A Comparative Study of the Effect of Gastric Bypass, Sleeve Gastrectomy, and Duodenal–Jejunal Bypass on Type-2 Diabetes in non-Obese Rats

Xu, Bo; Yan, Xiao‐Jie; Shao, Yikai; Shen, Qiwei; Hua, Rong; Ding, Rui; Yao, Qiyuan

doi:10.1007/s11695-015-1835-z

Cited by 12 publications

(5 citation statements)

References 43 publications

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“…Because bariatric surgery is overwhelmingly prescribed for clinically obese subjects, the literature on the impact of bariatric surgery in non-obese is limited. One study in non-obese rats demonstrated significant weight loss after RYGB and VSG (Xu et al, 2015). In contrast, a recent study showed that RYGB did not cause sustained weight loss in the non-obese mouse (Mumphrey et al, 2019).…”

Section: Indiscriminate Weight-loss In the Non-obesementioning

confidence: 94%

The Phantom Satiation Hypothesis of Bariatric Surgery

Gautron

2021

Front. Neurosci.

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The excitation of vagal mechanoreceptors located in the stomach wall directly contributes to satiation. Thus, a loss of gastric innervation would normally be expected to result in abrogated satiation, hyperphagia, and unwanted weight gain. While Roux-en-Y-gastric bypass (RYGB) inevitably results in gastric denervation, paradoxically, bypassed subjects continue to experience satiation. Inspired by the literature in neurology on phantom limbs, I propose a new hypothesis in which damage to the stomach innervation during RYGB, including its vagal supply, leads to large-scale maladaptive changes in viscerosensory nerves and connected brain circuits. As a result, satiation may continue to arise, sometimes at exaggerated levels, even in subjects with a denervated or truncated stomach. The same maladaptive changes may also contribute to dysautonomia, unexplained pain, and new emotional responses to eating. I further revisit the metabolic benefits of bariatric surgery, with an emphasis on RYGB, in the light of this phantom satiation hypothesis.

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Section: Indiscriminate Weight-loss In the Non-obesementioning

confidence: 94%

The Phantom Satiation Hypothesis of Bariatric Surgery

Gautron

2021

Front. Neurosci.

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“…GIP activates GLP-1 [33,34], and GLP acts on receptors located in pancreatic β cells, inhibiting glucagon secretion, thereby resulting in glucose-dependent insulin secretion [35]. The improved capacity for insulin secretion after bariatric surgery may also be associated with inhibition of apoptosis of β cells in pancreatic islets or tissue repair [36].…”

Section: Diabetes Remissionmentioning

confidence: 99%

The Long-Term Effects of Bariatric Surgery on Type 2 Diabetes Remission, Microvascular and Macrovascular Complications, and Mortality: a Systematic Review and Meta-Analysis

et al. 2017

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This systematic review aimed to evaluate the long-term (≥ 5 years) outcomes of bariatric surgery on diabetes remission, microvascular and macrovascular events, and mortality among type 2 diabetes (T2D) patients. Ten articles (one randomized controlled trial and nine cohorts) met the inclusion criteria and were included in this review. Pooled estimates of nine cohort studies showed that surgery significantly increased the diabetes remission (relative risk (RR) = 5.90; 95% CI 3.75-9.28), reduced the microvascular (RR = 0.37; 95% CI = 0.30-0.46) and macrovascular events (RR = 0.52; 95% CI 0.44-0.61), and mortality (RR = 0.21; 95% CI 0.20-0.21) as compared to non-surgical treatment. Available evidence suggests better remission and lower risks of microvascular and macrovascular disease and mortality in the surgery group as compared to non-surgical treatment group in T2D patients after at least 5 years of follow-up.

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“…Because the db/db mice were executed at 2 weeks after surgery for a further study, long-term weight change wasn’t followed up. Based on this phenomenon, we speculated that it was an incipient consequence conducted by surgery [ 20 ] or different species or genetic background have distinct responses to DJB surgery.…”

Section: Discussionmentioning

confidence: 99%

“…The abdominal was irrigated with saline and the wound was closed with 5-0 silk thread. 10% cefoxitin solution was injected via intraperitoneal [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Duodenal-Jejunal Bypass Surgery Reverses Diabetic Phenotype and Reduces Obesity in Mice

Liang

Wang

Qiao

et al. 2017

Curr. Chem. Genomics and Translat. Med.

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Type 2 diabetes mellitus (T2DM), a complex metabolic disorder typically accompanying weight gain, is associated with progressive β-cell failure and insulin resistance. Bariatric surgery ameliorates glucose tolerance and provides a near-perfect treatment. Duodenal-jejunal bypass (DJB) is an experimental procedure and has been studied in several rat models, but its influence in db/db mice, a transgenic model of T2DM, remains unclear. To investigate the effectiveness of DJB in db/db mice, we performed the surgery and evaluated metabolism improvement. Results showed that mice in DJB group weighed remarkably less than sham group two weeks after surgery. Compared to the preoperative level, postoperative fasting blood glucose (FBG) was dramatically reduced. Statistical analysis revealed that changes in body weight and FBG were significantly correlated. Besides, DJB surgery altered plasma insulin level with approximate 40% reduction. Thus, for the first time we proved that DJB can achieve rapid therapeutic effect in transgenic db/db mice with severe T2DM as well as obesity. In addition, decreased insulin level reflected better insulin sensitivity induced by DJB. In conclusion, our study demonstrates that DJB surgery may be a potentially effective way to treat obesity-associated T2DM.

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A Comparative Study of the Effect of Gastric Bypass, Sleeve Gastrectomy, and Duodenal–Jejunal Bypass on Type-2 Diabetes in non-Obese Rats

Abstract: The three surgical methods described alleviated T2DM and reduced insulin resistance in non-obese rats with T2DM.

Cited by 12 publications

References 43 publications

The Phantom Satiation Hypothesis of Bariatric Surgery

The Phantom Satiation Hypothesis of Bariatric Surgery

The Long-Term Effects of Bariatric Surgery on Type 2 Diabetes Remission, Microvascular and Macrovascular Complications, and Mortality: a Systematic Review and Meta-Analysis

Duodenal-Jejunal Bypass Surgery Reverses Diabetic Phenotype and Reduces Obesity in Mice

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