“…In humans, stress may act indirectly by inducing unhealthy lifestyles like smoking, reduced physical activity, and increased calorie intake, thus worsening cardiovascular risk. 4,5,11 Stress may also act directly 1,4,12 by affecting major regulatory systems, in particular, the hypothalamic-pituitary-adrenal axis 4,13 and the autonomic nervous system (ANS), 14 -18 leading to abnormal catecholamine release impairing vascular performance, 19 inappropriately elevated sympathetic drive, and, thus, contributing to increase arterial pressure. 20 In view of the intrinsic dynamic nature of autonomic regulation, to capture more easily the effects of work related stress, it may be useful to plan studies at the worksite instead of in the more usual clinical laboratory, where environmental factors may act differently.…”