A Comparative Survey of Leguminous Plants as Sources of the Isoflavones, Genistein and Daidzein: Implications for Human Nutrition and Health

Kaufman, Peter B.; Düke, James A.; Brielmann, Harry; Boik, John C.; Hoyt, James E.

doi:10.1089/acm.1997.3.7

Cited by 264 publications

(167 citation statements)

References 12 publications

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“…Given the important role of lipids in brain function [2][3][4], the results of this study are consistent with the positive effect of soybean on the cognitive ability of rats at adulthood [6]. Another reason, no doubt, is the effect of isoflavo-noids contained in soybeans in significant amounts [16], but the complexity of determining their trace amounts in animal tissues does not allow us today to discuss this mechanism.…”

supporting

confidence: 67%

The Influence of the Treatment of Rats Within a Life With Enriched Soya Diet on Lipids of Blood, Liver and Brain

Feoktistova¹,

Shtarberg²,

Borodin³

2017

AMJ

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: Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women. Am. J. Clin. Nutr. 78,[123][124][125][126][127][128][129][130]. West SG, Hilpert KF, Juturu V et al. (2005): Effects of including soy protein in a blood cholesterol-lowering diet on markers of cardiac risk in men and in postmenopausal women with and without hormone replacement therapy. J. Womens Health (Larchmt). 14(3), 253-262. 8. Eugene A. Borodin, Iraida G. Menshikova, Vladimir A. Dorovskikh, Natalya A. Feoktistova et al. (2009 We present the results of the study of the effect of long-term soy intake on the content of some lipids and products of their oxidative modification in the blood, liver and brain of rats, and attempts are made to use them to explain the ability of soya that we have es-tablished to prevent a decrease in the cognitive abilities of rats in adulthood growth [6].The study was performed on white laboratory rats (18 males and 24 females). The animals of the control group received a standard diet, and the experimental three days a week the standard di-et, and four days boiled soya. A detailed description of the conditions of feeding of rats was de-scribed earlier [6]. The animals were removed from the experiment at the age of 15 month. Blood plasma, erythrocyte mass, liver and brain tissue were analyzed. Biochemical parameters of blood plasma were determined with the help of standard reagent sets on the biochemical semi-automatic analyzer Stat Fax 1904+. Lipids were extracted from the erythrocyte mass, liver and brain samples of the rats using Folch method [12]. In the lipid extracts, the content of total lipids was determined gravimetrically, cholesterol, phospholipids, diene conjugates and hydroperoxides with color reac-tions [1]. UV absorption spectra of lipid extracts were recorded on a UNICO 2804 spectrophotome-ter [9]. The fatty acid composition of brain lipids in the combined extracts of the control and exper-imental groups of rats was studied by gas-liquid chromatography of methyl esters of fatty acids on the gas-liquid chromatogram Crystal 2000M, column DB-23, carrier gas-purity 0.9999. Chromato-gram analysis was performed using the Chromatec Analytic 2.5 program [5].Feeding rats with large quantities of soy for a lifetime did not affect the rates depending on the nature of the diet, and the animals receiving the enriched diet did not differ in the content of total protein, glucose, cholesterol, triglycerides, and activity of alanine aminotransferase ( ALAT) in the blood plasma with vivo-control group. The sex of the animals did not matter.There were no differences in the content of total lipids, cholesterol, phospholipids and vitamin E in erythrocytes, depending on the sex of the animals. The only changes in the lipid composition and oxidation state of the erythrocyte lipids in the experimental and control group included a mod-erate increase in cholesterol by 28% and a decrease in the content of diene conjugates also by ...

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supporting

confidence: 67%

The Influence of the Treatment of Rats Within a Life With Enriched Soya Diet on Lipids of Blood, Liver and Brain

Feoktistova¹,

Shtarberg²,

Borodin³

2017

AMJ

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“…For instance, in flavonoid class, flavonols, flavones, flavanones, isoflavones, flavanols and anthocyanins are widely present in onions, parsley, citrus fruits, leguminous plants, green tea and blackberry, respectively ( Fig. 8) (Majewska et al, 2011;Holden et al, 2005;Kaufman et al, 1997).…”

Section: Dietary Metabotypes 31 Metabotypes Based On Occurrence Of Mmentioning

confidence: 99%

“…(Bell et al, 1991;Bollard et al, 2001;Duncan et al, 2007 ;Holmes et al, 2008). In nutrition, different metabotypes can be correlated to different diets; secondary metabolites, particularly produced by plants, represent strong biomarkers of consumed fruits, herbals and legumes (Kaufman et al, 1997;Yanez, 2008). In clinical field, different metabotypes can be indicator of different disease types, intoxication levels or doping sources (Timbrell, 1998;Kintz et al, 1999;Barderas et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Metabotype Concept: Flexibility, Usefulness and Meaning in Different Biological Populations

Semmar¹

2012

Metabolomics

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“…Genistein is biosynthetic compound one of the simplest flavonoid form of the leguminosae [13]. It expresses a broad spectrum of pharmacological activities, such as antioxidant, anticancer, and antimicrobial [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Acetylcholinesterase Inhibitory Effect of 3-(1h-Indol-3-Yl)-1, 3-Diphenylpropan-1-One Derivatives

Manjunatha

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of the study is acetylcholinesterase (AChE) inhibitory effect of 3-(1H-indol-3-yl)-1, 3-diphenylpropan-1-one derivatives by Ellman's method, physostigmine is used as positive control.Method: 3-(1H-indol-3-yl)-1, 3-diphenylpropan-1-one derivatives were synthesized by the addition of chalcone (0.25 g, 1 mmol), indole (0.12 g, 1 mmol) in ethanol (5 ml), and concentrated hydrochloric acid (5 mmol %). These earlier synthesized compounds were screened for AChE inhibitors by modifying Ellman's method.Results: Among the tested compounds, 3a and 3j were found to be having more potential than other compounds with half maximal inhibitory concentration values of 13.64 and 14.3 µg/ml, respectively. Whereas, compounds 3c, 3e, 3g, and 3i exhibited an average AChE inhibition of 16.4, 17.9, 17.6, and 21.1 µg/ml, respectively. Conclusion:The compounds 3-(1H-indol-3-yl)-1, 3-diphenylpropan-1-one derivatives were found to be possible lead molecules in AChE inhibition and even though, the molecules were structurally dissimilar to that of the standard, still they exhibited a considerable degree of inhibition and encourage the researchers to look into the mode of action of their inhibition ability against AChE.

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A Comparative Survey of Leguminous Plants as Sources of the Isoflavones, Genistein and Daidzein: Implications for Human Nutrition and Health

Cited by 264 publications

References 12 publications

The Influence of the Treatment of Rats Within a Life With Enriched Soya Diet on Lipids of Blood, Liver and Brain

The Influence of the Treatment of Rats Within a Life With Enriched Soya Diet on Lipids of Blood, Liver and Brain

Metabotype Concept: Flexibility, Usefulness and Meaning in Different Biological Populations

Acetylcholinesterase Inhibitory Effect of 3-(1h-Indol-3-Yl)-1, 3-Diphenylpropan-1-One Derivatives

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