A comparison of regional somatostatin and neuropeptide Y distribution in rat striatum and brain

Beal, M. Flint; Chattha, Geetinder K.; Martin, Joseph B.

doi:10.1016/0006-8993(86)90864-4

Cited by 40 publications

(10 citation statements)

References 41 publications

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“…The distribution of SOM-IR cell bodies and fibers in the guinea pig dorsal striatum is similar to that found in previous studies with rats [3,12,14,31,32], hedgehogs and sheep [17], cats, monkeys [19] and humans [21]. SOM-immunoreactive neurons and fibers are present throughout the dorsal striatum of the guinea pig.…”

Section: Discussionsupporting

confidence: 86%

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Distribution and chemical coding pattern of somatostatin immunoreactivity in the dorsal striatum of the guinea pig

Wasilewska¹,

Robak²,

Równiak³

et al. 2012

Folia Histochem Cytobiol.

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Abstract:The present study provides a detailed description of somatostatin (SOM) distribution and the colocalization pattern of SOM, neuropeptide Y (NPY) and nitric oxide synthase (NOS) in the dorsal striatum (caudate-putamen complex) of the guinea pig. Within the dorsal striatum, SOM is found in a population of medium-sized aspiny interneurons. We found that 97% of all SOM-IR neurons expressed NPY simultaneously, while 98% of all NPY-ergic perikarya was simultaneously SOM-IR. On the other hand, while 98% of all SOM-IR cells were simultaneously NOS-IR, only 91% of all NOS-containing neurons exhibited SOM-immunoreactivity. Irrespective of their chemical coding, both types of SOM-IR neurons were scattered throughout the dorsal striatum, sometimes in the form of small, loosely arranged clusters of 2-4 cells. While SOM-IR and NPY-IR nerve fibers were present in all of the studied regions, they were more numerous in the ventro-medial part of the studied structure, with the exception of its caudal portion, where SOM-IR and NPY-IR fibers additionally formed a dense network in the part corresponding to the caudate nucleus. A low expression of staining for NOS-IR fibers was seen throughout the entire dorsal striatum. In some fibers, SOM and NPY were co-expressed. Fibers expressing both SOM and NOS were not found.

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Section: Discussionsupporting

confidence: 86%

“…The morphology and chemical coding of SOM-IR neurons in the dorsal striatum has mostly been studied in rats [2,3,[12][13][14][15]. A smaller amount of data has come from cats [16], hedgehogs and sheep [17], monkeys [18,19] and humans [20,21].…”

Section: Introductionmentioning

confidence: 99%

Distribution and chemical coding pattern of somatostatin immunoreactivity in the dorsal striatum of the guinea pig

Wasilewska¹,

Robak²,

Równiak³

et al. 2012

Folia Histochem Cytobiol.

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“…NPY has been implicated in several important brain func tions such as the regulation of pituitary secretion of luteinizing hormone and growth hormone [5][6][7] and in feeding behavior [8,9]. The fact that in some neurons NPY coexists with y-aminobutyric acid [10] and catecholamines [11,12], and that NPY axo nal terminals are in close apposition to catecholaminergic [13,14] and peptidergic neurons [15][16][17] suggests that many other brain functions may be modulated by the peptide. NPY is already present in relatively high levels in the fetal brain (em bryonic days 13/14) and it reaches adult levels very rapidly in the neonate [18][19][20], Thus, it has been suggested that NPY may play an important role in the development of the perinatal brain [ 18].…”

mentioning

confidence: 99%

Regulated Production and Secretion of Immunoreactive Neuropeptide Y by Aggregating Fetal Brain Cells in Cultures

