A clinicohematological evaluation of pancytopenia in a tertiary care hospital in South India

Graham, Shane; Marla, Nisha J; Fernandes, Hilda; Jayaprakash, CS

doi:10.4103/0975-9727.146410

Cited by 5 publications

(7 citation statements)

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“…The mean age of the enrolled patients was 37 years (range: 3-80 years). The prevalence of the 31-45 years age group (25%) and 16-30 years age group (27%) aligned with the outcomes of Graham et al 5 and Azaad et al 6 The pancytopenia prevalence in terms of malefemale ratio (1:1.25), the incidence in males (44%), and incidence in females (56%) matched the findings of Pathak et al (1:1.04) 7 and Aziz et al (1:1.43); 8 however, these outcomes were contradicted by the results of Gayathri et al 9 indicating a high incidence of males. The incidences of symptoms revealed by this cross-sectional study [i.e., pallor (100%), breathlessness (27%), fever (59%), and generalized weakness (82%)] concorded with the outcomes of Raina et al 10 and Gayathri et al 9 Similarly the findings of Gayathri et al 9 matched our results concerning variations in platelet count (12000-99000/µL), total leukocyte count (600-3800/µL), and hemoglobin levels (2.5-9.8gm%).…”

Section: Discussionsupporting

confidence: 78%

Clinical and hematological evaluation of pancytopenia: A cross-sectional study in a tertiary care center in Western Odisha

Nayak,

Sahu,

Mishra

et al. 2023

PJMS

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Pancytopenia is the outcome of bone marrow abnormalities and progresses with thrombocytopenia, leukopenia, and anemia. The frequently reported clinical manifestations of pancytopenia include infections, hemorrhage, dyspnea, and pallor. This study aimed to improve the diagnostic assessment of pancytopenia by underlying its potential hematological and clinical parameters. The enrolled patients underwent hematological and clinical assessments for pancytopenia at Veer Surendra Sai Institute of Medical Science and Research, Odisha, India. The pancytopenia assessment parameters included peripheral blood smear, reticulocyte count, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, mean corpuscular volume, differential count, total platelet count, total leukocyte count, red blood cell count, and hemoglobin level. Patients also underwent bone marrow aspiration and biopsy for diagnostic investigation.The bone marrow study and peripheral smears were conducted on eighty-eight patients, and findings revealed the incidence of potential pancytopenia causes including, malaria (1%, n=1), multiple myeloma (1%, n=1), metastatic adenocarcinoma (1%, n=1), hemophagocytic lymphohistiocytosis (1%, n=1), tubercular granuloma (1%, n=1), sickle cell crisis (2%, n=2), hypersplenism (3%, n=3), myelodysplastic syndromes (3%, n=3), acute lymphoblastic leukemia (3%, n=3), acute myeloid leukemia (7%, n=6), aplastic anemia (32%, n=28) and megaloblastic anemia (43% n=38). Pancytopenia is predominantly caused by megaloblastic anemia and aplastic anemia, respectively. The frequently reported clinical manifestations include bleeding, fever, and weakness. The diagnostic affirmations rely on bone marrow biopsy/aspiration.

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Section: Discussionsupporting

confidence: 78%

Clinical and hematological evaluation of pancytopenia: A cross-sectional study in a tertiary care center in Western Odisha

Nayak,

Sahu,

Mishra

et al. 2023

PJMS

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“…The variation of incidence of megaloblastic anemia depends on the status of the nutritional anemia in that particular region of the study. [24] All cases in our study showed low levels of serum vitamin B12.…”

Section: Causes Of Pancytopeniamentioning

confidence: 50%

“…Few studies have also reported low incidence of aplastic anemia. [1]& [24] Bone marrow aspiration showed hypoplastic marrow.…”

Section: Annals Of Pathology and Laboratory Medicine Vol 5 Issue 2mentioning

confidence: 99%

Clinico-hematological analysis of pancytopenia in adults – A two year prospective study

Patel¹,

Tambekar

Dhar

2018

APALM

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Clinico-hematological Analysis of Pancytopenia in Adults-A Two Year Prospective Study EDTA anticoagulated blood (2ml) was collected, processed through automated 5part differential cell analyzer and hematological parameters were obtained. Peripheral blood smear was stained with Field's and Leishman stain and examined for RBC, WBC and platelet morphology along with hemoparasites. Anemias were classified morphologically as normocytic normochromic, microcytic hypochromic, macrocytic & dimorphic anemia. Informed consent was taken before performing bone marrow aspiration in cases where it was required. Special tests: Rapid malarial antigen test, dengue card test, leptospirosis card test, tests for HIV, Hepatitis viruses, serum vitamin B12, serum iron studies, liver and renal function tests and tests for tuberculosis, USG abdomen, CT and MRI scans, PET scans, etc. were also performed.

