A Combination of Prebiotic Inulin and Oligofructose Improve Some of Cardiovascular Disease Risk Factors in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial

Aliasgharzadeh, Akbar; Khalili, Mohammad; Mirtaheri, Elham; Gargari, Bahram Pourghassem; Tavakoli, Farnaz; Farhangi, Mahdieh Abbasalizad; Babaei, Hossein; Dehghan, Parvin

doi:10.15171/apb.2015.069

Cited by 72 publications

(50 citation statements)

References 31 publications

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“…Aliasgharzadeh et al showed that supplementation with oligofructose-enriched inulin for 8 weeks in diabetic patients significantly decreased body weight, body mass index, fasting plasma glucose, fasting plasma glucose, HbA1c, TC (total cholesterol), LDL-c , TC (total cholesterol) / HDL-c ratio, LDL-c / HDL-c ratio, LDL-c / HDL-c ratio and MDA (malondialdehyde), however, we could find no significant effect on TG (triglycerides), SOD (superoxide dismutase), GSH-Px (glutathione peroxidase) and catalase compared to the placebo group [44][45][46][47][48][49][50][51].…”

Section: Effects Function and Mechanism Of Action Of Prebioticscontrasting

confidence: 74%

Symbiotic Gels: Alternative in Renal Insufficiency

Mv¹

2017

J Fam Med

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Probiotics are microorganisms that provide a positive effect on the host where Lactobacillus and Bifidobacteruim are the most frequent species in this group; on the other hand prebiotics are substances that provide a selective stimulation of growth to species beneficial to humans such as those mentioned above, where inulin or oligofructose are the most representative substances in this category. The intestinal flora represents a great variety of microorganisms such as Bacteroides, Faecalibacterium, Bifidobacterium among others, maintaining a homeostasis in its environment, however in patients with chronic renal failure (CKD) show an increase in the intestinal level of aerobic bacteria such as Firmicutes, Actinobacteria and Proteobacteria resulting in an increase of metabolites such as phenols, indoles and amines that contribute to uremic toxicity. It is known that the use of probiotics and prebiotics have many applications in the medical field, from cardiovascular diseases, diarrhea, allergies, Helicobacter pylori erradication, nephropathies to use in cancer patients. The increase in the number of patients with chronic renal failure) and the mechanisms of action by these microorganisms could represent an alternative in these patients. However, the scientific evidence in this area is limited, which represents an area of opportunity. Through the analysis, we intend to present scientific evidence in the use of probiotics (lactobacillus rhamnosus NH001, Bifidobacteriumlactis Bi07) and prebiotics (blue agave inulin) as an alternative treatment in patients with renal failure for the significant decrease in toxin levels.

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Section: Effects Function and Mechanism Of Action Of Prebioticscontrasting

confidence: 74%

Symbiotic Gels: Alternative in Renal Insufficiency

Mv¹

2017

J Fam Med

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“…Chicory inulin is also considered as a prebiotic because of its ability to stimulate the proliferation of beneficial microorganisms in the gut , and this property may potentially improve insulin resistance in patients with T2DM . Moreover, clinical evidences have shown that inulin exhibits anti‐inflammatory, antioxidant and cyto‐protective activities in T2DM patients . In addition, inulin could ameliorate metabolic disorders in fat‐supplemented diet rats and female diabetic patients .…”

Section: Introductionmentioning

confidence: 99%

Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro

Ning

Wang²,

Gao

et al. 2017

Molecular Nutrition Food Res

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“…1,2 Due to the presence of vitamins, minerals, fiber, prebiotic and antioxidants in fruits and vegetables, they are frequently used for improving lipid profile disorders and oxidative stress, protecting against chronic diseases such as cardiovascular disease, diabetes and many types of cancers as well as other malignancies. 1,[3][4][5] Food contamination with food-borne pathogens and toxin is an emerging public health hazard that is considered as current context of food safety in Iran. 6 It seems that providing safe and healthy ready-to-eat vegetable salads (REVS) could be a good strategy for protection against these diseases.…”

Section: Introductionmentioning

confidence: 99%