A clinical study of platelet rich plasma versus conventional dressing in management of diabetic foot ulcers

Prakasam, Nithyaraj; Prabakar,; Reshma, S; Loganathan, K.; Senguttuvan, K.

doi:10.18203/2349-2902.isj20184069

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…We found that common site was mid foot seen in 35 and 30 in group II, fore foot seen 20 in group I and 18 in group II, hind foot seen 5 in group I and 12 in group II. Prakasam et al [10] compared Platelet-Rich Plasma versus conventional dressing in the management of diabetic foot ulcers. Group A received conventional ordinary dressing (N=10, 50%) and Group B received PRP dressing (N = 10, 50%).…”

Section: Discussionmentioning

confidence: 99%

Conventional Ordinary and PRP in Management of Diabetic Foot Ulcer- A Comparative Study

Agarwal¹,

Majumdar²

2019

AJS

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Background: Diabetes mellitus is a clinical syndrome characterized by hyperglycemia caused by absolute or relative deficiency of insulin. The present study was conducted to compare PRP and conventional dressing in management of diabetic foot ulcer. Subjects and Methods: The present study was conducted on 120 patients with diabetic foot ulcers. Patients were divided into 2 groups of 60 each. Group I was those who received conventional dressing and group II patients received PRP dressings. Patients were examined and recalled regularly to see effect of dressing and size of the lesions. Results: Common site was mid foot seen in 35 and 30 in group II, fore foot seen 20 in group I and 18 in group II, hind foot seen 5 in group I and 12 in group II. The difference was non-significant (P> 0.05). At 0 week mean size of DFU was 4.2 mm in group I and 4.1 mm in group II, at 1 week was 4.0 mm in group I and 3.8 mm in group II, at 3rd week was 3.6 mm in group I and 2.4 mm in group II and 2.6 mm in group I and 1.2 mm in group II. The difference was significant (P< 0.05). Conclusion: Platelet rich plasma was effective in the management of diabetic foot ulcer. There was comparatively increase in size reduction in PRP group than conventional group.

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Section: Discussionmentioning

confidence: 99%

Conventional Ordinary and PRP in Management of Diabetic Foot Ulcer- A Comparative Study

Agarwal¹,

Majumdar²

2019

AJS

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Evaluation of Quality of Life in Patients with Chronic Leg Wounds: Can Platelet-rich Plasma Therapy Help?

Rainys

Čepas

Rimdeika

2020

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Aim. The aim of the study was to evaluate and compare the quality of life (QoL) using platelet-rich plasma gel (PRP) and conventional treatment of chronic leg wounds. Methods. Randomized clinical trial was carried out in Hospital of Lithuanian University of Health Sciences Kaunas Clinics during 2014–2018. Patients (n = 69) included in the study were randomly grouped into 2 groups: 1) PRP, 2) Control. SF-36 questionnaire was used to evaluate QoL, visual analog scale was used to evaluate persistent pain associated with ulcer and wound exudate volume was also evaluated. Statistical analysis were performed with SPSS 23.0 package. Results. Patients in PRP group at the end of the treatment rated their QoL over control group patients (p < 0.05). Wound associated pain (PRP – 1.54; control – 2.85; p = 0.015) and pain associated sleep disturbance (p < 0.001) was lower in PRP group patients. Wound exudate volume was lower in PRP group patients at the end of the treatment (p < 0.05). Conclusion. The treatment with PRP is associated with less wound associated pain, less-common sleep disturbance, reduced wound secretion and improved quality of life compared to conventional treatment.

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Evolving spectrum of diabetic wound: Mechanistic insights and therapeutic targets

Chakraborty¹,

Borah²,

Dutta³

et al. 2022

WJD

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Diabetes mellitus is a chronic metabolic disorder resulting in an increased blood glucose level and prolonged hyperglycemia, causes long term health conse-quences. Chronic wound is frequently occurring in diabetes patients due to compromised wound healing capability. Management of wounds in diabetic patients remains a clinical challenge despite many advancements in the field of science and technology. Increasing evidence indicates that alteration of the biochemical milieu resulting from alteration in inflammatory cytokines and matrix metalloproteinase, decrease in fibroblast and keratinocyte functioning, neuropathy, altered leukocyte functioning, infection, etc. , plays a significant role in impaired wound healing in diabetic people. Apart from the current pharmacotherapy, different other approaches like the use of conventional drugs, antidiabetic medication, antibiotics, debridement, offloading, platelet-rich plasma, growth factor, oxygen therapy, negative pressure wound therapy, low-level laser, extracorporeal shock wave bioengineered substitute can be considered in the management of diabetic wounds. Drugs/therapeutic strategy that induce angiogenesis and collagen synthesis, inhibition of MMPs, reduction of oxidative stress, controlling hyperglycemia, increase growth factors, regulate inflammatory cytokines, cause NO induction, induce fibroblast and keratinocyte proliferation, control microbial infections are considered important in controlling diabetic wound. Further, medicinal plants and/or phytoconstituents also offer a viable alternative in the treatment of diabetic wound. The focus of the present review is to highlight the molecular and cellular mechanisms, and discuss the drug targets and treatment strategies involved in the diabetic wound.

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A clinical study of platelet rich plasma versus conventional dressing in management of diabetic foot ulcers

Cited by 3 publications

References 26 publications

Conventional Ordinary and PRP in Management of Diabetic Foot Ulcer- A Comparative Study

Conventional Ordinary and PRP in Management of Diabetic Foot Ulcer- A Comparative Study

Evaluation of Quality of Life in Patients with Chronic Leg Wounds: Can Platelet-rich Plasma Therapy Help?

Evolving spectrum of diabetic wound: Mechanistic insights and therapeutic targets

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