Barnea¹,

Hajibeigi²,

Cho³

et al. 1991

Neuroendocrinology

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The aim of this study was to establish a culture system of fetal brain cells that could serve as a model for the study of the developmental regulation of the neuropeptide Y(NPY) neuron. Single cell suspensions were prepared from the hypothalamic-olfactory tubercle region of 18-day-old rat fetuses, and aggregates were formed by incubation in serum-free medium under constant rotation. Aggregate formation was complete within 24–48 h, and cultures were maintained for up to 23 days. The content of immunoreactive (IR) NPY in the medium and in the aggregates increased progressively with time in culture and at each time point, the medium contained 5- to 10-fold more NPY-IR. A 48-hour exposure to forskolin resulted in a 2-fold increase in the accumulation of NPY-IR in the aggregates and in the medium, indicating that both production and secretion of NPY are regulated by the cAMP intracellular pathway. Sephadex gel filtration revealed the presence of proNPY- and NPY-size substances. The ratio of NPY- to proNPY-size substances increased progressively with age of the aggregates as well as in tissues obtained from perinatal rats of comparable age. Thus, production and secretion of NPY-IR in the cultured aggregates are regulated processes and hence, this culture system can serve as a model to study regulatory processes in the developing NPY neuron.

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“…Effects of NGF and GM1 in the Rat Neocortex Beal et al, 1986) and gamma-amino butyric acid (GABA) in the brain of many species, including rat and human (for review, see Epelbaum, 1986). Moreover, the majority of GABA neurons in the dorsomedial cortex of lizards and in the rat suprachiasmic nucleus colocalise somatostatin (Dávila et al, 1993;Buijs et al, 1995).…”

Section: Effects Of the Lesion And Ngf And/or Gm1 Therapy On Corticalmentioning

confidence: 97%

Responses of cortical noradrenergic and somatostinergic fibres and terminals to adjacent strokes and subsequent treatment with NGF and/or the ganglioside GM1

Tajrine

Garofalo

Cuello

et al. 1997

J of Neuroscience Research

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The occurrence of sprouting by fibre systems in the neocortex following lesion is still a controversial issue. In previous studies, we showed a nerve growth factor (NGF)-induced sprouting and hypertrophy of presynaptic terminals in the cholinergic fibres of the rat neocortex following stroke-type lesions, effects that were potentiated by the monosialoganglioside GM1. The present study investigated whether exogenous NGF and/or GM1 treatment could also affect the noradrenergic and somatostinergic systems in the neocortex. Immediately following unilateral vascular decortication, adult rats received, via minipump, a 7-day infusion of vehicle, NGF (12 microg/day) and/or GM1 (1.5 mg/day) into the cerebroventricular space. Thirty days postlesion, the animals were perfused with histological fixatives, the brains were removed, and relevant sections were processed for dopamine beta-hydroxylase and somatostatin immunocytochemistry at the light and electron microscopic levels. A Quantimet 920 image analysis system was used for the quantification of fibre length and size of presynaptic boutons. The lesion caused a reduction in the dopamine beta-hydroxylase-immunoreactive fibre length, which was not attenuated by either NGF or GM1 treatment or both. The somatostatin-immunoreactive network, in contrast, was unaffected by the lesion, and there was no sprouting of somatostatin fibres following trophic factor therapy. We also found no significant differences in the size and number of synapses of both the dopamine beta-hydroxylase-immunoreactive and somatostatin-immunoreactive boutons following lesion and drug treatments. These results indicate that NGF and/or GM1 therapies do not cause regrowth in the noradrenergic and somatostatinergic cortical fibre networks or their presynaptic elements following a cortical devascularizing lesion.

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A comparison of regional somatostatin and neuropeptide Y distribution in rat striatum and brain

Cited by 40 publications

References 41 publications

Distribution and chemical coding pattern of somatostatin immunoreactivity in the dorsal striatum of the guinea pig

Distribution and chemical coding pattern of somatostatin immunoreactivity in the dorsal striatum of the guinea pig

Regulated Production and Secretion of Immunoreactive Neuropeptide Y by Aggregating Fetal Brain Cells in Cultures

Responses of cortical noradrenergic and somatostinergic fibres and terminals to adjacent strokes and subsequent treatment with NGF and/or the ganglioside GM1

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