A comparative virological study of children in hospital with respiratory and diarrhoeal illnesses

Stott, E. J.; Bell, Eleanor J.; Eadie, M. B.; Ross, Constance A. C.; Grist, N. R.

doi:10.1017/s0022172400045484

Cited by 19 publications

(6 citation statements)

References 28 publications

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“…We have examined stools from babies with enteritis admitted to one ward in one hospital over a period of 16 months. The purpose was to establish what viruses, bacteria and protozoa were excreted by these babies and our findings suggest that, as others have found by cell culture methods (Bell & Grist, 1967;Stott et at. 1967), excretion of viruses in young children does not directly parallel symptoms, and that to regard even rotaviruses as inevitable pathogens may be too simple a view.…”

Section: Introductionsupporting

confidence: 66%

Stool viruses in babies in Glasgow: 1. Hospital admissions with diarrhoea

Madeley

Cosgrove²,

Bell³

et al. 1977

J. Hyg.

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Stools from 183 babies under 2 years of age admitted to Ruchill Hospital with diarrhoea were examined by electron microscopy, virus culture, bacterial culture and light microscopy. As far as possible, several stools were examined from each patient and the results showed rotaviruses, astroviruses and other viruses in association with symptoms, as well as the expected bacterial pathogens. Examination of several stools from the same patient also showed that in this age group the viral flora of the gut changes rapidly and that the viruses seen by electron microscopy were only rarely grown in cell culture and vice versa. This phenomenon was particularly noted with adenoviruses. In 30% of cases no microbial pathogen was identified and in the remainder the presence of the infecting organism did not always coincide with the symptoms. It is concluded that, with viruses at least, presence of the organism does not constitute proof of causation.

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Section: Introductionsupporting

confidence: 66%

Stool viruses in babies in Glasgow: 1. Hospital admissions with diarrhoea

Madeley

Cosgrove²,

Bell³

et al. 1977

J. Hyg.

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“…Except in the neonatal period, rotavirus is rarely identified in the stools of asymptomatic children (Albrey and Murphy, 1976;Totterdell et al, 1976;Gust et al, 1977;Murphy et al, 1977) but the same is not true of other stool viruses (Stott et al, 1967;Flewett et al, 1974;Flewett, 1976;Madeley et al, 1977). This study did not include a group with no diarrhoea but it was conducted concurrently with a study of viruses isolated from children of the same age who were admitted with febrile convulsions (Lewis et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

A year's experience of the rotavirus syndrome and its association with respiratory illness.

Lewis¹,

Parry²,

Davies³

et al. 1979

Archives of Disease in Childhood

101

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SUMMARY In a hospital study rotavirus was identified in 51 % of 152 children with diarrhoea. These patients showed a clinical pattern that was distinct from patients in whom the diarrhoea was associated with bacteria, other viruses, or no pathogens. A respiratory illness was described in 66 % of rotavirus patients and usually preceded the gastrointestinal symptoms. Vomiting lasted between one and 3 days and was curtailed by substituting the normal diet with clear fluids. Watery diarrhoea continued for 4 or 5 days, even when rehydration was by the intravenous rather than the oral route. Prolonged diarrhoea was rare. Most children infected with rotavirus were under 2 years of age, but dehydration was most severe in infants aged between 12 and 18 months. A clinician can thus recognise the rotavirus syndrome and expect spontaneous recovery if adequate rehydration is maintained for a critical few days.

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“…Rhinoviruses have been known for sometime to infect the upper respiratory tract (Tyrrell et al 1960). Though Portnoy, Eckert & Salvatore (1965) suggested rhinoviruses were of no aetiological significance in lower respiratory disease of childhood, Hilleman, Reilly, Stokes & Hamparian (1963) found that 'coryza viruses' (rhinoviruses) were associated with lower respiratory tract infection in a third of a small number of children investigated, and Stott et al (1967) found rhinoviruses in 7 % of children with acute lower respiratory infections. In this series, three rhinoviruses were isolated from NP secretions, but only two from CN swabs ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

A comparative study of methods for the diagnosis of respiratory virus infections in childhood

1969

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SUMMARYNasopharyngeal secretions and cough/nasal swabs were taken from 111 children admitted to hospital in Newcastle upon Tyne with acute lower respiratory disease. A comparison was made between nasopharyngeal secretions and cough/nasal swabs as material for isolation of viruses in tissue culture. These results were, in turn, compared with those obtained by applying a fluorescent antibody technique to the exfoliated cells in the nasopharyngeal secretions for the rapid diagnosis of respiratory syncytial virus infection.More viruses were isolated in tissue culture from nasopharyngeal secretion than from cough/nasal swabs. Further evidence for the superiority of nasopharyngeal secretions was obtained by comparing the virus isolations in the laboratory in 1967 with those in 1968. Respiratory syncytial virus was not only isolated more often but more quickly in tissue culture inoculated with nasopharyngeal secretions.The fluorescent antibody technique not only provided a diagnosis on the patient's day of admission in 95% of those infected with respiratory syncytial virus but also proved to be as sensitive as the culture of nasopharyngeal secretions and considerably more sensitive than the culture of cough/nasal swabs for the diagnosis of respiratory syncytial virus infection.We wish to acknowledge the invaluable help given us by consultants, medical officers, ward sisters and their staff in the paediatric wards of the Child Health Department. We also wish to thank the technical staff in the Department of Virology for their aid.

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A comparative virological study of children in hospital with respiratory and diarrhoeal illnesses

Cited by 19 publications

References 28 publications

Stool viruses in babies in Glasgow: 1. Hospital admissions with diarrhoea

Stool viruses in babies in Glasgow: 1. Hospital admissions with diarrhoea

A year's experience of the rotavirus syndrome and its association with respiratory illness.

A comparative study of methods for the diagnosis of respiratory virus infections in childhood

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