A Clinical, Epidemiologic, Serologic, and Virologic Study of Influenza C Virus Infection

Dykes, Aubert C.; Cherry, James D.; Nolan, Carolyn

doi:10.1001/archinte.1980.00330210043021

Cited by 54 publications

(17 citation statements)

References 14 publications

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“…Seropositivity increased with age, with 64% seropositivity in children 0-5, 96% in children 6-10, and 98% in adults 16-25 years. Stability of HAI titer across age groups suggested periodic reinfection that maintained antibody titers [74].…”

Section: Seroepidemiologymentioning

confidence: 99%

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Epidemiology and Clinical Characteristics of Influenza C Virus

Sederdahl

Williams

2020

Viruses

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Influenza C virus (ICV) is a common yet under-recognized cause of acute respiratory illness. ICV seropositivity has been found to be as high as 90% by 7-10 years of age, suggesting that most people are exposed to ICV at least once during childhood. Due to difficulty detecting ICV by cell culture, epidemiologic studies of ICV likely have underestimated the burden of ICV infection and disease. Recent development of highly sensitive RT-PCR has facilitated epidemiologic studies that provide further insights into the prevalence, seasonality, and course of ICV infection. In this review, we summarize the epidemiology and clinical characteristics of ICV.

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Section: Seroepidemiologymentioning

confidence: 99%

“…Seasonality of ICV is poorly understood, although outbreaks and cases of familial transmission have been described [74,101]. Matsuzaki et al found in a multi-year Japanese study that the peak of ICV was in May during biennial epidemics in even-numbered years [60].…”

Section: Seasonalitymentioning

confidence: 99%

Epidemiology and Clinical Characteristics of Influenza C Virus

Sederdahl

Williams

2020

Viruses

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“…Influenza C virus infections are generally mild and self-limited but can also cause more severe lower respiratory tract illness, such as bronchitis and pneumonia [1,2]. The infection is considered common based on high seroprevalence [3,4,5].…”

Section: Introductionmentioning

confidence: 99%

Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses

Furuse

Matsuzaki

Nishimura

et al. 2016

Viruses

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Infections with the influenza C virus causing respiratory symptoms are common, particularly among children. Since isolation and detection of the virus are rarely performed, compared with influenza A and B viruses, the small number of available sequences of the virus makes it difficult to analyze its evolutionary dynamics. Recently, we reported the full genome sequence of 102 strains of the virus. Here, we exploited the data to elucidate the evolutionary characteristics and phylodynamics of the virus compared with influenza A and B viruses. Along with our data, we obtained public sequence data of the hemagglutinin-esterase gene of the virus; the dataset consists of 218 unique sequences of the virus collected from 14 countries between 1947 and 2014. Informatics analyses revealed that (1) multiple lineages have been circulating globally; (2) there have been weak and infrequent selective bottlenecks; (3) the evolutionary rate is low because of weak positive selection and a low capability to induce mutations; and (4) there is no significant positive selection although a few mutations affecting its antigenicity have been induced. The unique evolutionary dynamics of the influenza C virus must be shaped by multiple factors, including virological, immunological, and epidemiological characteristics.

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“…[1][2][3] More than 80% of humans acquire antibodies to the virus by the age of 7-10 years, which suggests that influenza C virus infection is common during childhood. [4][5][6] Recently, studies on influenza C virus infection were reported from Spain, 7,8 France, 9 Cuba 10 and Nigeria. 11 Their method of detection of influenza C virus used molecular techniques.…”

Section: Introductionmentioning

confidence: 99%