A Comparison of Obese and Nonobese People With Asthma

Pakhalé, Smita; Doucette, Steve; Vandemheen, Katherine L.; Boulet, L; McIvor, R. Andrew; FitzGerald, J. Mark; Hernández, Paul; Lemière, Catherine; Sharma, Sat; Field, Stephen K.; Alvarez, Gonzalo G.; Dales, Robert; Aaron, Shawn D.

doi:10.1378/chest.09-2491

Cited by 79 publications

(67 citation statements)

References 27 publications

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“…In addition, information should be obtained on exacerbating triggers, and environmental or occupational factors that may be contributing. Respiratory symptoms related to obesity have also been mistaken for asthma, especially when the patient is seen in an urgent care setting [133]. Children and adults should be evaluated for other conditions that may mimic or be associated with asthma (table 6).…”

Section: Discussionmentioning

confidence: 99%

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

et al. 2013

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Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A Task Force, supported by the European Respiratory Society and American Thoracic Society, reviewed the definition and provided recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults.A literature review was performed, followed by discussion by an expert committee according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach for development of specific clinical recommendations.When the diagnosis of asthma is confirmed and comorbidities addressed, severe asthma is defined as asthma that requires treatment with high dose inhaled corticosteroids plus a second controller and/or systemic corticosteroids to prevent it from becoming “uncontrolled” or that remains “uncontrolled” despite this therapy. Severe asthma is a heterogeneous condition consisting of phenotypes such as eosinophilic asthma. Specific recommendations on the use of sputum eosinophil count and exhaled nitric oxide to guide therapy, as well as treatment with anti-IgE antibody, methotrexate, macrolide antibiotics, antifungal agents and bronchial thermoplasty are provided.Coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy.

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Section: Discussionmentioning

confidence: 99%

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

et al. 2013

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“…We collected information on covariates from clinical examinations and questionnaires in HUNT 2, age (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)30-39, 40-49 and 50-55 years), sex (female/male), family history of asthma (yes/no), current smoking status (yes/no), duration of light physical activity (,1, 1-2 or o3 h per week), years of education (,10, 10-12 or o13 years), receiving social benefits (yes/no), economic difficulties (yes/no), allergic rhinitis (yes/no) and heartburn/acid regurgitation (yes/no). Family history of asthma was defined as any family member (father, mother, brother or sister) with asthma.…”

Section: Covariablesmentioning

confidence: 99%

Metabolic syndrome and incidence of asthma in adults: the HUNT study

et al. 2013

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Obesity is a risk factor for incident asthma in adults, and obesity is a major component of metabolic syndrome. This study aimed to explore the associations of metabolic syndrome and its components with the cumulative incidence of asthma in adults.We conducted a prospective cohort study of participants who were asthma-free at baseline (n523 191) in the Nord-Trøndelag Health Study from 1995 to 2008. Baseline metabolic syndrome was categorised using the definition of the Joint Interim Statement from several international organisations. Incident asthma was self-reported at follow-up, which averaged 11 years.Metabolic syndrome was a risk factor for incident asthma (adjusted OR 1.57, 95% CI 1.31-1.87). This association was consistent in sensitivity analyses using a stricter asthma definition (adjusted OR 1.42, 95% CI 1.13-1.79). Among the components of metabolic syndrome, two remained associated with incident asthma after mutual adjustment for the other metabolic components: high waist circumference (adjusted OR 1.62, 95% CI 1.36-1.94) and elevated glucose or diabetes (adjusted OR 1.43, 95% CI 1.01-2.04).Metabolic syndrome and two of its components (high waist circumference and elevated glucose or diabetes) were associated with an increased risk of incident asthma in adults. @ERSpublications Metabolic syndrome and two of its components were associated with an increased risk of incident asthma in adults

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“…A Canadian study suggested that asthma is over diagnosed in about 30% of patients with self-reported physician-diagnosed asthma, and that this does not seem to be related to obesity [100,101].…”

Section: Obesitymentioning

confidence: 99%

“…However, obese individuals who make urgent visits for respiratory symptoms are more likely to receive a misdiagnosis of asthma [101]. Such misdiagnosis might be obscuring the true relationship between obesity and asthma.…”

Section: Obesitymentioning

confidence: 99%