A clinical trial of nicergoline to prevent temporary threshold shift

Klamkam, Pana; Pagcharoenpol, Rongrat; Treesaranuwattana, Treewit; Silpsrikul, Pichayen; Jaruchinda, Pariyanan; Wasuwat, Piyalarp; Suwannahitatorn, Picha

doi:10.1002/lio2.746

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…The daily dose should be 30-60 mg [62]. Side effects are rare and usually include nausea, dizziness, diarrhea, fainting, and headache [73,74]. Due to the lack of experience with nicergoline in pregnant women, it is not recommended during pregnancy and lactation [74].…”

Section: Nicergolinementioning

confidence: 99%

Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs

Malík

Tlustos

2022

Nutrients

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Nootropics, also known as “smart drugs” are a diverse group of medicinal substances whose action improves human thinking, learning, and memory, especially in cases where these functions are impaired. This review provides an up-to-date overview of the potential effectiveness and importance of nootropics. Based on their nature and their effects, this heterogeneous group of drugs has been divided into four subgroups: classical nootropic compounds, substances increasing brain metabolism, cholinergic, and plants and their extracts with nootropic effects. Each subgroup of nootropics contains several main representatives, and for each one, its uses, indications, experimental treatments, dosage, and possible side effects and contraindications are discussed. For the nootropic plant extracts, there is also a brief description of each plant representative, its occurrence, history, and chemical composition of the medicinal part. Lastly, specific recommendations regarding the use of nootropics by both ill and healthy individuals are summarized.

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Section: Nicergolinementioning

confidence: 99%

Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs

Malík

Tlustos

2022

Nutrients

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A clinical trial of nicergoline to prevent temporary threshold shift

Klamkam

Pagcharoenpol

Treesaranuwattana

et al. 2022

Laryngoscope Investig Oto

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Objective To evaluate the effectiveness of nicergoline to prevent temporary threshold shift (TTS) in military personnel. Study Design A randomized control trial. Methods Two hundred and twenty‐four participants were enrolled. Nicergoline 30 mg twice daily intake was prescribed to the study group (n = 119) for 3 weeks. The placebo was prescribed to the control group (n = 105) for 3 weeks, as well. Audiometric thresholds were measured at baseline and within 24 h after the participants attended a 1‐day weapons firing practice. During the firing practice, all participants had to wear foam earplugs. The TTS was assessed by using a variety of published significant threshold shift (STS) definitions. Additionally, the effects of the treatment group on the magnitude of pre‐ to postexposure threshold shifts were estimated. Tinnitus and other adverse effects of the medication were recorded. Results The incidence of STS was 65.4% from the study group and 75% from the control group. The negative STS (thresholds improved) was 68.6% from the study group and 44.7% from the control group. The positive STS (thresholds worsened) from the study group and the control group was 31.4% and 55.3%, respectively. The effect of treatment in participants receiving nicergoline demonstrated significant coefficients (change in dB) in both ears (p = .001). The mean different threshold of participants receiving nicergoline showed negative STS in all tested frequencies without statistical significance. However, the mean different threshold of participants receiving a placebo showed positive STS with statistical significance. Additionally, there were 16 ears detecting a warning sign of permanent hearing loss. These participants from the control group presented a longer duration of tinnitus (p = .042). Moreover, the serious adverse effects of nicergoline were considerably low. Conclusion The study results suggest that nicergoline may attenuate noise‐related TTS and tinnitus, and justify further investigation on the effectiveness of this drug as an otoprotectant. Level of Evidence 2

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Nootropics: A Long Way in Half a Century

Sydorenko¹

2023

Act. Probl. of the Modern Med.

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Introduction. Currently, there are drugs that can improve cognitive processes. They are nootropics. The term "nootropics" was introduced in 1972, when piracetam's memory-enhancing properties were discovered, and this group of drugs has served the human benefit for half a century. The purpose of the work is to analyze known facts and new trends in the development of nootropics as a pharmacological group. Materials and methods. Internet resources (PubMed, Google Scholar, CrossRef) are used to search for information. Original research articles, meta-analyses and systematic reviews are included in the study. Attention was focused on providing an up-to-date overview of known means. Main part. For classification, the distribution of nootropics according to the mechanism of action is proposed. Nootropics have both a receptor mechanism of action and improve the supply of glucose and oxygen to the brain, the synthesis of proteins, nucleic acids and phospholipids, eliminate oxygen free radicals, have an antiplatelet effect, and optimize cerebral blood circulation. They are used for the treatment of psycho-organic syndrome. Nootropics are effective in providing benign senile disease, in children with minimal brain dysfunction syndrome, in case of encephalopathy and myalgic encephalomyelitis. Nootropics are indicated for patients with Alzheimer's disease, schizophrenia, hyperkinetic disorder. They are well tolerated. Their effectiveness depends on the dose, and after the disappearance of the disorder, the treatment should be continued for at least 2-3 weeks. Nootropics attract the attention of practically healthy individuals, in particular, students, but their use by healthy people is against concern due to the absence of clinical evidence of effectiveness, safety and social consequences. Some of the most famous nootropic drugs are piracetam, pyritinol, nicergoline, and vinpocetine, which have certain shades of pharmacodynamics, dosage, and side effects. Conclusions. Therefore, all nootropics improve cognitive function, especially in cases of the damage or degeneration, are well tolerated and should be prescribed by a specialist in each specific case. New research is needed to confirm or simplify the beneficial effects of nootropics in healthy individuals.

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A clinical trial of nicergoline to prevent temporary threshold shift

Cited by 3 publications

References 26 publications

Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs

Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs

A clinical trial of nicergoline to prevent temporary threshold shift

Nootropics: A Long Way in Half a Century

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