A comparison of the anti-diabetic potential of d-ribose-l-cysteine with insulin, and oral hypoglycaemic agents on pregnant rats

Osinubi, AA; Medubi, Leke Jacob; Akang, E. E. U.; Sodiq, Lawal K.; Samuel, Titilola; Kusemiju, T.O.; Osolu, James; Madu, Danladi; Fasanmade, O.A

doi:10.1016/j.toxrep.2018.08.003

Cited by 12 publications

(8 citation statements)

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“…Usually, hepatocytes supply GSH that is found in plasma and plasma GSH is kept at low concentration because of metabolism of GSH by many other cells [30]. This makes glutathione to be generally more predominant in animal cells (0.5-10 mmol/L) than in plasma (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) μmol/L) [6,30]. Furthermore, half-life of GSH in tissues varies.…”

Section: Discussionmentioning

confidence: 99%

“…DRLC was also reported to attenuate memory deficit induced by lipopolysaccharide in mice models [ 9 ]. In Sprague-Dawley rats, DRLC administration attenuated reproductive hormones and sperm parameters in aluminium-induced testicular damage [ 10 ], Streptozotocin-induced diabetic rats [ 11 ] and also as an oral hypoglycaemic agent in pregnant-diabetic rats [ 12 ]. Other studies also showed DRLC enhanced wound healing [ 13 ] and halted the progression of intervertebral disc degeneration in rabbits [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Changes in antioxidants status, atherogenic index and cardiovascular variables after prolonged doses of D-ribose-L-cysteine in male Wistar rats

Ojetola

Adedeji

Fasanmade

2021

Heliyon

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D-ribose-L-cysteine (DRLC) acts as a rate limiting substrate for the synthesis of glutathione (GSH). GSH deficiency has been linked to oxidative stress, hypertension and cardiovascular diseases. There are limited findings on the effects of DRLC in the physiologic state. This study was therefore designed to investigate cardiovascular effects of different doses of DRLC in normal Wistar rats. Fifteen male Wistar rats were assigned into 3 groups (n ¼ 5). Group 1 was administered orally with 10 mg/kg distilled water (Control). Groups 2 and 3 were administered orally with DRLC 125 mg/kg and 250 mg/kg respectively daily for 8 weeks, respectively. Animals were weighed; blood pressure and heart rate measured using rat tail cuff method. They were euthanized, blood collected and organs harvested. Serum C-reactive protein (CRP) was determined through ELISA. Gamma glutamyl transferase (GGT), heart GSH, glutathione peroxidase (GPx), total thiol and lipid profile and were assessed through spectrophotometry. Data were expressed as mean AE SEM and compared by ANOVA at P < 0.05. DRLC 250 significantly increased total thiol, GSH and GPx in heart tissues but decreased GGT, atherogenic index and CRP in normal male Wistar rats compared to DRLC 125 and control. DRLC supplementation in normal male Wistar rats may sustain cardio functions and decrease atherogenicity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in antioxidants status, atherogenic index and cardiovascular variables after prolonged doses of D-ribose-L-cysteine in male Wistar rats

Ojetola

Adedeji

Fasanmade

2021

Heliyon

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“…Tetrapleura tetraptera treatment shows no significant impact on crown-rump length, foetal and ovarian weight. This is adduced to nutritional bioactive component of the TT on placental barrier to effectively regulate exogenous maternal change ( Blundell et al., 2016 ; Abraham et al., 2018 ). We can therefore, deduce that bioactive constituent of TT is effective and safe in management of pregnancy from first trimester to parturition period which is evidence in weight of placental and empty uterus.…”

Section: Discussionmentioning

confidence: 99%

“…These mating animals were left together overnight. Vaginal lavage was taken on the morning (estrous day of the cycle) following pairing between 8:00–9:00 am The presence of sperm spermatozoa in the lavage was marked as day 1 of pregnancy ( Abraham et al., 2018 ).…”

Section: Methodsmentioning

confidence: 99%

Aqueous extract of Tetrapleura tetraptera fruit peels influence copulatory behavior and maintain testicular integrity in sexually mature male Sprague-Dawley rats: Pro-fertility evaluation and histomorphometry evidence

