A Clinical Trial with Brazilian Arnica (<i>Solidago chilensis</i> Meyen) Glycolic Extract in the Treatment of Tendonitis of Flexor and Extensor Tendons of Wrist and Hand

Silva, Ary Gomes da; Machado, Elbe Rodrigues; Almeida, Leonardo Mendes de; Nunes, Ricardo Marcelo Menezes; Giesbrecht, Patrícia Caldeira Pena; Costa, Regina Mamed; Costa, Helber B.; Romão, Wanderson; Kuster, Ricardo Machado

doi:10.1002/ptr.5323

Cited by 12 publications

(5 citation statements)

References 30 publications

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“…Regarding the treatment group, this result could partly derive as a direct consequence of the reduction in muscle tension states induced by drugs; on the other hand, the beneficial effects of mesotherapy with associations of NSAIDs and muscle relaxants are now known in the literature [ 31 , 41 ]. This kind of association has also shown positive results in the treatment of other diseases.…”

Section: Discussionmentioning

confidence: 99%

Neck Pain in Fibromyalgia: Treatment with Exercise and Mesotherapy

et al. 2023

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Background and Objectives: Fibromyalgia is a very common musculoskeletal disease. The purpose of this study is to assess, on a population of fibromyalgic patients, the clinical efficacy of antalgic mesotherapy with diclofenac and thiocolchicoside in the treatment of cervical pain reduction for improvement of the functional capacity and quality of life of these patients. Materials and Methods: We conducted an observational study of 78 fibromyalgia patients recruited using our hospital database. Based on the different types of treatment received, the patients were divided into two groups: the treatment group (TG), who received antalgic mesotherapy with diclofenac, thiococolchicoside, and mepivacaina; and the placebo group (PG), who received mesotherapy with sodium chloride solution. Patients in both groups also received the same rehabilitation protocol of 20 sessions. The primary outcome evaluated was the extent of pain. The secondary outcomes were the functional capacity and quality of life. Results: Pain improved both in the treatment group (7.4 ± 1.2 vs. 5.1 ± 1.1; p < 0.05) and placebo group (7.5 ± 1.4 vs. 6.1 ± 1.6; p < 0.05). The treatment group, compared to the placebo group, also showed significant statistical improvements in functional capacity (NDI: 35.6 ± 5.23 vs. 19.3 ± 3.41; p < 0.05) and quality of life (SF-12: 18.3 ± 4.11 vs. 33.1 ± 2.41; p < 0.05). Conclusions: Mesotherapy treatment with diclofenac and thiocolchicoside is a safe and effective procedure in the management of neck pain in fibromyalgia patients in the short term in terms of pain reduction, functional recovery and quality of life.

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Section: Discussionmentioning

confidence: 99%

Neck Pain in Fibromyalgia: Treatment with Exercise and Mesotherapy

et al. 2023

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“…Treatment with Arnica alone or in combination with Arnica creams, for 6 and 12 days, reduced pain more efficiently compared to the control group [43]. The application of a gel cream containing 5% Solidago chilensis (a Brazilian Arnica extract) to the skin for 21 days reduced arm pain in patients suffering from tendinitis of the flexor and extensor tendons [44].…”

Section: Other Musculoskeletal Painmentioning

confidence: 99%

Clinical Trials, Potential Mechanisms, and Adverse Effects of Arnica as an Adjunct Medication for Pain Management

Smith

Miles

et al. 2021

Medicines

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Arnica has traditionally been used in treating numerous medical conditions, including inflammation and pain. This review aims to summarize the results of studies testing Arnica products for pain management under different conditions, including post-operation, arthritis, low back pain, and other types of musculoskeletal pain. Based on data from clinical trials, Arnica extract or gel/cream containing Arnica extract shows promising effects for pain relief. These medical benefits of Arnica may be attributed to its chemical components, with demonstrated anti-inflammatory, antioxidant, anti-microbial, and other biological activities. In conclusion, Arnica could be an adjunct therapeutical approach for acute and chronic pain management.

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“…Only one reference was found about an in vitro assay, where the ethanolic ether extract of its inflorescences decreased NO production in LPS-induced macrophage culture [95]. In addition, a reference was found using a semi-solid formulation (gel-cream) in a clinical study for cases of tendinitis in the flexor and extensor tendons of the wrist and hand [94].…”

Section: Solidago Chilensismentioning

confidence: 99%

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

Lopes

Oliveira²,

Viçosa³

et al. 2020

Planta Med

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Compositae is the largest family of flowering plants, with more than 1600 genera and 22 000 species. It has many economic uses in foods, cosmetics, and pharmaceutics. The literature reports its numerous medicinal benefits and recognized anti-inflammatory activity. Thus, this study evaluated the technological trends of anti-inflammatory activity of Compositae, based on the survey of scientific databases, articles, and patents, as well as the website of the Brazilian National Health Regulatory Agency (ANVISA), which is responsible for registering and controlling of healthcare and cosmetic products in the Brazil. The survey was conducted between 2008 and 2018, in the databases Science Direct, Lilacs, PubMed, and Web of Science (main collection), as well as the SciELO Citation Index. The patent survey was carried out on the basis of the Derwent Innovations Index, an important source for worldwide patent consultation, which covers 20 y of registered patents. Despite the numerous studies involving species of the Compositae family in different models of anti-inflammatory activity, there are few records of patents or products on the market from these species for that purpose. Some species have a traditional use and are present even in the Phytotherapic Summary of the Brazilian Pharmacopeia. This review confirms the therapeutic potential of Compositae for the development of anti-inflammatory drugs and reinforces the need to develop competencies and reduce technological bottlenecks to promote research and innovation in biodiversity products.

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A Clinical Trial with Brazilian Arnica (Solidago chilensis Meyen) Glycolic Extract in the Treatment of Tendonitis of Flexor and Extensor Tendons of Wrist and Hand

Cited by 12 publications

References 30 publications

Neck Pain in Fibromyalgia: Treatment with Exercise and Mesotherapy

Neck Pain in Fibromyalgia: Treatment with Exercise and Mesotherapy

Clinical Trials, Potential Mechanisms, and Adverse Effects of Arnica as an Adjunct Medication for Pain Management

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

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