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“…Graham et al, found erythroid hyperplasia in 9 (30%) cases and it was the most common cause of pancytopenia in their study of 30 cases who presented as pancytopenia. 13 Lakhey et al, and Jha et al, also found 6 (11.11%) cases and 29 (19.6%) cases of erythroid hyperplasia in their study of pancytopenia. 10,14 Same studies from Nepal also showed 4 (7.41%) cases and 5 (3.38%) cases of normal marrow in their studies.…”

Section: Discussionmentioning

confidence: 84%

“…11 Different studies showed different causes of Pancytopenia. According to the study done by Mir et al, 3 megaloblastic anaemia was 72.7% and acute leukaemia 6.8%, by Rehmani et al, 4 20% megaloblastic anemia and 27.05% aplastic anemia, by Gayathri et al, 6 Megaloblastic Anaemia 74% and Aplastic Anaemia 18%, by Vaiday S, 7 Megaloblastic anemia 34.95%, Aplastic anemia 31.33%, by Pereira ADS et al, 8 Megaloblastic anemia (60%), Aplastic anemia and leukemia (10% each), by R Pathak et al, 9 Hypoplastic anemia (42.15%) and Hematological malignancies (19.4%), by Lakhey et al, 10 Hypoplastic anemia (29.6%) and Hematological malignancies (27.78%), by Khodke K et al, 11 Megaloblastic anaemia (44) and Aplastic anaemia (14), by Graham S et al, 13 Normoblastic erythroid hyperplasia (30%), Megaloblastic anemia (20%), by Jha et al, 14 Hypoplastic anemia (29.05%) and Megaloblastic anemia (23.64%). Present study shows Hypoplastic anemia (27.5%) and Megaloblastic anemia (18.8%).…”

Section: Discussionmentioning

confidence: 99%

Clinicohematological Study of Pancytopenia in a Tertiary Care Hospital of Western Region of Nepal

et al. 2017

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Introduction: Pancytopenia is a relatively common hematological entity and is a manifestation of many illnesses which can be life threatening at times. The severity of pancytopenia and the underlying pathology determine the management and prognosis. This study was conducted to evaluate hematological and bone marrow findings in patients presenting with pancytopenia. Methods: It was a prospective study carried out in Department of Pathology, Manipal College of Medical Sciences, Pokhara, Nepal, during the period of January 2011 to December 2016. Clinical and hematological parameters including bone marrow aspiration and biopsy were evaluated in all patients who presented with pancytopenia. Results: Among 138 cases studied, patient’s age ranged from 2 to 82 years with a mean age of 43.95 years, and there was male predominance. Most of the patients presented with generalized weakness, pallor, dypnoea and fever. Hypoplastic marrow was seen in 38(27.5%) cases, followed by megaloblastic anemia 26 (18.8%) cases and acute leukemia 19(13.76%) cases. Other findings included one each case of hemophagocyosis, leishmaniasis, plasmodium vivex malaria and metastatic carcinoma. Conclusions: This study highlights that pancytopenia is a common hematological problem and the study of detailed primary hematological investigations along with bone marrow study in patients with pancytopenia will help to identify the cause for further planning and management. Keywords: hypoplastic marrow; leukemia; megaloblastic anemia; pancytopenia.

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A clinicohematological evaluation of pancytopenia in a tertiary care hospital in South India

Cited by 5 publications

References 0 publications

Clinical and hematological evaluation of pancytopenia: A cross-sectional study in a tertiary care center in Western Odisha

Clinical and hematological evaluation of pancytopenia: A cross-sectional study in a tertiary care center in Western Odisha

Clinico-hematological analysis of pancytopenia in adults – A two year prospective study

Clinicohematological Study of Pancytopenia in a Tertiary Care Hospital of Western Region of Nepal

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