Adelakun

Ogunlade

Olawuyi

et al. 2021

Current Research in Physiology

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Tetrapleura tetraptera (TT) has been used as a spice, dietary supplement and medicine for various ailments. This study evaluate influence of Tetrapleura tetraptera extract on testis and copulatory behavior in sexually mature male rats. Thirty-two male and sixty-four virgin female rats weighing 150–200 g were used for this study. Male rats randomly divided into four groups of eight (n = 8) rats each. Group A: Control given 2 ml distilled water, group B, C and D received 50, 300 and 700 mg/kg bwt TT for 56 days through oral gavage. The female rats were used for fertility test. Testicular histology, histomorphology, copulatory behavior, sperm parameters, testosterone (TET), luteinizing hormone (LH), follicle stimulating hormone (FSH), glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA) and fertility test were investigated. Tetrapleura tetraptera significantly increase sperm count, motility, normal morphology, daily sperm production, efficiency of sperm production, sperm (average path velocity, straight line velocity and curvilinear velocity), TET, LH, FHS, SOD, GPx, CAT, number of pregnant females, number of fetuses, seminiferous diameter, epithelium thickness and decrease abnormal morphology, seminiferous height, tubule lumen and MDA across the group as compared with control group. Improved testicular histological integrity, sexual behaviour and libido by increased frequencies of mount, intromission, ejaculation and ejaculatory latency. Latencies of mount, intromission and post-ejaculation were significantly reduced. Also, observed increase spermatocytes and spermatids showed no significant difference in spermatogonia cell counts. Tetrapleura tetraptera therefore, enhance steroidogenesis, spermatogenesis, and improved testicular histological integrity and boost sexual competence in male rats.

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“…The rats were divided into four groups (n = 8), labeled groups A, B, C, and D. The Arsenic (Mehranjani & Hemadi, 2007) and DRLC dosages (Osinubi et al, 2018) were prepared daily. Group A received normal saline as placebo; Group B was administered with 8mg/kg BW arsenic only; Group C was administered with 8 mg/kg BW arsenic followed by 10 mg/kg BW DRLC (low dose) and Group D were administered with 8mg/kg BW arsenic followed by 30 mg/kg BW DRLC (high dose).…”

Section: Experimental Protocolmentioning

confidence: 99%

Potentiating response of D- Ribose-L-Cysteine on Sodium arsenate- induced hormonal imbalance, spermatogenesis impairments and histomorphometric alterations in adult male Wistar rat

Ogunlade

Adelakun

Ukwenya

et al. 2021

JBRA

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Objective: Reproductive toxicity is an important health challenge, mostly associated with exposure to several environmental toxicants. Arsenic is a ubiquitous toxic compound naturally present in the environment. This study was carried out to evaluate the dietary supplements of D-Ribose-L-Cysteine against sodium arsenate-induced testicular toxicity in adult male Wistar rats.Methods: A total of 32 male rats (150-250g) were randomly divided into four ( 4) groups (n=8). Group A received normal saline as placebo; Group B received 8mg/ kg BW of Sodium arsenate only; Group C received 8mg/ kg BW of Sodium arsenate and 10 mg/kg BW of D-Ribose-L-cysteine; Group D received 8mg/kg BW of Sodium arsenate and 30 mg/kg BW of D-Ribose-L-cysteine. All administration was done via oral gavage for 28 days, thereafter the animals were sedated with pentobarbital sodium (intraperitoneally); we obtained testes and blood serum for analysis.Results: The results showed abnormal testicular morphology with degeneration and decrease in spermatogonia, vacuolation and empty lumen, intense necrosis, spermatogenesis disruption (decrease sperm count, motility, viability) and degraded germinal epithelium of the seminiferous tubules, reduction in the hormone profile (FSH, LH, and TT) and oxidative stress parameters (CAT, GSH, and SOD) with a corresponding increase in MDA level in the arsenic-only treated rats (group B) compared to their control counterparts (group A), but it was ameliorated after DRLC administration, both in low and high doses, respectively.Conclusions: D-Ribose-L-Cysteine attenuated distorted testicular morphology, altered semen characteristics, hormone profile, and oxidative stress markers by preventing the deleterious toxicity of sodium arsenate.

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A comparison of the anti-diabetic potential of d-ribose-l-cysteine with insulin, and oral hypoglycaemic agents on pregnant rats

Abstract: Graphical abstract

Cited by 12 publications

References 60 publications

Changes in antioxidants status, atherogenic index and cardiovascular variables after prolonged doses of D-ribose-L-cysteine in male Wistar rats

Changes in antioxidants status, atherogenic index and cardiovascular variables after prolonged doses of D-ribose-L-cysteine in male Wistar rats

Aqueous extract of Tetrapleura tetraptera fruit peels influence copulatory behavior and maintain testicular integrity in sexually mature male Sprague-Dawley rats: Pro-fertility evaluation and histomorphometry evidence

Potentiating response of D- Ribose-L-Cysteine on Sodium arsenate- induced hormonal imbalance, spermatogenesis impairments and histomorphometric alterations in adult male Wistar rat

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