolution typing. Univariate analyses demonstrated no significant correlation between the extents of highresolution HLA disparity with engraftment, graft failure, acute GvHD, transplant-related mortality and long-term 6-year overall survival. Data from the study suggest that high-resolution typing for HLA-A, -B and -DRB1 contributed no substantial improvement to UCB transplant outcome. Low-resolution typing appears to be amenable to matching UCB-recipient pairs without compromising the quality of transplant.

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A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission

Cited by 51 publications

References 12 publications

Hematopoietic stem cell transplantation using umbilical cord blood progenitors: review of current clinical results

Hematopoietic stem cell transplantation using umbilical cord blood progenitors: review of current clinical results

Unrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome

Indiscernible benefit of high-resolution HLA typing in improving long-term clinical outcome of unrelated umbilical cord blood transplant

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