Clinico-hematological analysis of pancytopenia in adults – A two year prospective study

Patel, R. D.; Tambekar, Manisha; Dhar, Reeta

doi:10.21276/apalm.1519

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…[6] Patel et al observed that the age of the patients ranged from 15-85 years with male preponderance. [7] Momin et al noted that the age of patients ranged from 2 to 85 years with a mean age of 43 years.…”

Section: Discussionmentioning

confidence: 99%

“…[6] Patel et al observed that the most common clinical features were weakness (80%), fever (72.1%), pallor (100%) and hepatomegaly (62.8%). [7] Momin et al noted that fever and generalized weakness were common clinical presentations. The commonest physical finding was pallor and splenomegaly on systemic examination.…”

Section: Discussionmentioning

confidence: 99%

“…[6] Normocytic normochromic was the predominant blood picture in the study done by Patel et al who found that common causes of pancytopenia were malaria (50%), megaloblastic anemia (18.6%) and dengue (18.1%) followed by hypersplenism (7.1%) & iron deficiency anemia(2.7%). [7] Momin et al found that the commonest peripheral smear was dimorphic picture & commonest bone marrow finding was hypercellular marrow with megaloblastic erythroid hyperplasia. The commonest cause for pancytopenia was Megaloblastic anemia (34%) followed by Hematolymphoid malignancy (26.6%).…”

Section: Discussionmentioning

confidence: 99%

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Clinico-Hematological Study of Pancytopenia in Adults at a Tertiary Care Center

Vaibhaw¹,

Girikumar²,

Mandke³

et al. 2019

AJMR

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Background: Pancytopenia is one of the important haematological derangements. Thorough investigation for ascertaining the cause is important. Subjects and Methods: The present cross-sectional study was conducted upon 112 patients of pancytopenia. Profile of the patients, clinical features and findings of haematological investigations and bone marrow aspiration were noted. Results: Mean age of the patients was 46.7 ± 9.3 years. Pallor was seen in all the patients. Megaloblastic anemia was present in 36.6%, acute leukemia in 11.6%, hypersplenism and lymphoprofilerative disorder each in 10.7%. Conclusion: Hematological investigations and bone marrow aspiration in patients suffering from pancytopenia is useful.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinico-Hematological Study of Pancytopenia in Adults at a Tertiary Care Center

Vaibhaw¹,

Girikumar²,

Mandke³

et al. 2019

AJMR

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A Study of Clinical, Hematological and Biochemical Profiles of Patients with Pancytopenia

Srivastava,

Verma,

Ashraf

et al. 2024

Indian Journal of Clinical Medicine

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This study aimed to investigate patients’ clinical, hematologic, and biochemical profiles with pancytopenia. This prospective observational study was conducted at a tertiary care hospital from January 2019 to June 2020 on 80 patients, 39 (48.7%) were males and 41 (51.2%) were females, over the age of 18 presenting with pancytopenia. All the patients were subjected to thorough clinical and physical examinations. A complete blood count (CBC), peripheral smear examination, bone marrow aspiration, and reticulocyte count were performed. The data was analyzed using the IBM SPSS 20.0 software. Most of the cases had moderate (Hb<7-9.9g/dl) anemia (63.7%, 51/80 cases), while severe anemia (<7g/dl) was seen in 31.2% (25/80) cases, and 5% (04/80) cases showed mild anemia (Hb<10-11.9g/dl). Most patients with severe anemia had vitamin B12 deficiency anemia (12/80), that is, 15%. Macrocytic anemia was noted in preponderance (50% cases, 40/80), whereas microcytic hypochromic and normocytic hypochromic anemia constituted 21.3% (17/80), and dimorphic anemia was seen in 7.5% (06/80) cases. Based on WBC counts, 56.3% of cases (45/80) showed counts between 2000 and 4000 cells/cu.mm, while counts between 1000 and 2000 cells/cu.mm were seen in 31.3% of cases (25/80), and 12.5% of cases (10/80) had counts of <1000 cells/cu.mm. The study highlighted that 28.8% (23/80) had a platelet count between 50,000 and 1 lakh/cu.mm (mild thrombocytopenia), 36.3% (29/80) cases had a platelet count between 20,000 and 50,000/cu.mm (moderate thrombocytopenia), and 35% (28/80) cases had a platelet count less than 20,000/cu.mm (severe thrombocytopenia). The most common diagnosis of bone marrow aspiration was megaloblastic anemia, seen in 50.0% (6/12) cases. Megaloblasts were seen in 50.0% (6/12) cases of megaloblast anemia. The bone marrow aspirate of a patient with dengue fever and malaria showed macrophages containing engulfed red blood cells, lymphocytes, and platelets. Myeloblasts (>20%) were seen in 1 (8.3%) case of AML, and decreased myelopoiesis was seen in 25% of cases (two cases of aplastic anemia and one case of MDS). This study concludes that vitamin B12 deficiency is the most common cause, which is more common in people who are strict vegetarians, with a predominance in the younger age group. The study also emphasized the vitality of the physical findings, detailed primary hematologic and biochemical investigations, and peripheral blood pictures, all of which provide precious information in the work-up of pancytopenia patients.

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Assessment of the Clinic-pathological Profile of Patients with Pancytopenia

Tiwari,

Kaushal,

Chowdhary

et al. 2023

Acta Medica International

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Introduction: Pancytopenia is an important clinico-hematological condition encountered in day-to-day clinical practice. Pancytopenia is often very difficult to diagnose and treat often owing to its varied aetiologies, causes might ranging from infections, nutritional deficiencies to malignancies. Materials and Methods: This was a cross-sectional study conducted in Department of General Medicine, Rohilkhand Medical College and Hospital, Bareilly. Patients’ information was filled in pro forma, and contains patient’s age, gender, clinical features, clinical findings, CBC findings, bone marrow findings, and diagnosis from all patients collected. Detailed clinical history and clinical examination along with blood investigation were carried out. Results: In the present study, the mean level of platelets was 54,000 ± 31,549/µL, with a minimum level of 2000/µL and a maximum level of 130,000/µL, indicating that majority of patients suffered from thrombocytopenia. The mean level of white blood cells (WBCs) was 2873.4 ± 780.4/µL, with a minimum level of 1000/µL and a maximum level of 3860/µL, indicating that all the patients suffered from leukopenia. 30% of patients had normocytic normochromic RBC, 24% had macrocytic normochromic RBC, 22% had macrocytic hyperchromic, 6% had microcytic normochromic, 8% had microcytic hypochromic, and 10% had both macrocytic and microcytic RBCs. Conclusion: Mean values of Hb, WBC & Platelet count was non-significantly higher among female patients comparing to males, though mean value of MCV was non-significantly higher in male patients comparing to females.

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Clinico-hematological analysis of pancytopenia in adults – A two year prospective study

Cited by 3 publications

References 5 publications

Clinico-Hematological Study of Pancytopenia in Adults at a Tertiary Care Center

Clinico-Hematological Study of Pancytopenia in Adults at a Tertiary Care Center

A Study of Clinical, Hematological and Biochemical Profiles of Patients with Pancytopenia

Assessment of the Clinic-pathological Profile of Patients with Pancytopenia

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